PDB: 1328 件ウェブページステータス検索Chemie searchBIRD

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3L8Z	H-Ras wildtype new crystal form 分子名称: CALCIUM ION, GTPase HRas, MAGNESIUM ION, ... 著者 Rosnizeck, I.C, Graf, T, Spoerner, M, Traenkle, J, Filchtinski, D, Herrmann, C, Gremer, L, Vetter, I.R, Wittinghofer, A, Koenig, B, Kalbitzer, H.R. 登録日 2010-01-04 公開日 2011-01-05 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.44 Å) 主引用文献 Stabilizing a weak binding state for effectors in the human ras protein by cyclen complexes Angew.Chem.Int.Ed.Engl., 49, 2010
3LAW	Structure of GTP-bound L129F mutant Rab7 分子名称: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Ras-related protein Rab-7a 著者 McCray, B.A, Skordalakes, E, Taylor, J.P. 登録日 2010-01-07 公開日 2010-01-26 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Disease mutations in Rab7 result in unregulated nucleotide exchange and inappropriate activation. Hum.Mol.Genet., 19, 2010
3LBN	Ras soaked in Magnesium Acetate 分子名称: CALCIUM ION, GTPase HRas, MAGNESIUM ION, ... 著者 Holzapfel, G, Buhrman, G, Mattos, C. 登録日 2010-01-08 公開日 2010-03-02 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.862 Å) 主引用文献 Allosteric modulation of Ras positions Q61 for a direct role in catalysis. Proc.Natl.Acad.Sci.USA, 107, 2010
3LBI	Ras soaked in Magnesium Acetate and back soaked in Calcium Acetate 分子名称: ACETATE ION, CALCIUM ION, GTPase HRas, ... 著者 Holzapfel, G, Buhrman, G, Mattos, C. 登録日 2010-01-08 公開日 2010-03-02 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.087 Å) 主引用文献 Allosteric modulation of Ras positions Q61 for a direct role in catalysis. Proc.Natl.Acad.Sci.USA, 107, 2010
3LO5	Crystal Structure of the dominant negative S17N mutant of Ras 分子名称: CALCIUM ION, GTPase HRas, GUANOSINE-5'-DIPHOSPHATE, ... 著者 Nassar, N, Singh, K, Garcia-Diaz, M. 登録日 2010-02-03 公開日 2010-03-02 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.568 Å) 主引用文献 Structure of the Dominant Negative S17N Mutant of Ras Biochemistry, 49, 2010
3LBH	Ras soaked in Calcium Acetate 分子名称: ACETATE ION, CALCIUM ION, GTPase HRas, ... 著者 Holzapfel, G, Buhrman, G, Mattos, C. 登録日 2010-01-08 公開日 2010-03-02 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Allosteric modulation of Ras positions Q61 for a direct role in catalysis. Proc.Natl.Acad.Sci.USA, 107, 2010
3MJH	Crystal Structure of Human Rab5A in complex with the C2H2 Zinc Finger of EEA1 分子名称: Early endosome antigen 1, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... 著者 Mishra, A.K, Eathiraj, S, Lambright, D.G. 登録日 2010-04-12 公開日 2010-05-05 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.03 Å) 主引用文献 Structural basis for Rab GTPase recognition and endosome tethering by the C2H2 zinc finger of Early Endosomal Autoantigen 1 (EEA1). Proc.Natl.Acad.Sci.USA, 107, 2010
3OES	Crystal structure of the small GTPase RhebL1 分子名称: GTPase RhebL1, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER 著者 Nedyalkova, L, Zhong, N, Tempel, W, Tong, Y, Shen, L, Loppnau, P, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC) 登録日 2010-08-13 公開日 2010-08-25 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.301 Å) 主引用文献 Crystal structure of the small GTPase RhebL1 to be published
3NKV	Crystal structure of Rab1b covalently modified with AMP at Y77 分子名称: ADENOSINE MONOPHOSPHATE, BARIUM ION, MAGNESIUM ION, ... 著者 Mueller, M.P, Peters, H, Blankenfeldt, W, Goody, R.S, Itzen, A. 登録日 2010-06-21 公開日 2010-08-04 最終更新日 2017-08-23 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 The Legionella effector protein DrrA AMPylates the membrane traffic regulator Rab1b. Science, 329, 2010
