2YND

Plasmodium vivax N-myristoyltransferase in complex with a pyrazole sulphonamide inhibitor.

Summary for 2YND

Entry DOI	10.2210/pdb2ynd/pdb
Related	2YNC 2YNE 4A95 4B10 4B11 4B12 4B13 4B14 4BBH
Descriptor	GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, DIMETHYL SULFOXIDE, 2-oxopentadecyl-CoA, ... (8 entities in total)
Functional Keywords	transferase, myristoylation, malaria, pyrazole sulphonamide
Biological source	PLASMODIUM VIVAX
Total number of polymer chains	3
Total formula weight	140150.44
Authors	Wright, M.H.,Clough, B.,Rackham, M.D.,Brannigan, J.A.,Grainger, M.,Bottrill, A.R.,Heal, W.P.,Broncel, M.,Serwa, R.A.,Mann, D.,Leatherbarrow, R.J.,Wilkinson, A.J.,Holder, A.A.,Tate, E.W. (deposition date: 2012-10-13, release date: 2014-01-15, Last modification date: 2014-02-05)
Primary citation	Wright, M.H.,Clough, B.,Rackham, M.D.,Rangachari, K.,Brannigan, J.A.,Grainger, M.,Moss, D.K.,Bottrill, A.R.,Heal, W.P.,Broncel, M.,Serwa, R.A.,Brady, D.,Mann, D.,Leatherbarrow, R.J.,Tewari, R.,Wilkinson, A.J.,Holder, A.A.,Tate, E.W. Validation of N-Myristoyltransferase as an Antimalarial Drug Target Using an Integrated Chemical Biology Approach. Nat.Chem., 6:112-, 2014 Cited by PubMed: 24451586 DOI: 10.1038/NCHEM.1836 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.89 Å)

Structure validation