6DAE

2.0 Angstrom crystal structure of the D95V Ca/CaM:CaV1.2 IQ domain complex

Summary for 6DAE

Entry DOI	10.2210/pdb6dae/pdb
Descriptor	Calmodulin-1, Voltage-dependent L-type calcium channel subunit alpha-1C, CALCIUM ION, ... (4 entities in total)
Functional Keywords	calmodulin, mutant, complex, calcium binding protein-membrane protein complex, calcium binding protein/membrane protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	42289.19
Authors	Wang, K.,Lu, J.,Van Petegem, F. (deposition date: 2018-05-01, release date: 2018-10-17, Last modification date: 2023-10-04)
Primary citation	Wang, K.,Holt, C.,Lu, J.,Brohus, M.,Larsen, K.T.,Overgaard, M.T.,Wimmer, R.,Van Petegem, F. Arrhythmia mutations in calmodulin cause conformational changes that affect interactions with the cardiac voltage-gated calcium channel. Proc. Natl. Acad. Sci. U.S.A., 115:E10556-E10565, 2018 Cited by PubMed: 30348784 DOI: 10.1073/pnas.1808733115 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation