4HEV
Clostridium Botulinum Serotype A Light Chain Inhibited By Adamantane Hydroxamate
Summary for 4HEV
Entry DOI | 10.2210/pdb4hev/pdb |
Descriptor | Botulinum neurotoxin type A light chain, ZINC ION, N-hydroxy-2-[(3S,5S,7S)-tricyclo[3.3.1.1~3,7~]dec-1-yl]acetamide, ... (4 entities in total) |
Functional Keywords | zn2+-dependent metalloprotease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Clostridium botulinum |
Cellular location | Botulinum neurotoxin A light chain: Secreted. Botulinum neurotoxin A heavy chain: Secreted: P10845 |
Total number of polymer chains | 2 |
Total formula weight | 101753.48 |
Authors | Silvaggi, N.R.,Allen, K.N. (deposition date: 2012-10-04, release date: 2013-01-23, Last modification date: 2023-09-20) |
Primary citation | Silhar, P.,Silvaggi, N.R.,Pellett, S.,Johnson, E.A.,Allen, K.N.,Janda, K.D. Evaluation of adamantane hydroxamates as botulinum neurotoxin inhibitors: synthesis, crystallography, modeling, kinetic and cellular based studies. Bioorg.Med.Chem., 21:1344-1348, 2013 Cited by PubMed: 23340139DOI: 10.1016/j.bmc.2012.12.001 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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