Loading
PDBj
English日本語简体中文繁體中文한국어
✖
ﾒﾆｭｰPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
PDB: 145 件
4UWJ
DownloadVisualize
BU of 4uwj by Molmil
Crystal structure of Aspergillus fumigatus N-myristoyl transferase in complex with myristoyl CoA and a capped pyrazole sulphonamide ligand
分子名称: 2,6-dichloro-N-(difluoromethyl)-4-[3-(piperidin-4-yl)propyl]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide, GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, TETRADECANOYL-COA
著者Robinson, D.A, Brand, S, Norcross, N.R, Thompson, S, Harrison, J.R, Smith, V.C, Torrie, L.S, McElroy, S.P, Hallyburton, I, Norval, S, Stojanovski, L, Simeons, F.R.C, Frearson, J.A, Brenk, R, Fairlamb, A.H, Ferguson, M.A.J, Wyatt, P.G, Gilbert, I.H, Read, K.D.
登録日2014-08-12
公開日2014-12-03
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Lead optimization of a pyrazole sulfonamide series of Trypanosoma brucei N-myristoyltransferase inhibitors: identification and evaluation of CNS penetrant compounds as potential treatments for stage 2 human African trypanosomiasis.
J. Med. Chem., 57, 2014
4QBJ
DownloadVisualize
BU of 4qbj by Molmil
Crystal structure of N-myristoyl transferase from Aspergillus fumigatus complexed with a synthetic inhibitor
分子名称: 3-[[3-methyl-2-[[2,3,4-tris(fluoranyl)phenoxy]methyl]-1-benzofuran-4-yl]oxy]-N-(pyridin-3-ylmethyl)propan-1-amine, Glycylpeptide N-tetradecanoyltransferase, S-(2-OXO)PENTADECYLCOA, ...
著者Suzuki, M, Shimada, T.
登録日2014-05-08
公開日2015-04-01
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structure of N-myristoyltransferase from Aspergillus fumigatus
Acta Crystallogr.,Sect.D, 71, 2015
1RXT
DownloadVisualize
BU of 1rxt by Molmil
Crystal structure of human myristoyl-CoA:protein N-myristoyltransferase.
分子名称: COBALT (II) ION, Glycylpeptide N-tetradecanoyltransferase 1, SULFATE ION
著者Yang, J, Wang, Y, Frey, G, Abeles, R.H, Petsko, G.A, Ringe, D.
登録日2003-12-18
公開日2005-04-12
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Crystal structure of human myristoyl-CoA:protein N-myristoyltransferase
To be Published
7RK3
DownloadVisualize
BU of 7rk3 by Molmil
Crystal structure of human N-myristoyltransferase 1 fragment (residues 109-496) bound to diacylated human Arf6 octapeptide and Coenzyme A
分子名称: 4'-diphospho pantetheine, ADP-ribosylation factor 6, Glycylpeptide N-tetradecanoyltransferase 1, ...
著者Fenwick, M.K, Lin, H.
登録日2021-07-21
公開日2022-07-27
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Crystal structure of human N-myristoyltransferase 1 fragment (residues 109-496) bound to diacylated human Arf6 octapeptide and Coenzyme A
To Be Published
6B1L
DownloadVisualize
BU of 6b1l by Molmil
Crystal structure of glycylpeptide N-tetradecanoyltransferase from Plasmodium vivax in complex with inhibitor IMP-0001173
分子名称: 1-(5-fluoro-2-{methyl[3-(methylamino)propyl]amino}pyrimidin-4-yl)-N-[(imidazo[1,2-a]pyridin-3-yl)methyl]azetidine-3-carboxamide, Glycylpeptide N-tetradecanoyltransferase, TETRADECANOYL-COA
著者Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日2017-09-18
公開日2018-09-26
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal structure of glycylpeptide N-tetradecanoyltransferase from Plasmodium vivax in complex with inhibitor IMP-0001173
to be published
1NMT
DownloadVisualize
BU of 1nmt by Molmil
N-MYRISTOYL TRANSFERASE FROM CANDIDA ALBICANS AT 2.45 A
分子名称: GLYCEROL, N-MYRISTOYL TRANSFERASE
著者Weston, S.A, Pauptit, R.A.
登録日1997-12-11
公開日1999-01-13
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献Crystal structure of the anti-fungal target N-myristoyl transferase.
