5AGE
CRYSTAL STRUCTURE OF LEISHMANIA MAJOR N-MYRISTOYLTRANSFERASE (NMT) WITH BOUND MYRISTOYL-COA AND A BENZOMORPHOLINONE LIGAND
Summary for 5AGE
Entry DOI | 10.2210/pdb5age/pdb |
Related | 5AG4 5AG5 5AG6 5AG7 |
Descriptor | GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, 4-[(5-methyl-1,2-oxazol-3-yl)methyl]-7-[4-(1-methylpiperidin-4-yl)butyl]-2H-1,4-benzoxazin-3(4H)-one, TETRADECANOYL-COA, ... (4 entities in total) |
Functional Keywords | nmt, acyltransferase, transferase, drug discovery |
Biological source | LEISHMANIA MAJOR |
Total number of polymer chains | 1 |
Total formula weight | 51888.65 |
Authors | Robinson, D.A.,Spinks, D.,Smith, V.C.,Thompson, S.,Smith, A.,Torrie, L.S.,McElroy, S.P.,Brand, S.,Brenk, R.,Frearson, J.A.,Read, K.D.,Wyatt, P.G.,Gilbert, I.H. (deposition date: 2015-01-29, release date: 2015-10-07, Last modification date: 2024-01-10) |
Primary citation | Spinks, D.,Smith, V.,Thompson, S.,Robinson, D.A.,Luksch, T.,Smith, A.,Torrie, L.S.,Mcelroy, S.,Stojanovski, L.,Norval, S.,Collie, I.T.,Hallyburton, I.,Rao, B.,Brand, S.,Brenk, R.,Frearson, J.A.,Read, K.D.,Wyatt, P.G.,Gilbert, I.H. Development of Small-Molecule Trypanosoma Brucei N-Myristoyltransferase Inhibitors: Discovery and Optimisation of a Novel Binding Mode. Chemmedchem, 10:1821-, 2015 Cited by PubMed: 26395087DOI: 10.1002/CMDC.201500301 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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