6MB0
Crystal structure of N-myristoyl transferase (NMT) G386E mutant from Plasmodium vivax in complex with inhibitor IMP-1002
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C | Glycylpeptide N-tetradecanoyltransferase | polymer | 405 | 47323.0 | 3 | UniProt (A0A1G4HIY1) Pfam (PF01233) Pfam (PF02799) In PDB | Plasmodium vivax | |
2 | A, B, C | TETRADEC-13-YNOIC ACID - COA THIOESTER | non-polymer | 973.9 | 3 | Chemie (YNC) | |||
3 | A, B, C | 1-(5-{4-fluoro-2-[2-(1,3,5-trimethyl-1H-pyrazol-4-yl)ethoxy]phenyl}-1-methyl-1H-indazol-3-yl)-N,N-dimethylmethanamine | non-polymer | 435.5 | 3 | Chemie (JCY) | |||
4 | A, B | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
5 | A, B, C | CHLORIDE ION | non-polymer | 35.5 | 3 | Chemie (CL) | |||
6 | B, C | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
7 | water | water | 18.0 | 1807 | Chemie (HOH) |
Sequence modifications
A, B, C: 27 - 410 (UniProt: A0A1G4HIY1)
PDB | External Database | Details |
---|---|---|
Met 6 | - | expression tag |
Gly 7 | - | expression tag |
Ser 8 | - | expression tag |
Ser 9 | - | expression tag |
His 10 | - | expression tag |
His 11 | - | expression tag |
His 12 | - | expression tag |
His 13 | - | expression tag |
His 14 | - | expression tag |
His 15 | - | expression tag |
Ser 16 | - | expression tag |
Ala 17 | - | expression tag |
Ala 18 | - | expression tag |
Leu 19 | - | expression tag |
Glu 20 | - | expression tag |
Val 21 | - | expression tag |
Leu 22 | - | expression tag |
Phe 23 | - | expression tag |
Gln 24 | - | expression tag |
Gly 25 | - | expression tag |
Pro 26 | - | expression tag |
Glu 386 | Gly 386 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 141969.0 | |
Non-Polymers* | Number of molecules | 13 |
Total formula weight | 4650.8 | |
All* | Total formula weight | 146619.8 |