7WJV

Crystal structure of human liver FBPase complexed with an covalent inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Fructose-1,6-bisphosphatase 1	polymer	348	38206.8	4	UniProt (Q2TU34) Pfam (PF00316) Pfam (PF18913) UniProt (by SIFTS) (P09467)	Homo sapiens (human)	Growth-inhibiting protein 17,cDNA FLJ75786,highly similar to Homo sapiens fructose-1,6-bisphosphatase 1 (FBP1),mRNA
2	E, I, L, N (A, B, C, D)	ADENOSINE MONOPHOSPHATE	non-polymer		347.2	4	Chemie (AMP)
3	F (A)	1,2-BENZISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDE	non-polymer		183.2	1	Chemie (LSA)
4	G, K (A, B)	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
5	H (B)	benzylcarbamic acid	non-polymer		151.2	1	Chemie (PMQ)
6	J, M, O (B, C, D)	GLYCEROL	non-polymer		92.1	3	Chemie (GOL)
7	P, Q, R, S (A, B, C, D)	water	water		18.0	1158	Chemie (HOH)

Sequence modifications

A, B, C, D: 0 - 337 (UniProt: Q2TU34)

PDB	External Database	Details
Leu 338	-	expression tag
Glu 339	-	expression tag
His 340	-	expression tag
His 341	-	expression tag
His 342	-	expression tag
His 343	-	expression tag
His 344	-	expression tag
His 345	-	expression tag
His 346	-	expression tag
His 347	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	152827.4
Non-Polymers*	Number of molecules	11
	Total formula weight	2048.1
All*	Total formula weight	154875.5

*Water molecules are not included.