7ACF

CRYSTAL STRUCTURE OF CRYSTAL FORM 2 OF AN ACTIVE KRAS G12D (GPPCP) DIMER IN COMPLEX WITH BI-5747

Summary for 7ACF

• Entry DOI: 10.2210/pdb7acf/pdb
• Descriptor: GTPase KRas, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER, ... (5 entities in total)
• Functional Keywords: vienna, ppi, kras; dimer, signaling protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 4
• Total formula weight: 81067.01

Authors

Kessler, D. (deposition date: 2020-09-10, release date: 2020-11-18, Last modification date: 2024-01-31)

• Primary citation: Kessler, D.,Gollner, A.,Gmachl, M.,Mantoulidis, A.,Martin, L.J.,Zoephel, A.,Mayer, M.,Covini, D.,Fischer, S.,Gerstberger, T.,Gmaschitz, T.,Goodwin, C.,Greb, P.,Haering, D.,Hela, W.,Hoffmann, J.,Karolyi-Oezguer, J.,Knesl, P.,Kornigg, S.,Koegl, M.,Kousek, R.,Lamarre, L.,Moser, F.,Munico-Martinez, S.,Peinsipp, C.,Phan, J.,Rinnenthal, J.,Sai, J.,Salamon, C.,Scherbantin, Y.,Schipany, K.,Schnitzer, R.,Schrenk, A.,Sharps, B.,Siszler, G.,Sun, Q.,Waterson, A.,Wolkerstorfer, B.,Zeeb, M.,Pearson, M.,Fesik, S.W.,McConnell, D.B.; Reply to Tran et al.: Dimeric KRAS protein-protein interaction stabilizers.; Proc. Natl. Acad. Sci. U.S.A., 117:3365-3367, 2020; DOI: 10.1073/pnas.1921236117

Experimental method

X-RAY DIFFRACTION (1.91 Å)