Nat.Struct.Biol., 5, 1998
2WUU
DownloadVisualize
BU of 2wuu by Molmil
Structure of N-myristoyltransferase from L. donovani
分子名称: 2-oxopentadecyl-CoA, N-MYRISTOYLTRANSFERASE
著者Brannigan, J.A, Smith, B.A, Yu, Z, Hodgkinson, M.R, Leatherbarrow, R.J, Tate, E.W, Brzozowski, A.M, Smith, D.F, Wilkinson, A.J.
登録日2009-10-09
公開日2009-12-01
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.42 Å)
主引用文献N-Myristoyltransferase from Leishmania Donovani: Structural and Functional Characterisation of a Potential Drug Target for Visceral Leishmaniasis.
J.Mol.Biol., 396, 2010
2WSA
DownloadVisualize
BU of 2wsa by Molmil
Crystal Structure of Leishmania major N-myristoyltransferase (NMT) with bound myristoyl-CoA and a pyrazole sulphonamide ligand (DDD85646)
分子名称: 2,6-dichloro-4-(2-piperazin-1-ylpyridin-4-yl)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide, GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, TETRADECANOYL-COA
著者Robinson, D.A, Brand, S, Fairlamb, A.H, Ferguson, M.A.J, Frearson, J.A, Wyatt, P.G, Structural Genomics Consortium (SGC)
登録日2009-09-04
公開日2010-03-23
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献N-Myristoyltransferase Inhibitors as New Leads to Treat Sleeping Sickness.
Nature, 464, 2010
2YND
DownloadVisualize
BU of 2ynd by Molmil
Plasmodium vivax N-myristoyltransferase in complex with a pyrazole sulphonamide inhibitor.
分子名称: 2,6-dichloro-4-(2-piperazin-1-ylpyridin-4-yl)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide, 2-oxopentadecyl-CoA, CHLORIDE ION, ...
著者Wright, M.H, Clough, B, Rackham, M.D, Brannigan, J.A, Grainger, M, Bottrill, A.R, Heal, W.P, Broncel, M, Serwa, R.A, Mann, D, Leatherbarrow, R.J, Wilkinson, A.J, Holder, A.A, Tate, E.W.
登録日2012-10-13
公開日2014-01-15
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.89 Å)
主引用文献Validation of N-Myristoyltransferase as an Antimalarial Drug Target Using an Integrated Chemical Biology Approach.
Nat.Chem., 6, 2014
2YNE
DownloadVisualize
BU of 2yne by Molmil
Plasmodium vivax N-myristoyltransferase in complex with a benzothiophene inhibitor
分子名称: 2-(3-piperidin-4-yloxy-1-benzothiophen-2-yl)-5-[(1,3,5-trimethylpyrazol-4-yl)methyl]-1,3,4-oxadiazole, 2-oxopentadecyl-CoA, CHLORIDE ION, ...
著者Wright, M.H, Clough, B, Rackham, M.D, Brannigan, J.A, Grainger, M, Bottrill, A.R, Heal, W.P, Broncel, M, Serwa, R.A, Mann, D, Leatherbarrow, R.J, Wilkinson, A.J, Holder, A.A, Tate, E.W.
登録日2012-10-13
公開日2014-01-15
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.72 Å)
主引用文献Validation of N-Myristoyltransferase as an Antimalarial Drug Target Using an Integrated Chemical Biology Approach.
Nat.Chem., 6, 2014
5UUT
DownloadVisualize
BU of 5uut by Molmil
N-myristoyltransferase 1 (NMT) bound to myristoyl-CoA
分子名称: CITRIC ACID, Glycylpeptide N-tetradecanoyltransferase 1, TETRADECANOYL-COA
著者Goodwin, O, Pegan, S.
登録日2017-02-17
公開日2018-01-17
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.252 Å)
主引用文献Blocking Myristoylation of Src Inhibits Its Kinase Activity and Suppresses Prostate Cancer Progression.
Cancer Res., 77, 2017
5V0X
DownloadVisualize
BU of 5v0x by Molmil
Crystal structure of glycylpeptide N-tetradecanoyltransferase from Plasmodium vivax in complex with inhibitor IMP-0001114
分子名称: CHLORIDE ION, Glycylpeptide N-tetradecanoyltransferase, SULFATE ION, ...
著者Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日2017-02-28
公開日2018-03-07
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystal structure of glycylpeptide N-tetradecanoyltransferase from Plasmodium vivax in complex with inhibitor IMP-0001114
to be published
5V0W
DownloadVisualize
BU of 5v0w by Molmil
Crystal structure of glycylpeptide N-tetradecanoyltransferase from Plasmodium vivax in complex with inhibitor IMP-0001088
分子名称: 1-[5-[3,4-bis(fluoranyl)-2-[2-(1,3,5-trimethylpyrazol-4-yl)ethoxy]phenyl]-1-methyl-indazol-3-yl]-~{N},~{N}-dimethyl-methanamine, CHLORIDE ION, Glycylpeptide N-tetradecanoyltransferase, ...
