8FHS
Human L-type voltage-gated calcium channel Cav1.2 in the presence of amiodarone and sofosbuvir at 3.3 Angstrom resolution
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Voltage-dependent L-type calcium channel subunit alpha-1C | polymer | 2221 | 249242.2 | 1 | UniProt (Q13936) Pfam (PF00520) Pfam (PF16885) Pfam (PF08016) Pfam (PF16905) Pfam (PF08763) | Homo sapiens (human) | Calcium channel,L type,alpha-1 polypeptide,isoform 1,cardiac muscle,Voltage-gated calcium channel subunit alpha Cav1.2 |
| 2 | B (D) | Voltage-dependent calcium channel subunit alpha-2/delta-1 | polymer | 1103 | 124692.5 | 1 | UniProt (P54289) Pfam (PF08399) Pfam (PF00092) Pfam (PF08473) | Homo sapiens (human) | Voltage-gated calcium channel subunit alpha-2/delta-1 |
| 3 | C (C) | Voltage-dependent L-type calcium channel subunit beta-3 | polymer | 484 | 54607.9 | 1 | UniProt (P54284) Pfam (PF12052) Pfam (PF00625) | Homo sapiens (human) | CAB3,Calcium channel voltage-dependent subunit beta 3 |
| 4 | D (B) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 627.6 | 1 | In PDB GlyTouCan (G47362BJ) | |||
| 5 | E, G, H (E, G, H) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 3 | In PDB GlyTouCan (G42666HT) | |||
| 6 | F (F) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 830.8 | 1 | In PDB GlyTouCan (G01361SX) | |||
| 7 | I, R (A, D) | CALCIUM ION | non-polymer | 40.1 | 2 | Chemie (CA) | |||
| 8 | J (A) | (2-butyl-1-benzofuran-3-yl){4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl}methanone | non-polymer | 645.3 | 1 | Chemie (BBI) | |||
| 9 | K (A) | Sofosbuvir | non-polymer | 529.5 | 1 | Chemie (WG6) | |||
| 10 | L, N (A) | 1,2-Distearoyl-sn-glycerophosphoethanolamine | non-polymer | 748.1 | 2 | Chemie (3PE) | |||
| 11 | M, O, P, Q (A) | CHOLESTEROL | non-polymer | 386.7 | 4 | Chemie (CLR) | |||
| 12 | S, T (D) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 428542.5 | |
| Branched | Number of molecules | 5 |
| Total formula weight | 2731.6 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 4740.1 | |
| All* | Total formula weight | 436014.2 |
