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2WSA

Crystal Structure of Leishmania major N-myristoyltransferase (NMT) with bound myristoyl-CoA and a pyrazole sulphonamide ligand (DDD85646)

Summary for 2WSA
Entry DOI10.2210/pdb2wsa/pdb
DescriptorGLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, TETRADECANOYL-COA, 2,6-dichloro-4-(2-piperazin-1-ylpyridin-4-yl)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide, ... (4 entities in total)
Functional Keywordsacyltransferase, transferase, drug discovery
Biological sourceLEISHMANIA MAJOR
Total number of polymer chains1
Total formula weight52000.55
Authors
Robinson, D.A.,Brand, S.,Fairlamb, A.H.,Ferguson, M.A.J.,Frearson, J.A.,Wyatt, P.G.,Structural Genomics Consortium (SGC) (deposition date: 2009-09-04, release date: 2010-03-23, Last modification date: 2023-12-20)
Primary citationFrearson, J.A.,Brand, S.,Cleghorn, L.A.T.,Mcelroy, S.,Smid, O.,Stojanovski, L.,Torrie, L.,Robinson, D.A.,Hallyburton, I.,Guther, M.L.,Price, H.P.,Mpamhanga, C.P.,Brannigan, J.A.,Hodgkinson, M.,Raimi, O.,Van Aalten, D.M.F.,Brenk, R.,Gilbert, I.H.,Read, K.D.,Fairlamb, A.H.,Ferguson, M.A.J.,Smith, D.F.,Wyatt, P.G.
N-Myristoyltransferase Inhibitors as New Leads to Treat Sleeping Sickness.
Nature, 464:728-, 2010
Cited by
PubMed: 20360736
DOI: 10.1038/NATURE08893
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.6 Å)
Structure validation

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