8WE9

Human L-type voltage-gated calcium channel Cav1.2 (Class I) in the presence of pinaverium at 3.0 Angstrom resolution

Summary for 8WE9

• Entry DOI: 10.2210/pdb8we9/pdb
• EMDB information: 37475
• Descriptor: Voltage-dependent L-type calcium channel subunit alpha-1C, 2-acetamido-2-deoxy-beta-D-glucopyranose, [(2R)-1-octadecanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phospho ryl]oxy-propan-2-yl] (8Z)-icosa-5,8,11,14-tetraenoate, ... (11 entities in total)
• Functional Keywords: cav1.2, channels, calcium ion-selective, transport protein, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 432582.05

Authors

Gao, S.,Yao, X.,Fan, X.,Yan, N. (deposition date: 2023-09-17, release date: 2023-12-06)

• Primary citation: Gao, S.,Yao, X.,Chen, J.,Huang, G.,Fan, X.,Xue, L.,Li, Z.,Wu, T.,Zheng, Y.,Huang, J.,Jin, X.,Wang, Y.,Wang, Z.,Yu, Y.,Liu, L.,Pan, X.,Song, C.,Yan, N.; Structural basis for human Ca v 1.2 inhibition by multiple drugs and the neurotoxin calciseptine.; Cell, 186:5363-5374.e16, 2023; PubMed: 37972591; DOI: 10.1016/j.cell.2023.10.007

Experimental method

ELECTRON MICROSCOPY (3 Å)