2F3Y
 
 | | Calmodulin/IQ domain complex | | 分子名称: | CALCIUM ION, Calmodulin, MAGNESIUM ION, ... | | 著者 | Fallon, J.L, Quiocho, F.A. | | 登録日 | 2005-11-22 | | 公開日 | 2005-12-27 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | | 主引用文献 | Structure of Calmodulin Bound to the Hydrophobic IQ Domain of the Cardiac Ca(v)1.2 Calcium Channel.
Structure, 13, 2005
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2F3Z
 | | Calmodulin/IQ-AA domain complex | | 分子名称: | CALCIUM ION, Calmodulin, Voltage-dependent L-type calcium channel alpha-1C subunit | | 著者 | Fallon, J.L, Quiocho, F.A. | | 登録日 | 2005-11-22 | | 公開日 | 2005-12-27 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Structure of Calmodulin Bound to the Hydrophobic IQ Domain of the Cardiac Ca(v)1.2 Calcium Channel.
Structure, 13, 2005
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6DAD
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6U3A
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6U3B
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5V2Q
 | | CaV beta2a subunit: CaV1.2 AID-CEN complex | | 分子名称: | 1,3-bis(bromomethyl)benzene, CHLORIDE ION, Voltage-dependent L-type calcium channel subunit alpha-1C, ... | | 著者 | Findeisen, F, Campiglio, M, Jo, H, Rumpf, C.H, Pope, L, Flucher, B, Degrado, W.F, Minor, D.L. | | 登録日 | 2017-03-06 | | 公開日 | 2017-07-19 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Stapled Voltage-Gated Calcium Channel (CaV) alpha-Interaction Domain (AID) Peptides Act As Selective Protein-Protein Interaction Inhibitors of CaV Function.
ACS Chem Neurosci, 8, 2017
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6U3D
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6DAE
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5V2P
 | | CaV beta2a subunit: CaV1.2 AID-CAP complex | | 分子名称: | 1,3-bis(bromomethyl)benzene, NICKEL (II) ION, PENTAETHYLENE GLYCOL, ... | | 著者 | Findeisen, F, Campiglio, M, Jo, H, Rumpf, C.H, Pope, L, Flucher, B, Degrado, W.F, Minor, D.L. | | 登録日 | 2017-03-06 | | 公開日 | 2017-07-19 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Stapled Voltage-Gated Calcium Channel (CaV) alpha-Interaction Domain (AID) Peptides Act As Selective Protein-Protein Interaction Inhibitors of CaV Function.
ACS Chem Neurosci, 8, 2017
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2BE6
 | | 2.0 A crystal structure of the CaV1.2 IQ domain-Ca/CaM complex | | 分子名称: | CALCIUM ION, Calmodulin 2, NICKEL (II) ION, ... | | 著者 | Van Petegem, F, Chatelain, F.C, Minor Jr, D.L. | | 登録日 | 2005-10-23 | | 公開日 | 2005-11-15 | | 最終更新日 | 2024-05-22 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Insights into voltage-gated calcium channel regulation from the structure of the Ca(V)1.2 IQ domain-Ca(2+)/calmodulin complex
Nat.Struct.Mol.Biol., 12, 2005
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1T0J
 | | Crystal structure of a complex between voltage-gated calcium channel beta2a subunit and a peptide of the alpha1c subunit | | 分子名称: | CHLORIDE ION, Voltage-dependent L-type calcium channel alpha-1C subunit, voltage-gated calcium channel subunit beta2a | | 著者 | Van Petegem, F, Clark, K, Chatelain, F, Minor Jr, D. | | 登録日 | 2004-04-09 | | 公開日 | 2004-06-15 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structure of a complex between a voltage-gated calcium channel beta-subunit and an alpha-subunit domain.
Nature, 429, 2004
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3G43
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6DAF
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6U39
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3OXQ
 | | Crystal Structure of Ca2+/CaM-CaV1.2 pre-IQ/IQ domain complex | | 分子名称: | CALCIUM ION, Calmodulin, Voltage-dependent L-type calcium channel subunit alpha-1C | | 著者 | Kim, E.Y, Rumpf, C.H, Van Petegem, F, Arant, R, Findeisen, F, Cooley, E.S, Isacoff, E.Y, Minor, D.L. | | 登録日 | 2010-09-21 | | 公開日 | 2010-11-03 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | | 主引用文献 | Multiple C-terminal tail Ca(2+)/CaMs regulate Ca(V)1.2 function but do not mediate channel dimerization.
