4KS6
Crystal structure of the catalytic domain of botulinum neurotoxin BoNT/A C134S mutant with covalent inhibitor that modifies Cys-165 causing disorder in 166-174 stretch
Summary for 4KS6
Entry DOI | 10.2210/pdb4ks6/pdb |
Related | 4EJ5 4EL4 4ELC 4KTX |
Related PRD ID | PRD_001078 |
Descriptor | Botulinum neurotoxin A light chain, Peptide inhibitor MPT-DPP-DAR-G-DPN-NH2, ZINC ION, ... (9 entities in total) |
Functional Keywords | clostridial neurotoxin zinc protease, peptidase_m27, snap 25, covalent inhibition, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Clostridium botulinum A More |
Cellular location | Botulinum neurotoxin A light chain: Secreted. Botulinum neurotoxin A heavy chain: Secreted: A5HZZ9 |
Total number of polymer chains | 2 |
Total formula weight | 52323.25 |
Authors | Stura, E.A.,Vera, L.,Guitot, K.,Dive, V. (deposition date: 2013-05-17, release date: 2014-06-25, Last modification date: 2023-09-20) |
Primary citation | Guitot, K.,Vera, L.,Le Roux, L.,Bregant, S.,Ptchelkine, D.,Beau, F.,Stura, E.A.,Dive, V. Covalent modification of the active site cysteine stresses Clostridium botulinum neurotoxin A To be Published, |
Experimental method | X-RAY DIFFRACTION (1.93 Å) |
Structure validation
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