7WJV
Crystal structure of human liver FBPase complexed with an covalent inhibitor
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | Fructose-1,6-bisphosphatase 1 | polymer | 348 | 38206.8 | 4 | UniProt (Q2TU34) Pfam (PF00316) Pfam (PF18913) UniProt (by SIFTS) (P09467) In PDB | Homo sapiens (human) | Growth-inhibiting protein 17,cDNA FLJ75786,highly similar to Homo sapiens fructose-1,6-bisphosphatase 1 (FBP1),mRNA |
2 | A, B, C, D | ADENOSINE MONOPHOSPHATE | non-polymer | 347.2 | 4 | Chemie (AMP) | |||
3 | A | 1,2-BENZISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDE | non-polymer | 183.2 | 1 | Chemie (LSA) | |||
4 | A, B | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
5 | B | benzylcarbamic acid | non-polymer | 151.2 | 1 | Chemie (PMQ) | |||
6 | B, C, D | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
7 | water | water | 18.0 | 1158 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 0 - 337 (UniProt: Q2TU34)
PDB | External Database | Details |
---|---|---|
Leu 338 | - | expression tag |
Glu 339 | - | expression tag |
His 340 | - | expression tag |
His 341 | - | expression tag |
His 342 | - | expression tag |
His 343 | - | expression tag |
His 344 | - | expression tag |
His 345 | - | expression tag |
His 346 | - | expression tag |
His 347 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 152827.4 | |
Non-Polymers* | Number of molecules | 11 |
Total formula weight | 2048.1 | |
All* | Total formula weight | 154875.5 |