著者Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日2017-02-28
公開日2018-03-07
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Crystal structure of glycylpeptide N-tetradecanoyltransferase from Plasmodium vivax in complex with inhibitor IMP-0001088
to be published
2YNC
DownloadVisualize
BU of 2ync by Molmil
Plasmodium vivax N-myristoyltransferase in complex with YnC12-CoA thioester.
分子名称: CHLORIDE ION, DIMETHYL SULFOXIDE, GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, ...
著者Wright, M.H, Clough, B, Rackham, M.D, Brannigan, J.A, Grainger, M, Bottrill, A.R, Heal, W.P, Broncel, M, Serwa, R.A, Mann, D, Leatherbarrow, R.J, Wilkinson, A.J, Holder, A.A, Tate, E.W.
登録日2012-10-13
公開日2014-01-15
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Validation of N-Myristoyltransferase as an Antimalarial Drug Target Using an Integrated Chemical Biology Approach.
Nat.Chem., 6, 2014
5G21
DownloadVisualize
BU of 5g21 by Molmil
Leishmania major N-myristoyltransferase in complex with a quinoline inhibitor (compound 26).
分子名称: ETHYL 4-[(2-CYANOETHYL)SULFANYL]-6-{[6-(PIPERAZIN-1-YL), GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, MAGNESIUM ION, ...
著者Goncalves, V, Brannigan, J.A, Laporte, A, Bell, A.S, Roberts, S.M, Wilkinson, A.J, Leatherbarrow, R.J, Tate, E.W.
登録日2016-04-06
公開日2017-02-15
最終更新日2017-06-28
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Structure-guided optimization of quinoline inhibitors of Plasmodium N-myristoyltransferase.
Medchemcomm, 8, 2017
1IIC
DownloadVisualize
BU of 1iic by Molmil
Crystal Structure of Saccharomyces cerevisiae N-myristoyltransferase with Bound MyristoylCoA
分子名称: PEPTIDE N-myristoyltransferase, TETRADECANOYL-COA
著者Farazi, T.A, Waksman, G, Gordon, J.I.
登録日2001-04-22
公開日2001-05-02
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structures of Saccharomyces cerevisiae N-myristoyltransferase with bound myristoylCoA and peptide provide insights about substrate recognition and catalysis.
Biochemistry, 40, 2001
1IYK
DownloadVisualize
BU of 1iyk by Molmil
Crystal structure of candida albicans N-myristoyltransferase with myristoyl-COA and peptidic inhibitor
分子名称: MYRISTOYL-COA:PROTEIN N-MYRISTOYLTRANSFERASE, TETRADECANOYL-COA, [CYCLOHEXYLETHYL]-[[[[4-[2-METHYL-1-IMIDAZOLYL-BUTYL]PHENYL]ACETYL]-SERYL]-LYSINYL]-AMINE
著者Sogabe, S, Fukami, T.A, Morikami, K, Shiratori, Y, Aoki, Y, D'Arcy, A, Winkler, F.K, Banner, D.W, Ohtsuka, T.
登録日2002-08-29
公開日2002-12-30
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal Structures of Candida albicans N-Myristoyltransferase with Two Distinct Inhibitors
CHEM.BIOL., 9, 2002
1IYL
DownloadVisualize
BU of 1iyl by Molmil
Crystal Structure of Candida albicans N-myristoyltransferase with Non-peptidic Inhibitor
分子名称: (1-METHYL-1H-IMIDAZOL-2-YL)-(3-METHYL-4-{3-[(PYRIDIN-3-YLMETHYL)-AMINO]-PROPOXY}-BENZOFURAN-2-YL)-METHANONE, Myristoyl-CoA:Protein N-Myristoyltransferase
著者Sogabe, S, Fukami, T.A, Morikami, K, Shiratori, Y, Aoki, Y, D'Arcy, A, Winkler, F.K, Banner, D.W, Ohtsuka, T.
登録日2002-08-29
公開日2002-12-30
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Crystal Structures of Candida albicans N-Myristoyltransferase with Two Distinct Inhibitors
CHEM.BIOL., 9, 2002
1IID
DownloadVisualize
BU of 1iid by Molmil
Crystal Structure of Saccharomyces cerevisiae N-myristoyltransferase with Bound S-(2-oxo)pentadecylCoA and the Octapeptide GLYASKLA
分子名称: NICKEL (II) ION, Octapeptide GLYASKLA, Peptide N-myristoyltransferase, ...