3OIU	H-RasQ61L with allosteric switch in the "on" state 分子名称: ACETATE ION, CALCIUM ION, GTPase HRas, ... 著者 Buhrman, G, Mattos, C. 登録日 2010-08-20 公開日 2010-12-08 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.32 Å) 主引用文献 Allosteric Modulation of Ras-GTP Is Linked to Signal Transduction through RAF Kinase. J.Biol.Chem., 286, 2011
3OIW	H-RasG12V with allosteric switch in the "on" state 分子名称: ACETATE ION, CALCIUM ION, GTPase HRas, ... 著者 Kumar, S, Buhrman, G, Mattos, C. 登録日 2010-08-20 公開日 2010-12-08 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 Allosteric Modulation of Ras-GTP Is Linked to Signal Transduction through RAF Kinase. J.Biol.Chem., 286, 2011
3OIV	H-RasG12V with allosteric switch in the "off" state 分子名称: 2,3-DIHYDROXY-1,4-DITHIOBUTANE, CALCIUM ION, GTPase HRas, ... 著者 Buhrman, G, Mattos, C. 登録日 2010-08-20 公開日 2010-12-08 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.837 Å) 主引用文献 Allosteric Modulation of Ras-GTP Is Linked to Signal Transduction through RAF Kinase. J.Biol.Chem., 286, 2011
4OBE	Crystal Structure of GDP-bound Human KRas 分子名称: GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION 著者 Hunter, J.C, Gurbani, D, Chen, Z, Westover, K.D. 登録日 2014-01-07 公開日 2014-06-04 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.24 Å) 主引用文献 In situ selectivity profiling and crystal structure of SML-8-73-1, an active site inhibitor of oncogenic K-Ras G12C. Proc.Natl.Acad.Sci.USA, 111, 2014
4OJK	Structure of the cGMP Dependent Protein Kinase II and Rab11b Complex 分子名称: GUANOSINE-5'-DIPHOSPHATE, Ras-related protein Rab-11B, cGMP-dependent protein kinase 2 著者 Reger, A.S, Yang, M.P, Guo, E, Kim, C. 登録日 2014-01-21 公開日 2014-08-06 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.657 Å) 主引用文献 Crystal Structure of the cGMP-dependent Protein Kinase II Leucine Zipper and Rab11b Protein Complex Reveals Molecular Details of G-kinase-specific Interactions. J.Biol.Chem., 289, 2014
4Q03	Second-site screening of K-Ras in the presence of covalently attached first-site ligands 分子名称: 4-bromobenzenethiol, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ... 著者 Sun, Q, Phan, J, Friberg, A, Camper, D.V, Olejniczak, E.T, Fesik, S.W. 登録日 2014-03-31 公開日 2014-09-10 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.201 Å) 主引用文献 A method for the second-site screening of K-Ras in the presence of a covalently attached first-site ligand. J.Biomol.Nmr, 60, 2014
4PZY	Second-site screening of K-Ras in the presence of covalently attached first-site ligands 分子名称: 2-chloro-1-(1H-indol-3-yl)ethanone, GUANOSINE-5'-DIPHOSPHATE, K-Ras, ... 著者 Sun, Q, Phan, J, Friberg, A, Camper, D.V, Olejniczak, E.T, Fesik, S.W. 登録日 2014-03-31 公開日 2014-09-10 実験手法 X-RAY DIFFRACTION (1.88 Å) 主引用文献 A method for the second-site screening of K-Ras in the presence of a covalently attached first-site ligand. J.Biomol.Nmr, 60, 2014
4Q01	Second-site screening of K-Ras in the presence of covalently attached first-site ligands 分子名称: GUANOSINE-5'-DIPHOSPHATE, K-Ras, MAGNESIUM ION, ... 著者 Sun, Q, Phan, J, Friberg, A, Camper, D.V, Olejniczak, E.T, Fesik, S.W. 登録日 2014-03-31 公開日 2014-09-10 実験手法 X-RAY DIFFRACTION (1.291 Å) 主引用文献 A method for the second-site screening of K-Ras in the presence of a covalently attached first-site ligand. J.Biomol.Nmr, 60, 2014
4PZZ	Second-site screening of K-Ras in the presence of covalently attached first-site ligands 分子名称: 1H-benzimidazol-2-ylmethanethiol, GUANOSINE-5'-DIPHOSPHATE, K-Ras, ... 著者 Sun, Q, Phan, J, Friberg, A, Camper, D.V, Olejniczak, E.T, Fesik, S.W. 登録日 2014-03-31 公開日 2014-09-10 実験手法 X-RAY DIFFRACTION (1.403 Å) 主引用文献 A method for the second-site screening of K-Ras in the presence of a covalently attached first-site ligand. J.Biomol.Nmr, 60, 2014
