PDB: 1359 件ウェブページステータス検索Chemie searchBIRD

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7ACF	CRYSTAL STRUCTURE OF CRYSTAL FORM 2 OF AN ACTIVE KRAS G12D (GPPCP) DIMER IN COMPLEX WITH BI-5747 分子名称: (3~{S})-5-oxidanyl-3-[2-[[6-[[3-[(1~{S})-6-oxidanyl-3-oxidanylidene-1,2-dihydroisoindol-1-yl]-1~{H}-indol-2-yl]methylamino]hexylamino]methyl]-1~{H}-indol-3-yl]-2,3-dihydroisoindol-1-one, GTPase KRas, MAGNESIUM ION, ... 著者 Kessler, D. 登録日 2020-09-10 公開日 2020-11-18 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.91 Å) 主引用文献 Reply to Tran et al.: Dimeric KRAS protein-protein interaction stabilizers. Proc. Natl. Acad. Sci. U.S.A., 117, 2020
6MBQ	Crystal structure of Mg-free wild-type KRAS (2-166) bound to GMPPNP in the state 1 conformation 分子名称: 1,2-ETHANEDIOL, GTPase KRas, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... 著者 Dharmaiah, S, Davies, D.R, Abendroth, J, Gillette, W.G, Stephen, A.G, Simanshu, D.K. 登録日 2018-08-30 公開日 2019-07-31 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.35 Å) 主引用文献 Structures of N-terminally processed KRAS provide insight into the role of N-acetylation. Sci Rep, 9, 2019
6M9W	Structure of Mg-free KRAS4b (2-169) bound to GDP with the switch-I in fully open conformation 分子名称: GTPase KRas, GUANOSINE-5'-DIPHOSPHATE 著者 Dharmaiah, S, Tran, T.H, Yan, W, Simanshu, D.K. 登録日 2018-08-24 公開日 2019-07-31 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Structures of N-terminally processed KRAS provide insight into the role of N-acetylation. Sci Rep, 9, 2019
1GNQ	X-RAY CRYSTAL STRUCTURE ANALYSIS OF THE CATALYTIC DOMAIN OF THE ONCOGENE PRODUCT P21H-RAS COMPLEXED WITH CAGED GTP AND MANT DGPPNHP 分子名称: C-H-RAS P21 PROTEIN, GUANOSINE 5'-TRIPHOSPHATE P3-[1-(2-NITROPHENYL)ETHYL ESTER], MAGNESIUM ION 著者 Scheidig, A, Franken, S.M, Corrie, J.E.T, Reid, G.P, Wittinghofer, A, Pai, E.F, Goody, R.S. 登録日 1995-05-11 公開日 1995-07-31 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 X-ray crystal structure analysis of the catalytic domain of the oncogene product p21H-ras complexed with caged GTP and mant dGppNHp. J.Mol.Biol., 253, 1995
721P	THREE-DIMENSIONAL STRUCTURES OF H-RAS P21 MUTANTS: MOLECULAR BASIS FOR THEIR INABILITY TO FUNCTION AS SIGNAL SWITCH MOLECULES 分子名称: H-RAS P21 PROTEIN, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER 著者 Krengel, U, Scherer, A, Kabsch, W, Wittinghofer, A, Pai, E.F. 登録日 1991-06-06 公開日 1994-01-31 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Three-dimensional structures of H-ras p21 mutants: molecular basis for their inability to function as signal switch molecules. Cell(Cambridge,Mass.), 62, 1990
1Q21	CRYSTAL STRUCTURES AT 2.2 ANGSTROMS RESOLUTION OF THE CATALYTIC DOMAINS OF NORMAL RAS PROTEIN AND AN ONCOGENIC MUTANT COMPLEXED WITH GSP 分子名称: C-H-RAS P21 PROTEIN CATALYTIC DOMAIN, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION 著者 Kim, S.-H. 登録日 1991-09-25 公開日 1992-07-15 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Crystal structures at 2.2 A resolution of the catalytic domains of normal ras protein and an oncogenic mutant complexed with GDP. J.Mol.Biol., 217, 1991
6MBU	Crystal structure of wild-type KRAS (1-169) bound to GDP and Mg (Space group P3) 分子名称: GLYCEROL, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ... 著者 Dharmaiah, S, Tran, T.H, Yan, W, Simanshu, D.K. 登録日 2018-08-30 公開日 2019-07-31 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Structures of N-terminally processed KRAS provide insight into the role of N-acetylation. Sci Rep, 9, 2019
