2ILP
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![BU of 2ilp by Molmil](/molmil-images/mine/2ilp) | |
5V8R
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3DSE
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4KS6
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![BU of 4ks6 by Molmil](/molmil-images/mine/4ks6) | Crystal structure of the catalytic domain of botulinum neurotoxin BoNT/A C134S mutant with covalent inhibitor that modifies Cys-165 causing disorder in 166-174 stretch | 分子名称: | 1,2-ETHANEDIOL, Botulinum neurotoxin A light chain, DI(HYDROXYETHYL)ETHER, ... | 著者 | Stura, E.A, Vera, L, Guitot, K, Dive, V. | 登録日 | 2013-05-17 | 公開日 | 2014-06-25 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | 主引用文献 | Covalent modification of the active site cysteine stresses Clostridium botulinum neurotoxin A To be Published
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2IMA
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![BU of 2ima by Molmil](/molmil-images/mine/2ima) | |
4ZJX
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2ISH
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![BU of 2ish by Molmil](/molmil-images/mine/2ish) | |
2IMC
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![BU of 2imc by Molmil](/molmil-images/mine/2imc) | |
2ISG
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![BU of 2isg by Molmil](/molmil-images/mine/2isg) | |
5JLV
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![BU of 5jlv by Molmil](/molmil-images/mine/5jlv) | Receptor binding domain of Botulinum neurotoxin A in complex with human glycosylated SV2C | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, ... | 著者 | Yao, G, Zhang, S, Mahrhold, S, Lam, K, Stern, D, Bagramyan, K, Perry, K, Kalkum, M, Rummel, A, Dong, M, Jin, R. | 登録日 | 2016-04-27 | 公開日 | 2016-06-15 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | N-linked glycosylation of SV2 is required for binding and uptake of botulinum neurotoxin A. Nat.Struct.Mol.Biol., 23, 2016
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5TPC
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![BU of 5tpc by Molmil](/molmil-images/mine/5tpc) | Binding domain of BoNT/A complexed with ganglioside | 分子名称: | Botulinum neurotoxin type A, N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose, N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-galactopyranose | 著者 | Berntsson, R.P.-A, Svensson, L.M, Stenmark, P. | 登録日 | 2016-10-20 | 公開日 | 2017-01-18 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Glycans Confer Specificity to the Recognition of Ganglioside Receptors by Botulinum Neurotoxin A. J. Am. Chem. Soc., 139, 2017
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7L6V
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6UL6
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![BU of 6ul6 by Molmil](/molmil-images/mine/6ul6) | |
7N18
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![BU of 7n18 by Molmil](/molmil-images/mine/7n18) | Clostridium botulinum Neurotoxin Serotype A Light Chain Inhibited by a Chiral Hydroxamic Acid | 分子名称: | (3R)-3-(4-chlorophenyl)-N,5-dihydroxypentanamide, (3S)-3-(4-chlorophenyl)-N,5-dihydroxypentanamide, Botulinum neurotoxin type A, ... | 著者 | Silvaggi, N.R, Allen, K.N. | 登録日 | 2021-05-27 | 公開日 | 2022-07-06 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | 主引用文献 | Use of Crystallography and Molecular Modeling for the Inhibition of the Botulinum Neurotoxin A Protease. Acs Med.Chem.Lett., 12, 2021
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5V8U
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1XTG
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![BU of 1xtg by Molmil](/molmil-images/mine/1xtg) | |
5VGX
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![BU of 5vgx by Molmil](/molmil-images/mine/5vgx) | |
2ISE
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![BU of 2ise by Molmil](/molmil-images/mine/2ise) | |
1XTF
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![BU of 1xtf by Molmil](/molmil-images/mine/1xtf) | |
6UI1
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![BU of 6ui1 by Molmil](/molmil-images/mine/6ui1) | Crystal structure of BoNT/A-LCHn domain in complex with VHH ciA-D12, ciA-B5, and ciA-H7 | 分子名称: | BoNT/A, ciA-B5, ciA-D12, ... | 著者 | Lam, K, Jin, R. | 登録日 | 2019-09-29 | 公開日 | 2020-03-04 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.20000863 Å) | 主引用文献 | Structural Insights into Rational Design of Single-Domain Antibody-Based Antitoxins against Botulinum Neurotoxins Cell Rep, 30, 2020
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4JRA
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![BU of 4jra by Molmil](/molmil-images/mine/4jra) | CRYSTAL STRUCTURE OF THE BOTULINUM NEUROTOXIN A RECEPTOR-BINDING DOMAIN IN COMPLEX WITH THE LUMINAL DOMAIN Of SV2C | 分子名称: | Botulinum neurotoxin type A, CHLORIDE ION, SODIUM ION, ... | 著者 | Benoit, R.M, Frey, D, Wieser, M.M, Jaussi, R, Schertler, G.F.X, Capitani, G, Kammerer, R.A. | 登録日 | 2013-03-21 | 公開日 | 2013-11-20 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural basis for recognition of synaptic vesicle protein 2C by botulinum neurotoxin A. Nature, 505, 2014
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4IQP
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![BU of 4iqp by Molmil](/molmil-images/mine/4iqp) | Crystal Structure of HCRA-W1266A | 分子名称: | Botulinum neurotoxin type A, GLYCEROL | 著者 | Fu, Z, Kroken, A.R, Barbieri, J.T, Kim, J.-J.P. | 登録日 | 2013-01-12 | 公開日 | 2013-05-29 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Enhancing the Protective Immune Response against Botulism. Infect.Immun., 81, 2013
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3NF3
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![BU of 3nf3 by Molmil](/molmil-images/mine/3nf3) | |
2IMB
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![BU of 2imb by Molmil](/molmil-images/mine/2imb) | |
4HEV
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![BU of 4hev by Molmil](/molmil-images/mine/4hev) | Clostridium Botulinum Serotype A Light Chain Inhibited By Adamantane Hydroxamate | 分子名称: | Botulinum neurotoxin type A light chain, N-hydroxy-2-[(3S,5S,7S)-tricyclo[3.3.1.1~3,7~]dec-1-yl]acetamide, ZINC ION | 著者 | Silvaggi, N.R, Allen, K.N. | 登録日 | 2012-10-04 | 公開日 | 2013-01-23 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Evaluation of adamantane hydroxamates as botulinum neurotoxin inhibitors: synthesis, crystallography, modeling, kinetic and cellular based studies. Bioorg.Med.Chem., 21, 2013
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