5JLV
Receptor binding domain of Botulinum neurotoxin A in complex with human glycosylated SV2C
Summary for 5JLV
Entry DOI | 10.2210/pdb5jlv/pdb |
Descriptor | Botulinum neurotoxin type A, Synaptic vesicle glycoprotein 2C, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total) |
Functional Keywords | glycosylation, botulinum neurotoxin, receptor binding domain, hydrolase |
Biological source | Clostridium botulinum More |
Total number of polymer chains | 4 |
Total formula weight | 128923.30 |
Authors | Yao, G.,Zhang, S.,Mahrhold, S.,Lam, K.,Stern, D.,Bagramyan, K.,Perry, K.,Kalkum, M.,Rummel, A.,Dong, M.,Jin, R. (deposition date: 2016-04-27, release date: 2016-06-15, Last modification date: 2023-09-27) |
Primary citation | Yao, G.,Zhang, S.,Mahrhold, S.,Lam, K.H.,Stern, D.,Bagramyan, K.,Perry, K.,Kalkum, M.,Rummel, A.,Dong, M.,Jin, R. N-linked glycosylation of SV2 is required for binding and uptake of botulinum neurotoxin A. Nat.Struct.Mol.Biol., 23:656-662, 2016 Cited by PubMed: 27294781DOI: 10.1038/nsmb.3245 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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