1HUQ	1.8A CRYSTAL STRUCTURE OF THE MONOMERIC GTPASE RAB5C (MOUSE) 分子名称: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, RAB5C 著者 Merithew, E, Hatherly, S, Dumas, J.J, Lawe, D.C, Heller-Harrison, R, Lambright, D.G. 登録日 2001-01-04 公開日 2001-02-07 最終更新日 2023-08-09 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structural plasticity of an invariant hydrophobic triad in the switch regions of Rab GTPases is a determinant of effector recognition. J.Biol.Chem., 276, 2001
7ACQ	CRYSTAL STRUCTURE OF INACTIVE KRAS G12D (GDP) IN COMPLEX WITH THE SOAKED DIMERIC INHIBITOR BI-5747 分子名称: (3~{S})-5-oxidanyl-3-[2-[[6-[[3-[(1~{S})-6-oxidanyl-3-oxidanylidene-1,2-dihydroisoindol-1-yl]-1~{H}-indol-2-yl]methylamino]hexylamino]methyl]-1~{H}-indol-3-yl]-2,3-dihydroisoindol-1-one, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ... 著者 Kessler, D. 登録日 2020-09-11 公開日 2020-11-18 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.86 Å) 主引用文献 CRYSTAL STRUCTURE OF INACTIVE KRAS G12D (GDP) IN COMPLEX WITH THE SOAKED DIMERIC INHIBITOR BI00925747 To Be Published
6MTA	KRAS P34R mutant structure in complex with GTP analogue 分子名称: GTPase KRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER 著者 Bera, A.K, Westover, K.D. 登録日 2018-10-19 公開日 2020-04-15 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 GTP hydrolysis is modulated by Arg34 in the RASopathy-associated KRASP34R. Birth Defects Res, 112, 2020
7BTA	Crystal structure of Rheb D60K mutant bound to GDP 分子名称: GTP-binding protein Rheb, GUANOSINE-5'-DIPHOSPHATE, PHOSPHATE ION 著者 Zhang, C, Zhang, T, Ding, J. 登録日 2020-03-31 公開日 2020-06-17 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Molecular basis for the functions of dominantly active Y35N and inactive D60K Rheb mutants in mTORC1 signaling. J Mol Cell Biol, 12, 2020
7BTC	Crystal structure of Rheb Y35N mutant bound to GDP 分子名称: GTP-binding protein Rheb, GUANOSINE-5'-DIPHOSPHATE 著者 Zhang, C, Zhang, T, Ding, J. 登録日 2020-04-01 公開日 2020-06-17 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.101 Å) 主引用文献 Molecular basis for the functions of dominantly active Y35N and inactive D60K Rheb mutants in mTORC1 signaling. J Mol Cell Biol, 12, 2020
7BTD	Crystal structure of Rheb Y35N mutant bound to GppNHp 分子名称: GTP-binding protein Rheb, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER 著者 Zhang, C, Zhang, T, Ding, J. 登録日 2020-04-01 公開日 2020-06-17 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Molecular basis for the functions of dominantly active Y35N and inactive D60K Rheb mutants in mTORC1 signaling. J Mol Cell Biol, 12, 2020
1G17	CRYSTAL STRUCTURE OF SEC4-GUANOSINE-5'-(BETA,GAMMA)-IMIDOTRIPHOSPHATE 分子名称: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, RAS-RELATED PROTEIN SEC4 著者 Stroupe, C, Brunger, A.T. 登録日 2000-10-10 公開日 2000-12-11 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal structures of a Rab protein in its inactive and active conformations. J.Mol.Biol., 304, 2000
2LCF	Solution structure of GppNHp-bound H-RasT35S mutant protein 分子名称: GTPase HRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER 著者 Araki, M, Shima, F, Yoshikawa, Y, Muraoka, S, Ijiri, Y, Nagahara, Y, Shirono, T, Kataoka, T, Tamura, A. 登録日 2011-04-28 公開日 2011-09-28 最終更新日 2024-05-01 実験手法 SOLUTION NMR 主引用文献 Solution structure of the state 1 conformer of GTP-bound H-Ras protein and distinct dynamic properties between the state 1 and state 2 conformers. J.Biol.Chem., 286, 2011
1RYF	Alternative Splicing of Rac1 Generates Rac1b, a Self-activating GTPase 分子名称: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ras-related C3 botulinum toxin substrate 1 isoform Rac1b 著者 Ahmadian, M.R, Fiegen, D. 登録日 2003-12-22 公開日 2004-01-27 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Alternative Splicing of Rac1 Generates Rac1b, a Self-activating GTPase J.Biol.Chem., 279, 2004
