2IMA

Clostridium botulinum Neurotoxin Serotype A Light Chain Inhibited by 2,4-dichlorocinnamic hydroxamate

Summary for 2IMA

Entry DOI	10.2210/pdb2ima/pdb
Related	2ILP 2IMB 2IMC
Descriptor	Botulinum neurotoxin A light-chain, ZINC ION, (2E)-3-(2,4-DICHLOROPHENYL)-N-HYDROXYACRYLAMIDE, ... (4 entities in total)
Functional Keywords	clostridium botulinum neurotoxin serotype a, protease inhibitors, substrate specificity, substrate switching, hydrolase
Biological source	Clostridium botulinum
Total number of polymer chains	2
Total formula weight	102229.49
Authors	Silvaggi, N.R.,Allen, K.N. (deposition date: 2006-10-04, release date: 2007-06-05, Last modification date: 2024-02-21)
Primary citation	Silvaggi, N.R.,Boldt, G.E.,Hixon, M.S.,Kennedy, J.P.,Tzipori, S.,Janda, K.D.,Allen, K.N. Structures of Clostridium botulinum Neurotoxin Serotype A Light Chain Complexed with Small-Molecule Inhibitors Highlight Active-Site Flexibility. Chem.Biol., 14:533-542, 2007 Cited by PubMed: 17524984 DOI: 10.1016/j.chembiol.2007.03.014 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.94 Å)

Structure validation