5JLV
Receptor binding domain of Botulinum neurotoxin A in complex with human glycosylated SV2C
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Botulinum neurotoxin type A | polymer | 428 | 49877.5 | 2 | UniProt (P10845) Pfam (PF07953) Pfam (PF07951) UniProt (by SIFTS) (P0DPI1) | Clostridium botulinum | BoNT/A,Bontoxilysin-A,BOTOX |
| 2 | C, D (C, D) | Synaptic vesicle glycoprotein 2C | polymer | 117 | 13590.9 | 2 | UniProt (Q496J9) Pfam (PF13599) | Homo sapiens (Human) | |
| 3 | E (E) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 732.7 | 1 | In PDB GlyTouCan (G32152BH) | |||
| 4 | F (F) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 570.5 | 1 | In PDB GlyTouCan (G21290RB) | |||
| 5 | G, J, K (A, B) | ACETATE ION | non-polymer | 59.0 | 3 | Chemie (ACT) | |||
| 6 | H, I, L (A, B) | PHOSPHATE ION | non-polymer | 95.0 | 3 | Chemie (PO4) | |||
| 7 | M (C) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
| 8 | N, O, P, Q (A, B, C, D) | water | water | 18.0 | 659 | Chemie (HOH) |
Sequence modifications
A, B: 872 - 1296 (UniProt: P10845)
C, D: 473 - 567 (UniProt: Q496J9)
| PDB | External Database | Details |
|---|---|---|
| Gly 869 | - | expression tag |
| Pro 870 | - | expression tag |
| Met 871 | - | expression tag |
| Ala 1158 | Thr 1158 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Ser 451 | - | expression tag |
| His 452 | - | expression tag |
| His 453 | - | expression tag |
| His 454 | - | expression tag |
| His 455 | - | expression tag |
| His 456 | - | expression tag |
| His 457 | - | expression tag |
| His 458 | - | expression tag |
| His 459 | - | expression tag |
| His 460 | - | expression tag |
| Ser 461 | - | expression tag |
| Gly 462 | - | expression tag |
| Gly 463 | - | expression tag |
| Gly 464 | - | expression tag |
| Ser 465 | - | expression tag |
| Gly 466 | - | expression tag |
| Gly 467 | - | expression tag |
| Gly 468 | - | expression tag |
| Ile 469 | - | expression tag |
| Glu 470 | - | expression tag |
| Gly 471 | - | expression tag |
| Arg 472 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 126936.8 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 1303.2 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 683.3 | |
| All* | Total formula weight | 128923.3 |
