6MNX
Structural basis of impaired hydrolysis in KRAS Q61H mutant
Summary for 6MNX
Entry DOI | 10.2210/pdb6mnx/pdb |
Descriptor | GTPase KRas, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... (4 entities in total) |
Functional Keywords | gtpase kras hydrolysis, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 6 |
Total formula weight | 118975.57 |
Authors | Bera, A.K.,Westover, K.D. (deposition date: 2018-10-03, release date: 2020-04-15, Last modification date: 2023-10-11) |
Primary citation | Zhou, Z.W.,Ambrogio, C.,Bera, A.K.,Li, Q.,Li, X.X.,Li, L.,Son, J.,Gondi, S.,Li, J.,Campbell, E.,Jin, H.,Okoro, J.J.,Xu, C.X.,Janne, P.A.,Westover, K.D. KRASQ61HPreferentially Signals through MAPK in a RAF Dimer-Dependent Manner in Non-Small Cell Lung Cancer. Cancer Res., 80:3719-3731, 2020 Cited by PubMed: 32605999DOI: 10.1158/0008-5472.CAN-20-0448 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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