6NXG

Crystal structure of glycylpeptide N-tetradecanoyltransferase from Plasmodium vivax in complex with inhibitor 303a

Summary for 6NXG

Entry DOI	10.2210/pdb6nxg/pdb
Descriptor	Glycylpeptide N-tetradecanoyltransferase, MAGNESIUM ION, CHLORIDE ION, ... (9 entities in total)
Functional Keywords	transferase, structural genomics, seattle structural genomics center for infectious disease, ssgcid, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Plasmodium vivax (strain Salvador I)
Total number of polymer chains	3
Total formula weight	146099.08
Authors	Staker, B.L.,Mayclin, S.,Seattle Structural Genomics Center for Infectious Disease (SSGCID) (deposition date: 2019-02-08, release date: 2020-01-01, Last modification date: 2023-10-11)
Primary citation	Harupa, A.,De Las Heras, L.,Colmenarejo, G.,Lyons-Abbott, S.,Reers, A.,Caballero Hernandez, I.,Chung, C.W.,Charter, D.,Myler, P.J.,Fernandez-Menendez, R.M.,Calderon, F.,Palomo, S.,Rodriguez, B.,Berlanga, M.,Herreros-Aviles, E.,Staker, B.L.,Fernandez Alvaro, E.,Kaushansky, A. Identification of Selective Inhibitors ofPlasmodiumN-Myristoyltransferase by High-Throughput Screening. J.Med.Chem., 63:591-600, 2020 Cited by PubMed: 31850752 DOI: 10.1021/acs.jmedchem.9b01343 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation