8FHS
Human L-type voltage-gated calcium channel Cav1.2 in the presence of amiodarone and sofosbuvir at 3.3 Angstrom resolution
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Voltage-dependent L-type calcium channel subunit alpha-1C | polymer | 2221 | 249242.2 | 1 | UniProt (Q13936) Pfam (PF00520) Pfam (PF16905) Pfam (PF08763) Pfam (PF16885) | Homo sapiens (human) | Calcium channel,L type,alpha-1 polypeptide,isoform 1,cardiac muscle,Voltage-gated calcium channel subunit alpha Cav1.2 |
| 2 | B (D) | Voltage-dependent calcium channel subunit alpha-2/delta-1 | polymer | 1103 | 124692.5 | 1 | UniProt (P54289) Pfam (PF08399) Pfam (PF00092) Pfam (PF08473) | Homo sapiens (human) | Voltage-gated calcium channel subunit alpha-2/delta-1 |
| 3 | C (C) | Voltage-dependent L-type calcium channel subunit beta-3 | polymer | 484 | 54607.9 | 1 | UniProt (P54284) Pfam (PF12052) Pfam (PF00625) | Homo sapiens (human) | CAB3,Calcium channel voltage-dependent subunit beta 3 |
| 4 | D (B) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 627.6 | 1 | In PDB GlyTouCan (G47362BJ) | |||
| 5 | E, G, H (E, G, H) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 3 | In PDB GlyTouCan (G42666HT) | |||
| 6 | F (F) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 830.8 | 1 | In PDB GlyTouCan (G01361SX) | |||
| 7 | I, R (A, D) | CALCIUM ION | non-polymer | 40.1 | 2 | Chemie (CA) PubChem (271) | |||
| 8 | J (A) | (2-butyl-1-benzofuran-3-yl){4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl}methanone | non-polymer | 645.3 | 1 | Chemie (BBI) PubChem (2157) | |||
| 9 | K (A) | Sofosbuvir | non-polymer | 529.5 | 1 | Chemie (WG6) PubChem (176474038) PubChem (176474039) PubChem (176474040) PubChem (176474041) PubChem (176474042) PubChem (176474043) PubChem (176474044) PubChem (25094462) PubChem (25095800) PubChem (45375806) PubChem (45375808) PubChem (59585145) PubChem (45375809) PubChem (67246368) PubChem (67435893) PubChem (67438468) PubChem (67438469) PubChem (68216377) PubChem (49781487) PubChem (72699160) PubChem (73265383) PubChem (73425559) PubChem (67246362) PubChem (67442819) PubChem (176474037) PubChem (89771364) PubChem (90164440) PubChem (90168219) PubChem (90168220) PubChem (90339187) PubChem (90339304) PubChem (90349768) PubChem (73425384) PubChem (89657899) PubChem (90055712) PubChem (90168217) PubChem (91302628) PubChem (117650328) PubChem (117969332) PubChem (122527507) PubChem (134154297) PubChem (117647534) PubChem (117647899) PubChem (118699011) PubChem (118703177) PubChem (118703641) PubChem (118703642) PubChem (118918760) PubChem (138517399) PubChem (145714362) PubChem (146050376) PubChem (146050372) PubChem (153426420) PubChem (154999087) PubChem (125129660) PubChem (125129661) PubChem (125129662) PubChem (160986002) PubChem (126601178) PubChem (168784613) PubChem (129010435) PubChem (129135394) PubChem (129390122) PubChem (129406570) PubChem (129605368) PubChem (130368927) PubChem (131704519) PubChem (131704520) PubChem (134137517) PubChem (134244141) PubChem (137465279) PubChem (137490591) PubChem (137705855) PubChem (137795276) PubChem (138958271) PubChem (140960676) PubChem (144629152) PubChem (144936904) PubChem (145674031) PubChem (145674055) PubChem (145714338) PubChem (145714351) PubChem (145714385) PubChem (146050371) PubChem (152845633) PubChem (152845634) PubChem (152845635) PubChem (152845639) PubChem (156009614) PubChem (162505477) PubChem (163983133) PubChem (170899023) PubChem (170904531) PubChem (171370582) PubChem (173787672) PubChem (173789346) PubChem (173789347) | |||