2N42	EC-NMR Structure of Human H-RasT35S mutant protein Determined by Combining Evolutionary Couplings (EC) and Sparse NMR Data 分子名称: GTPase HRas 著者 Tang, Y, Huang, Y.J, Hopf, T.A, Sander, C, Marks, D, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) 登録日 2015-06-16 公開日 2015-07-01 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Protein structure determination by combining sparse NMR data with evolutionary couplings. Nat.Methods, 12, 2015
6MQT	HRAS G12S in complex with GDP 分子名称: GTPase HRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION 著者 Bera, A.K, Westover, K.D. 登録日 2018-10-10 公開日 2020-04-15 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.498 Å) 主引用文献 HRAS G12S in complex with GDP To Be Published
6MNX	Structural basis of impaired hydrolysis in KRAS Q61H mutant 分子名称: GTPase KRas, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION 著者 Bera, A.K, Westover, K.D. 登録日 2018-10-03 公開日 2020-04-15 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 KRASQ61HPreferentially Signals through MAPK in a RAF Dimer-Dependent Manner in Non-Small Cell Lung Cancer. Cancer Res., 80, 2020
2L0X	Solution structure of the 21 kDa GTPase RHEB bound to GDP 分子名称: GTP-binding protein Rheb, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION 著者 Stoll, R, Heumann, R, Berghaus, C, Kock, G. 登録日 2010-07-19 公開日 2010-08-04 最終更新日 2024-05-01 実験手法 SOLUTION NMR 主引用文献 Ras homolog enriched in brain (Rheb) enhances apoptotic signaling. J.Biol.Chem., 285, 2010
6MQN	Crystal structure of KRAS V14I-GDP demonstrating disorder switch 1 conformation - Form 2 分子名称: GTPase KRas, GUANOSINE-5'-DIPHOSPHATE 著者 Bera, A.K, Westover, K.D. 登録日 2018-10-10 公開日 2019-07-31 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Structural basis of the atypical activation mechanism of KRASV14I. J.Biol.Chem., 294, 2019
6N2K	Tetrahydropyridopyrimidines as Covalent Inhibitors of KRAS-G12C 分子名称: 1-{4-[2-{[(2R)-1-(dimethylamino)propan-2-yl]oxy}-7-(3-hydroxynaphthalen-1-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl]piperazin-1-yl}propan-1-one, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ... 著者 Vigers, G.P. 登録日 2018-11-13 公開日 2018-12-12 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.72 Å) 主引用文献 Discovery of Tetrahydropyridopyrimidines as Irreversible Covalent Inhibitors of KRAS-G12C with In Vivo Activity. ACS Med Chem Lett, 9, 2018
1RYH	Alternative Splicing of Rac1 Generates Rac1b, a Self-activating GTPase 分子名称: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ras-related C3 botulinum toxin substrate 1 isoform Rac1b 著者 Ahmadian, M.R, Fiegen, D. 登録日 2003-12-22 公開日 2004-01-27 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Alternative Splicing of Rac1 Generates Rac1b, a Self-activating GTPase J.Biol.Chem., 279, 2004
6MS9	GDP-bound KRAS P34R mutant 分子名称: GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION 著者 Bera, A.K, Westover, K.D. 登録日 2018-10-16 公開日 2020-04-15 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.49 Å) 主引用文献 GTP hydrolysis is modulated by Arg34 in the RASopathy-associated KRASP34R. Birth Defects Res, 112, 2020
1FTN	CRYSTAL STRUCTURE OF THE HUMAN RHOA/GDP COMPLEX 分子名称: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, TRANSFORMING PROTEIN RHOA (H12) 著者 Wei, Y, Zhang, Y, Derewenda, U, Liu, X, Minor, W, Nakamoto, R.K, Somlyo, A.V, Somlyo, A.P, Derewenda, Z.S. 登録日 1997-03-13 公開日 1998-03-18 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Crystal structure of RhoA-GDP and its functional implications. Nat.Struct.Biol., 4, 1997

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