8EOI

Structure of a human EMC:human Cav1.2 channel complex in GDN detergent

Summary for 8EOI

• Entry DOI: 10.2210/pdb8eoi/pdb
• EMDB information: 28376
• Descriptor: ER membrane protein complex subunit 1, Voltage-dependent L-type calcium channel subunit beta-3, ER membrane protein complex subunit 4, ... (14 entities in total)
• Functional Keywords: endoplasmic reticulum membrane protein complex, voltage-gated calcium channel, holdase, biogenesis, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 11
• Total formula weight: 483944.81

Authors

Chen, Z.,Mondal, A.,Abderemane-Ali, F.,Minor, D.L. (deposition date: 2022-10-03, release date: 2023-05-24, Last modification date: 2023-07-26)

• Primary citation: Chen, Z.,Mondal, A.,Abderemane-Ali, F.,Jang, S.,Niranjan, S.,Montano, J.L.,Zaro, B.W.,Minor Jr., D.L.; EMC chaperone-Ca V structure reveals an ion channel assembly intermediate.; Nature, 619:410-419, 2023; PubMed: 37196677; DOI: 10.1038/s41586-023-06175-5

Experimental method

ELECTRON MICROSCOPY (3.4 Å)