8EOG

Structure of the human L-type voltage-gated calcium channel Cav1.2 complexed with L-leucine

Summary for 8EOG

• Entry DOI: 10.2210/pdb8eog/pdb
• EMDB information: 28375 28561 28564
• Descriptor: Voltage-dependent calcium channel subunit alpha-2/delta-1, CHOLESTEROL, (2R)-3-{[(R)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(dodecanoyloxy)propyl dodecanoate, ... (13 entities in total)
• Functional Keywords: voltage-gated calcium channel, cav alpha2delta, drug binding, gabapentinoid, membrane protein
• Biological source: Oryctolagus cuniculus (rabbit); More
• Total number of polymer chains: 3
• Total formula weight: 316630.21

Authors

Chen, Z.,Mondal, A.,Abderemane-Ali, F.,Minor, D.L. (deposition date: 2022-10-03, release date: 2023-05-24, Last modification date: 2023-07-26)

• Primary citation: Chen, Z.,Mondal, A.,Abderemane-Ali, F.,Jang, S.,Niranjan, S.,Montano, J.L.,Zaro, B.W.,Minor Jr., D.L.; EMC chaperone-Ca V structure reveals an ion channel assembly intermediate.; Nature, 619:410-419, 2023; PubMed: 37196677; DOI: 10.1038/s41586-023-06175-5

Experimental method

ELECTRON MICROSCOPY (3.3 Å)