7WJV
Crystal structure of human liver FBPase complexed with an covalent inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Fructose-1,6-bisphosphatase 1 | polymer | 348 | 38206.8 | 4 | UniProt (Q2TU34) Pfam (PF00316) Pfam (PF18913) UniProt (by SIFTS) (P09467) | Homo sapiens (human) | Growth-inhibiting protein 17,cDNA FLJ75786,highly similar to Homo sapiens fructose-1,6-bisphosphatase 1 (FBP1),mRNA |
| 2 | E, I, L, N (A, B, C, D) | ADENOSINE MONOPHOSPHATE | non-polymer | 347.2 | 4 | Chemie (AMP) PubChem (224) PubChem (34768) PubChem (83862) PubChem (446048) PubChem (515384) PubChem (638042) PubChem (5316444) PubChem (5742864) PubChem (12163610) PubChem (12358355) PubChem (16397049) PubChem (16760266) PubChem (40467049) PubChem (40469468) PubChem (44348067) PubChem (45358029) PubChem (46874558) PubChem (40459109) PubChem (46875232) PubChem (177678969) PubChem (6083) PubChem (1549371) PubChem (92144436) PubChem (57358045) PubChem (57879893) PubChem (57879902) PubChem (12358354) PubChem (122197642) PubChem (162290139) PubChem (162946266) PubChem (171699505) | |||
| 3 | F (A) | 1,2-BENZISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDE | non-polymer | 183.2 | 1 | Chemie (LSA) PubChem (5143) | |||
| 4 | G, K (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) PubChem (888) | |||
| 5 | H (B) | benzylcarbamic acid | non-polymer | 151.2 | 1 | Chemie (PMQ) PubChem (230054) | |||
| 6 | J, M, O (B, C, D) | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) PubChem (753) | |||
| 7 | P, Q, R, S (A, B, C, D) | water | water | 18.0 | 1158 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 0 - 337 (UniProt: Q2TU34)
| PDB | External Database | Details |
|---|---|---|
| Leu 338 | - | expression tag |
| Glu 339 | - | expression tag |
| His 340 | - | expression tag |
| His 341 | - | expression tag |
| His 342 | - | expression tag |
| His 343 | - | expression tag |
| His 344 | - | expression tag |
| His 345 | - | expression tag |
| His 346 | - | expression tag |
| His 347 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 152827.4 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 2048.1 | |
| All* | Total formula weight | 154875.5 |