4O2R	Structure of Mus musculus Rheb G63V mutant bound to GDP 分子名称: GTP-binding protein Rheb, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION 著者 Mazhab-Jafari, M.T, Marshall, C.B, Ho, J, Ishiyama, N, Stambolic, V, Ikura, M. 登録日 2013-12-17 公開日 2014-03-26 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Structure-guided mutation of the conserved G3-box glycine in Rheb generates a constitutively activated regulator of mammalian target of rapamycin (mTOR). J.Biol.Chem., 289, 2014
4O25	Structure of Wild Type Mus musculus Rheb bound to GTP 分子名称: GTP-binding protein Rheb, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION 著者 Mazhab-Jafari, M.T, Marshall, C.B, Ho, J, Ishiyama, N, Stambolic, V, Ikura, M. 登録日 2013-12-16 公開日 2014-03-26 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structure-guided mutation of the conserved G3-box glycine in Rheb generates a constitutively activated regulator of mammalian target of rapamycin (mTOR). J.Biol.Chem., 289, 2014
4O2L	Structure of Mus musculus Rheb G63A mutant bound to GTP 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ACETATE ION, GTP-binding protein Rheb, ... 著者 Mazhab-Jafari, M.T, Marshall, C.B, Ho, J, Ishiyama, N, Stambolic, V, Ikura, M. 登録日 2013-12-17 公開日 2014-03-26 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structure-guided mutation of the conserved G3-box glycine in Rheb generates a constitutively activated regulator of mammalian target of rapamycin (mTOR). J.Biol.Chem., 289, 2014
4NMM	Crystal Structure of a G12C Oncogenic Variant of Human KRas Bound to a Novel GDP Competitive Covalent Inhibitor 分子名称: 5'-O-[(S)-{[(S)-[2-(acetylamino)ethoxy](hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]guanosine, GTPase KRas, MAGNESIUM ION 著者 Hunter, J.C, Gurbani, D, Lim, S.M, Westover, K.D. 登録日 2013-11-15 公開日 2014-06-04 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.89 Å) 主引用文献 In situ selectivity profiling and crystal structure of SML-8-73-1, an active site inhibitor of oncogenic K-Ras G12C. Proc.Natl.Acad.Sci.USA, 111, 2014
4PHG	Crystal structure of Ypt7 covalently modified with GTP 分子名称: GTP-binding protein YPT7, MAGNESIUM ION, N-[3-(propanoylamino)propyl]guanosine 5'-(tetrahydrogen triphosphate), ... 著者 Koch, D, Wiegandt, D, Vieweg, S, Hofmann, F, Wu, Y, Itzen, A, Mueller, M.P, Goody, R.S. 登録日 2014-05-06 公開日 2014-05-28 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Locking GTPases covalently in their functional states. Nat Commun, 6, 2015
4PHH	Crystal structure of Ypt7 covalently modified with GNP 分子名称: 5'-O-[(R)-hydroxy{[(S)-hydroxy(phosphonoamino)phosphoryl]oxy}phosphoryl]-N-[3-(propanoylamino)propyl]guanosine, CHLORIDE ION, GTP-binding protein YPT7, ... 著者 Wiegandt, D, Vieweg, S, Hofmann, F, Koch, D, Wu, Y, Itzen, A, Mueller, M.P, Goody, R.S. 登録日 2014-05-06 公開日 2014-05-28 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Locking GTPases covalently in their functional states. Nat Commun, 6, 2015
4PHF	Crystal structure of Ypt7 covalently modified with GDP 分子名称: GTP-binding protein YPT7, MAGNESIUM ION, N-[3-(propanoylamino)propyl]guanosine 5'-(trihydrogen diphosphate), ... 著者 Vieweg, S, Wiegandt, D, Hofmann, F, Koch, D, Wu, Y, Itzen, A, Mueller, M.P, Goody, R.S. 登録日 2014-05-06 公開日 2014-05-28 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Locking GTPases covalently in their functional states. Nat Commun, 6, 2015

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