6MB0
Crystal structure of N-myristoyl transferase (NMT) G386E mutant from Plasmodium vivax in complex with inhibitor IMP-1002
Summary for 6MB0
Entry DOI | 10.2210/pdb6mb0/pdb |
Descriptor | Glycylpeptide N-tetradecanoyltransferase, TETRADEC-13-YNOIC ACID - COA THIOESTER, 1-(5-{4-fluoro-2-[2-(1,3,5-trimethyl-1H-pyrazol-4-yl)ethoxy]phenyl}-1-methyl-1H-indazol-3-yl)-N,N-dimethylmethanamine, ... (7 entities in total) |
Functional Keywords | ssgcid, glycylpeptide n-tetradecanoyltransferase, n-myristoyltransferase, nmt, salvador i, structural genomics, seattle structural genomics center for infectious disease, transferase |
Biological source | Plasmodium vivax |
Total number of polymer chains | 3 |
Total formula weight | 146619.83 |
Authors | Seattle Structural Genomics Center for Infectious Disease (SSGCID) (deposition date: 2018-08-29, release date: 2019-06-05, Last modification date: 2024-03-13) |
Primary citation | Schlott, A.C.,Mayclin, S.,Reers, A.R.,Coburn-Flynn, O.,Bell, A.S.,Green, J.,Knuepfer, E.,Charter, D.,Bonnert, R.,Campo, B.,Burrows, J.,Lyons-Abbott, S.,Staker, B.L.,Chung, C.W.,Myler, P.J.,Fidock, D.A.,Tate, E.W.,Holder, A.A. Structure-Guided Identification of Resistance Breaking Antimalarial N‐Myristoyltransferase Inhibitors. Cell Chem Biol, 26:991-, 2019 Cited by PubMed: 31080074DOI: 10.1016/j.chembiol.2019.03.015 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.55 Å) |
Structure validation
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