3H5Z
Crystal Structure of Leishmania major N-myristoyltransferase with bound myristoyl-CoA
Summary for 3H5Z
Entry DOI | 10.2210/pdb3h5z/pdb |
Descriptor | Glycylpeptide N-tetradecanoyltransferase, TETRADECANOYL-COA, 1,2-ETHANEDIOL, ... (5 entities in total) |
Functional Keywords | transferase, n-myristoyltransferase, nmt, leishmania major, structural genomics, structural genomics consortium, sgc, acyltransferase |
Biological source | Leishmania major |
Total number of polymer chains | 1 |
Total formula weight | 51553.21 |
Authors | Qiu, W.,Hutchinson, A.,Lin, Y.-H.,Wernimont, A.,Mackenzie, F.,Ravichandran, M.,Cossar, D.,Zhao, Y.,Schapira, M.,Arrowsmith, C.H.,Bountra, C.,Weigelt, J.,Edwards, A.M.,Ferguson, M.A.J.,Fairlamb, A.H.,Hui, R.,Structural Genomics Consortium (SGC) (deposition date: 2009-04-22, release date: 2009-05-12, Last modification date: 2023-09-06) |
Primary citation | Frearson, J.A.,Brand, S.,McElroy, S.P.,Cleghorn, L.A.,Smid, O.,Stojanovski, L.,Price, H.P.,Guther, M.L.,Torrie, L.S.,Robinson, D.A.,Hallyburton, I.,Mpamhanga, C.P.,Brannigan, J.A.,Wilkinson, A.J.,Hodgkinson, M.,Hui, R.,Qiu, W.,Raimi, O.G.,van Aalten, D.M.,Brenk, R.,Gilbert, I.H.,Read, K.D.,Fairlamb, A.H.,Ferguson, M.A.,Smith, D.F.,Wyatt, P.G. N-myristoyltransferase inhibitors as new leads to treat sleeping sickness. Nature, 464:728-732, 2010 Cited by PubMed: 20360736DOI: 10.1038/nature08893 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.49 Å) |
Structure validation
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