2WSA
Crystal Structure of Leishmania major N-myristoyltransferase (NMT) with bound myristoyl-CoA and a pyrazole sulphonamide ligand (DDD85646)
Summary for 2WSA
Entry DOI | 10.2210/pdb2wsa/pdb |
Descriptor | GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, TETRADECANOYL-COA, 2,6-dichloro-4-(2-piperazin-1-ylpyridin-4-yl)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide, ... (4 entities in total) |
Functional Keywords | acyltransferase, transferase, drug discovery |
Biological source | LEISHMANIA MAJOR |
Total number of polymer chains | 1 |
Total formula weight | 52000.55 |
Authors | Robinson, D.A.,Brand, S.,Fairlamb, A.H.,Ferguson, M.A.J.,Frearson, J.A.,Wyatt, P.G.,Structural Genomics Consortium (SGC) (deposition date: 2009-09-04, release date: 2010-03-23, Last modification date: 2023-12-20) |
Primary citation | Frearson, J.A.,Brand, S.,Cleghorn, L.A.T.,Mcelroy, S.,Smid, O.,Stojanovski, L.,Torrie, L.,Robinson, D.A.,Hallyburton, I.,Guther, M.L.,Price, H.P.,Mpamhanga, C.P.,Brannigan, J.A.,Hodgkinson, M.,Raimi, O.,Van Aalten, D.M.F.,Brenk, R.,Gilbert, I.H.,Read, K.D.,Fairlamb, A.H.,Ferguson, M.A.J.,Smith, D.F.,Wyatt, P.G. N-Myristoyltransferase Inhibitors as New Leads to Treat Sleeping Sickness. Nature, 464:728-, 2010 Cited by PubMed: 20360736DOI: 10.1038/NATURE08893 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
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