7N18

Clostridium botulinum Neurotoxin Serotype A Light Chain Inhibited by a Chiral Hydroxamic Acid

Summary for 7N18

• Entry DOI: 10.2210/pdb7n18/pdb
• Descriptor: Botulinum neurotoxin type A, ZINC ION, (3R)-3-(4-chlorophenyl)-N,5-dihydroxypentanamide, ... (5 entities in total)
• Functional Keywords: botulinum protease, bont/a, inhibitor, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor
• Biological source: Clostridium botulinum
• Total number of polymer chains: 2
• Total formula weight: 102549.05

Authors

Silvaggi, N.R.,Allen, K.N. (deposition date: 2021-05-27, release date: 2022-07-06, Last modification date: 2024-01-17)

• Primary citation: Turner, L.D.,Nielsen, A.L.,Lin, L.,Campedelli, A.J.,Silvaggi, N.R.,Chen, J.S.,Wakefield, A.E.,Allen, K.N.,Janda, K.D.; Use of Crystallography and Molecular Modeling for the Inhibition of the Botulinum Neurotoxin A Protease.; Acs Med.Chem.Lett., 12:1318-1324, 2021; PubMed: 34413962; DOI: 10.1021/acsmedchemlett.1c00325

Experimental method

X-RAY DIFFRACTION (2.03 Å)