4W9D
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![BU of 4w9d by Molmil](/molmil-images/mine/4w9d) | pVHL:EloB:EloC in complex with (2S,4R)-1-(3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methyloxazol-5-yl)benzyl)pyrrolidine-2-carboxamide (ligand 3) | 分子名称: | (4R)-1-(3,3-dimethylbutanoyl)-4-hydroxy-N-[4-(4-methyl-1,3-oxazol-5-yl)benzyl]-L-prolinamide, Transcription elongation factor B polypeptide 1, Transcription elongation factor B polypeptide 2, ... | 著者 | Gadd, M.S, Hewitt, S, Galdeano, C, van Molle, I, Ciulli, A. | 登録日 | 2014-08-27 | 公開日 | 2014-09-10 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structure-Guided Design and Optimization of Small Molecules Targeting the Protein-Protein Interaction between the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar Affinities. J.Med.Chem., 57, 2014
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4M0W
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![BU of 4m0w by Molmil](/molmil-images/mine/4m0w) | Crystal Structure of SARS-CoV papain-like protease C112S mutant in complex with ubiquitin | 分子名称: | 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, GLYCEROL, Replicase polyprotein 1a, ... | 著者 | Chou, C.-Y, Chen, H.-Y, Lai, H.-Y, Cheng, S.-C, Chou, Y.-W. | 登録日 | 2013-08-02 | 公開日 | 2014-02-12 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Structural basis for catalysis and ubiquitin recognition by the severe acute respiratory syndrome coronavirus papain-like protease Acta Crystallogr.,Sect.D, 70, 2014
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2RR9
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![BU of 2rr9 by Molmil](/molmil-images/mine/2rr9) | The solution structure of the K63-Ub2:tUIMs complex | 分子名称: | Putative uncharacterized protein UIMC1, ubiquitin | 著者 | Sekiyama, N, Jee, J, Isogai, S, Akagi, K, Huang, T, Ariyoshi, M, Tochio, H, Shirakawa, M. | 登録日 | 2010-06-16 | 公開日 | 2011-07-06 | 最終更新日 | 2011-07-13 | 実験手法 | SOLUTION NMR | 主引用文献 | The solution structure of the K63-Ub2:tUIMs complex To be Published
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4NNJ
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4PYU
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![BU of 4pyu by Molmil](/molmil-images/mine/4pyu) | The conserved ubiquitin-like protein hub1 plays a critical role in splicing in human cells | 分子名称: | U4/U6.U5 tri-snRNP-associated protein 1, Ubiquitin-like protein 5 | 著者 | Ammon, T, Mishra, S.K, Kowalska, K, Popowicz, G.M, Holak, T.A, Jentsch, S. | 登録日 | 2014-03-28 | 公開日 | 2014-07-16 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | The conserved ubiquitin-like protein Hub1 plays a critical role in splicing in human cells. J Mol Cell Biol, 6, 2014
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4LCD
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![BU of 4lcd by Molmil](/molmil-images/mine/4lcd) | |
4MSQ
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![BU of 4msq by Molmil](/molmil-images/mine/4msq) | Crystal structure of Schizosaccharomyces pombe AMSH-like protease sst2 catalytic domain bound to ubiquitin | 分子名称: | 1,2-ETHANEDIOL, AMSH-like protease sst2, PHOSPHATE ION, ... | 著者 | Shrestha, R.K, Ronau, J.A, Das, C. | 登録日 | 2013-09-18 | 公開日 | 2014-06-18 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.952 Å) | 主引用文献 | Insights into the Mechanism of Deubiquitination by JAMM Deubiquitinases from Cocrystal Structures of the Enzyme with the Substrate and Product. Biochemistry, 53, 2014
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2WDT
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![BU of 2wdt by Molmil](/molmil-images/mine/2wdt) | Crystal structure of Plasmodium falciparum UCHL3 in complex with the suicide inhibitor UbVME | 分子名称: | CHLORIDE ION, UBIQUITIN, UBIQUITIN CARBOXYL-TERMINAL HYDROLASE L3 | 著者 | Weihofen, W.A, Artavanis-Tsakonas, K, Gaudet, R, Ploegh, H.L. | 登録日 | 2009-03-26 | 公開日 | 2009-12-29 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Characterization and Structural Studies of the Plasmodium Falciparum Ubiquitin and Nedd8 Hydrolase Uchl3. J.Biol.Chem., 285, 2010
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4P4H
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4LJP
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![BU of 4ljp by Molmil](/molmil-images/mine/4ljp) | Structure of an active ligase (HOIP-H889A)/ubiquitin transfer complex | 分子名称: | E3 ubiquitin-protein ligase RNF31, Polyubiquitin-C, ZINC ION | 著者 | Rana, R.R, