8EOG
Structure of the human L-type voltage-gated calcium channel Cav1.2 complexed with L-leucine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (D) | Voltage-dependent calcium channel subunit alpha-2/delta-1 | polymer | 1050 | 118941.7 | 1 | UniProt (P13806) Pfam (PF08399) Pfam (PF00092) Pfam (PF08473) | Oryctolagus cuniculus (rabbit) | Voltage-gated calcium channel subunit alpha-2/delta-1 |
| 2 | B (K) | Isoform 20 of Voltage-dependent L-type calcium channel subunit alpha-1C | polymer | 1499 | 170774.9 | 1 | UniProt (Q13936-20) Pfam (PF00520) Pfam (PF08016) Pfam (PF16905) Pfam (PF08763) UniProt (by SIFTS) (Q13936) | Homo sapiens (human) | Calcium channel,L type,alpha-1 polypeptide,isoform 1,cardiac muscle,Voltage-gated calcium channel subunit alpha Cav1.2 |
| 3 | C (C) | Voltage-dependent L-type calcium channel subunit beta-3 | polymer | 191 | 21667.2 | 1 | UniProt (P54286) Pfam (PF00625) | Oryctolagus cuniculus (rabbit) | CAB3,Calcium channel voltage-dependent subunit beta 3 |
| 4 | D (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 627.6 | 1 | In PDB GlyTouCan (G47362BJ) | |||
| 5 | E, F (B, E) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
| 6 | G, H, I, J, K (D) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 5 | Chemie (NAG) | |||
| 7 | L, T, U (D, K) | CALCIUM ION | non-polymer | 40.1 | 3 | Chemie (CA) | |||
| 8 | M (D) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 9 | N (D) | LEUCINE | non-polymer | 131.2 | 1 | Chemie (LEU) | |||
| 10 | O, P, Q (K) | CHOLESTEROL | non-polymer | 386.7 | 3 | Chemie (CLR) | |||
| 11 | R (K) | (2R)-3-{[(R)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(dodecanoyloxy)propyl dodecanoate | non-polymer | 579.7 | 1 | Chemie (WNZ) | |||
| 12 | S (K) | (2R)-3-{[(R)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(dodecanoyloxy)propyl heptadecanoate | non-polymer | 649.9 | 1 | Chemie (WO9) | |||
| 13 | V (K) | water | water | 18.0 | 3 | Chemie (HOH) |
Sequence modifications
D: 29 - 1078 (UniProt: P13806)
| PDB | External Database | Details |
|---|---|---|
| - | Ser 620 | deletion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 311383.8 | |
| Branched | Number of molecules | 3 |
| Total formula weight | 1476.4 | |
| Non-Polymers* | Number of molecules | 15 |
| Total formula weight | 3770.0 | |
| All* | Total formula weight | 316630.2 |
