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3H5Z

Crystal Structure of Leishmania major N-myristoyltransferase with bound myristoyl-CoA

Summary for 3H5Z
Entry DOI10.2210/pdb3h5z/pdb
DescriptorGlycylpeptide N-tetradecanoyltransferase, TETRADECANOYL-COA, 1,2-ETHANEDIOL, ... (5 entities in total)
Functional Keywordstransferase, n-myristoyltransferase, nmt, leishmania major, structural genomics, structural genomics consortium, sgc, acyltransferase
Biological sourceLeishmania major
Total number of polymer chains1
Total formula weight51553.21
Authors
Primary citationFrearson, J.A.,Brand, S.,McElroy, S.P.,Cleghorn, L.A.,Smid, O.,Stojanovski, L.,Price, H.P.,Guther, M.L.,Torrie, L.S.,Robinson, D.A.,Hallyburton, I.,Mpamhanga, C.P.,Brannigan, J.A.,Wilkinson, A.J.,Hodgkinson, M.,Hui, R.,Qiu, W.,Raimi, O.G.,van Aalten, D.M.,Brenk, R.,Gilbert, I.H.,Read, K.D.,Fairlamb, A.H.,Ferguson, M.A.,Smith, D.F.,Wyatt, P.G.
N-myristoyltransferase inhibitors as new leads to treat sleeping sickness.
Nature, 464:728-732, 2010
Cited by
PubMed: 20360736
DOI: 10.1038/nature08893
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.49 Å)
Structure validation

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