6MNX

Structural basis of impaired hydrolysis in KRAS Q61H mutant

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E... (A, B, C, D, E...)	GTPase KRas	polymer	169	19281.8	6	UniProt (P01116) Pfam (PF00071)	Homo sapiens (Human)	K-Ras 2,Ki-Ras,c-K-ras,c-Ki-ras
2	G, I, K, M, O... (A, B, C, D, E...)	GUANOSINE-5'-TRIPHOSPHATE	non-polymer		523.2	6	Chemie (GTP)
3	H, J, L, N, P... (A, B, C, D, E...)	MAGNESIUM ION	non-polymer		24.3	6	Chemie (MG)
4	S, T, U, V, W... (A, B, C, D, E...)	water	water		18.0	177	Chemie (HOH)

Sequence modifications

A, B, C, D, E, F: 1 - 169 (UniProt: P01116)

PDB	External Database	Details
His 61	Gln 61	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	115690.7
Non-Polymers*	Number of molecules	12
	Total formula weight	3284.9
All*	Total formula weight	118975.6

*Water molecules are not included.