| 10 | L, N (A) | 1,2-Distearoyl-sn-glycerophosphoethanolamine | non-polymer | 748.1 | 2 | Chemie (3PE) | |||
| 11 | M, O, P, Q (A) | CHOLESTEROL | non-polymer | 386.7 | 4 | Chemie (CLR) PubChem (16219173) PubChem (16758052) PubChem (304) PubChem (176980071) PubChem (40477506) PubChem (40557614) PubChem (42579431) PubChem (42579432) PubChem (18640088) PubChem (1715243) PubChem (1715244) PubChem (45044259) PubChem (23423981) PubChem (49853509) PubChem (50990013) PubChem (52934537) PubChem (56621683) PubChem (191463) PubChem (57915018) PubChem (57939063) PubChem (58428240) PubChem (58445498) PubChem (58663286) PubChem (368063) PubChem (369319) PubChem (44654663) PubChem (59450329) PubChem (59628412) PubChem (59965215) PubChem (71234641) PubChem (59993755) PubChem (60001463) PubChem (66634651) PubChem (68055877) PubChem (68166463) PubChem (68315613) PubChem (46937002) PubChem (70795838) PubChem (70797612) PubChem (70954610) PubChem (70957185) PubChem (71463909) PubChem (638019) PubChem (59274407) PubChem (1549081) PubChem (1553803) PubChem (68311425) PubChem (68311398) PubChem (143173313) PubChem (177156123) PubChem (89951918) PubChem (90224410) PubChem (5997) PubChem (5283629) PubChem (5284644) PubChem (1551269) PubChem (90070115) PubChem (91298236) PubChem (5315842) PubChem (117965027) PubChem (6432564) PubChem (6710666) PubChem (124146240) PubChem (7059399) PubChem (124897607) PubChem (124896959) PubChem (6419195) PubChem (10861996) PubChem (132837164) PubChem (101624109) PubChem (6994560) PubChem (7055705) PubChem (7055706) PubChem (7059398) PubChem (7059400) PubChem (7059635) PubChem (7103033) PubChem (7182477) PubChem (7182478) PubChem (11834483) PubChem (11888915) PubChem (11888914) PubChem (9909206) PubChem (10045721) PubChem (71168115) PubChem (10134774) PubChem (10293553) PubChem (71173031) PubChem (124225449) PubChem (138967089) PubChem (11003580) PubChem (11025495) PubChem (11058155) PubChem (139566851) PubChem (124429284) PubChem (11463329) PubChem (11868624) PubChem (11868625) PubChem (11869366) PubChem (11869367) PubChem (11869368) PubChem (11869369) PubChem (12120344) PubChem (12156156) PubChem (12303135) PubChem (12303148) PubChem (12303156) PubChem (12303159) PubChem (12303160) PubChem (15939944) PubChem (124909223) PubChem (124909224) PubChem (124909225) PubChem (171828367) PubChem (173516975) PubChem (130459183) PubChem (131992107) PubChem (139568882) PubChem (142983773) PubChem (144054483) PubChem (144209461) PubChem (144331236) PubChem (144808354) PubChem (145053568) PubChem (145157652) PubChem (145215073) PubChem (145230478) PubChem (146320991) PubChem (147857230) PubChem (154993519) PubChem (158603858) PubChem (162906452) PubChem (162906453) PubChem (162906454) PubChem (162906455) PubChem (162906456) PubChem (162906457) PubChem (163255768) PubChem (163389210) PubChem (164665303) PubChem (166553771) PubChem (166712004) PubChem (170116175) PubChem (171764280) PubChem (171817101) PubChem (171817104) PubChem (174285573) | |||
| 12 | S, T (D) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 428542.5 | |
| Branched | Number of molecules | 5 |
| Total formula weight | 2731.6 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 4740.1 | |
| All* | Total formula weight | 436014.2 |