Embo J., 29, 2010
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8WE6
 | | Human L-type voltage-gated calcium channel Cav1.2 at 2.9 Angstrom resolution | | 分子名称: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Gao, S, Yao, X, Yan, N. | | 登録日 | 2023-09-17 | | 公開日 | 2023-12-06 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Structural basis for human Ca v 1.2 inhibition by multiple drugs and the neurotoxin calciseptine.
Cell, 186, 2023
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8WE8
 | | Human L-type voltage-gated calcium channel Cav1.2 in the presence of calciseptine, amlodipine and pinaverium at 2.9 Angstrom resolution | | 分子名称: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Gao, S, Yao, X, Yan, N. | | 登録日 | 2023-09-17 | | 公開日 | 2023-12-06 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Structural basis for human Ca v 1.2 inhibition by multiple drugs and the neurotoxin calciseptine.
Cell, 186, 2023
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8WE9
 | | Human L-type voltage-gated calcium channel Cav1.2 (Class I) in the presence of pinaverium at 3.0 Angstrom resolution | | 分子名称: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Gao, S, Yao, X, Fan, X, Yan, N. | | 登録日 | 2023-09-17 | | 公開日 | 2023-12-06 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Structural basis for human Ca v 1.2 inhibition by multiple drugs and the neurotoxin calciseptine.
Cell, 186, 2023
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8FD7
 | | Structure of the human L-type voltage-gated calcium channel Cav1.2 complexed with gabapentin | | 分子名称: | (2R)-3-{[(R)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(dodecanoyloxy)propyl heptadecanoate, (2S)-3-{[(R)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(dodecanoyloxy)propyl dodecanoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Chen, Z, Mondal, A, Minor, D.L. | | 登録日 | 2022-12-02 | | 公開日 | 2023-03-22 | | 最終更新日 | 2023-07-05 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Structural basis for Ca V alpha 2 delta :gabapentin binding.
Nat.Struct.Mol.Biol., 30, 2023
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8WE7
 | | Human L-type voltage-gated calcium channel Cav1.2 in the presence of calciseptine at 3.2 Angstrom resolution | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Gao, S, Yao, X, Yan, N. | | 登録日 | 2023-09-17 | | 公開日 | 2023-12-06 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Structural basis for human Ca v 1.2 inhibition by multiple drugs and the neurotoxin calciseptine.
Cell, 186, 2023
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8WEA
 | | Human L-type voltage-gated calcium channel Cav1.2 (Class II) in the presence of pinaverium at 3.2 Angstrom resolution | | 分子名称: | (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Gao, S, Yao, X, Fan, X, Yan, N. | | 登録日 | 2023-09-17 | | 公開日 | 2023-12-06 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Structural basis for human Ca v 1.2 inhibition by multiple drugs and the neurotoxin calciseptine.
Cell, 186, 2023
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8FHS
 | | Human L-type voltage-gated calcium channel Cav1.2 in the presence of amiodarone and sofosbuvir at 3.3 Angstrom resolution | | 分子名称: | (2-butyl-1-benzofuran-3-yl){4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl}methanone, 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Gao, S, Yao, X, Yan, N. | | 登録日 | 2022-12-15 | | 公開日 | 2023-12-13 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Structural basis for human Ca v 1.2 inhibition by multiple drugs and the neurotoxin calciseptine.
Cell, 186, 2023
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8EOG
 | | Structure of the human L-type voltage-gated calcium channel Cav1.2 complexed with L-leucine | | 分子名称: | (2R)-3-{[(R)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(dodecanoyloxy)propyl dodecanoate, (2R)-3-{[(R)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(dodecanoyloxy)propyl heptadecanoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Chen, Z, Mondal, A, Abderemane-Ali, F, Minor, D.L. | | 登録日 | 2022-10-03 | | 公開日 | 2023-05-24 | | 最終更新日 | 2023-07-26 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | EMC chaperone-Ca V structure reveals an ion channel assembly intermediate.
Nature, 619, 2023
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8EOI
 | | Structure of a human EMC:human Cav1.2 channel complex in GDN detergent | | 分子名称: | (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Chen, Z, Mondal, A, Abderemane-Ali, F, Minor, D.L. | | 登録日 | 2022-10-03 | | 公開日 | 2023-05-24 | | 最終更新日 | 2023-07-26 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | EMC chaperone-Ca V structure reveals an ion channel assembly intermediate.
Nature, 619, 2023
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8HLP
 | | Cryo-EM structure of human high-voltage activated L-type calcium channel CaV1.2 (apo) | | 分子名称: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | 著者 | Wei, Y, Yu, Z, Zhao, Y. | | 登録日 | 2022-11-30 | | 公開日 | 2024-04-24 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Structural bases of inhibitory mechanism of Ca V 1.2 channel inhibitors.
Nat Commun, 15, 2024
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