6MNX
Structural basis of impaired hydrolysis in KRAS Q61H mutant
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | GTPase KRas | polymer | 169 | 19281.8 | 6 | UniProt (P01116) Pfam (PF00071) | Homo sapiens (Human) | K-Ras 2,Ki-Ras,c-K-ras,c-Ki-ras |
| 2 | G, I, K, M, O... (A, B, C, D, E...) | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 6 | Chemie (GTP) PubChem (177679032) PubChem (135400627) PubChem (135487750) PubChem (136088935) PubChem (136803486) PubChem (135398633) PubChem (135544356) PubChem (135547949) PubChem (135600366) PubChem (135749822) PubChem (136005188) PubChem (136073923) PubChem (136240914) PubChem (136664747) PubChem (136772743) PubChem (136772744) PubChem (136803487) PubChem (137286749) PubChem (164715984) PubChem (171699466) | |||
| 3 | H, J, L, N, P... (A, B, C, D, E...) | MAGNESIUM ION | non-polymer | 24.3 | 6 | Chemie (MG) PubChem (888) | |||
| 4 | S, T, U, V, W... (A, B, C, D, E...) | water | water | 18.0 | 177 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F: 1 - 169 (UniProt: P01116)
| PDB | External Database | Details |
|---|---|---|
| His 61 | Gln 61 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 115690.7 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 3284.9 | |
| All* | Total formula weight | 118975.6 |