著者Farazi, T.A, Gordon, J.I, Waksman, G.
登録日2001-04-22
公開日2001-05-02
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structures of Saccharomyces cerevisiae N-myristoyltransferase with bound myristoylCoA and peptide provide insights about substrate recognition and catalysis.
Biochemistry, 40, 2001
6TW5
DownloadVisualize
BU of 6tw5 by Molmil
Plasmodium vivax N-myristoyltransferase with bound indazole inhibitor IMP-917
分子名称: 1-[5-[4-fluoranyl-2-[2-(1,3,5-trimethylpyrazol-4-yl)ethoxy]phenyl]-2~{H}-indazol-3-yl]-~{N},~{N}-dimethyl-methanamine, CHLORIDE ION, DIMETHYL SULFOXIDE, ...
著者Brannigan, J.A.
登録日2020-01-12
公開日2021-07-21
最終更新日2024-05-15
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Plasmodium vivax N-myristoyltransferase with bound indazole inhibitor IMP-917
To Be Published
6TW6
DownloadVisualize
BU of 6tw6 by Molmil
Plasmodium vivax N-myristoyltransferase with bound indazole inhibitor IMP-923
分子名称: 2-oxopentadecyl-CoA, CHLORIDE ION, DIMETHYL SULFOXIDE, ...
著者Brannigan, J.A.
登録日2020-01-12
公開日2021-07-21
最終更新日2024-05-15
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Plasmodium vivax N-myristoyltransferase with bound indazole inhibitor IMP-923
To Be Published
6TW7
DownloadVisualize
BU of 6tw7 by Molmil
Leishmania major N-myristoyltransferase in complex with indazole inhibitor IMP-918
分子名称: Glycylpeptide N-tetradecanoyltransferase, MAGNESIUM ION, TETRADECANOYL-COA, ...
著者Brannigan, J.A.
登録日2020-01-12
公開日2021-07-21
最終更新日2024-05-15
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Leishmania major N-myristoyltransferase in complex with indazole inhibitor IMP-918
To Be Published
6TW8
DownloadVisualize
BU of 6tw8 by Molmil
Leishmania major N-myristoyltransferase in complex with indazole inhibitor IMP-917
分子名称: 1-[5-[4-fluoranyl-2-[2-(1,3,5-trimethylpyrazol-4-yl)ethoxy]phenyl]-2~{H}-indazol-3-yl]-~{N},~{N}-dimethyl-methanamine, Glycylpeptide N-tetradecanoyltransferase, MAGNESIUM ION, ...
著者Brannigan, J.A.
登録日2020-01-12
公開日2021-07-21
最終更新日2024-05-15
実験手法X-RAY DIFFRACTION (1.79 Å)
主引用文献Leishmania major N-myristoyltransferase in complex with indazole inhibitor IMP-917
To Be Published
2NMT
DownloadVisualize
BU of 2nmt by Molmil
MYRISTOYL-COA:PROTEIN N-MYRISTOYLTRANSFERASE BOUND TO MYRISTOYL-COA AND PEPTIDE ANALOGS
分子名称: GLYCEROL, MYRISTOYL-COA:PROTEIN N-MYRISTOYLTRANSFERASE, S-(2-OXO)PENTADECYLCOA, ...
著者Fuetterer, K, Bhatnagar, R.S, Waksman, G.
登録日1998-07-14
公開日1999-01-06
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Structure of N-myristoyltransferase with bound myristoylCoA and peptide substrate analogs.
Nat.Struct.Biol., 5, 1998
5G20
DownloadVisualize
BU of 5g20 by Molmil
Leishmania major N-myristoyltransferase in complex with a quinoline inhibitor (compound 19).
分子名称: 6-(BENZYLOXY)-4-(ETHYLSULFANYL)-3-[(MORPHOLIN-4-YL), DIMETHYL SULFOXIDE, GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, ...
著者Goncalves, V, Brannigan, J.A, Laporte, A, Bell, A.S, Roberts, S.M, Wilkinson, A.J, Leatherbarrow, R.J, Tate, E.W.
登録日2016-04-06
公開日2017-02-15
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.52 Å)
主引用文献Structure-guided optimization of quinoline inhibitors of Plasmodium N-myristoyltransferase.
Medchemcomm, 8, 2017

221051

件を2024-06-12に公開中

PDB statisticsPDBj update infoContact PDBjnumon