8FHS

Human L-type voltage-gated calcium channel Cav1.2 in the presence of amiodarone and sofosbuvir at 3.3 Angstrom resolution

Summary for 8FHS

Entry DOI	10.2210/pdb8fhs/pdb
EMDB information	29102
Descriptor	Voltage-dependent L-type calcium channel subunit alpha-1C, 1,2-Distearoyl-sn-glycerophosphoethanolamine, CHOLESTEROL, ... (12 entities in total)
Functional Keywords	cav1.2, channels, calcium ion-selective, transport protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	3
Total formula weight	436014.21
Authors	Gao, S.,Yao, X.,Yan, N. (deposition date: 2022-12-15, release date: 2023-12-13)
Primary citation	Gao, S.,Yao, X.,Chen, J.,Huang, G.,Fan, X.,Xue, L.,Li, Z.,Wu, T.,Zheng, Y.,Huang, J.,Jin, X.,Wang, Y.,Wang, Z.,Yu, Y.,Liu, L.,Pan, X.,Song, C.,Yan, N. Structural basis for human Ca v 1.2 inhibition by multiple drugs and the neurotoxin calciseptine. Cell, 186:5363-5374.e16, 2023 Cited by PubMed: 37972591 DOI: 10.1016/j.cell.2023.10.007 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.3 Å)

Structure validation