6N2K
Tetrahydropyridopyrimidines as Covalent Inhibitors of KRAS-G12C
Summary for 6N2K
Entry DOI | 10.2210/pdb6n2k/pdb |
Related | 6N2J |
Descriptor | GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | kras proto-oncogene, gtpase, oncoprotein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 20338.94 |
Authors | Vigers, G.P. (deposition date: 2018-11-13, release date: 2018-12-12, Last modification date: 2023-10-11) |
Primary citation | Fell, J.B.,Fischer, J.P.,Baer, B.R.,Ballard, J.,Blake, J.F.,Bouhana, K.,Brandhuber, B.J.,Briere, D.M.,Burgess, L.E.,Burkard, M.R.,Chiang, H.,Chicarelli, M.J.,Davidson, K.,Gaudino, J.J.,Hallin, J.,Hanson, L.,Hee, K.,Hicken, E.J.,Hinklin, R.J.,Marx, M.A.,Mejia, M.J.,Olson, P.,Savechenkov, P.,Sudhakar, N.,Tang, T.P.,Vigers, G.P.,Zecca, H.,Christensen, J.G. Discovery of Tetrahydropyridopyrimidines as Irreversible Covalent Inhibitors of KRAS-G12C with In Vivo Activity. ACS Med Chem Lett, 9:1230-1234, 2018 Cited by PubMed: 30613331DOI: 10.1021/acsmedchemlett.8b00382 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.72 Å) |
Structure validation
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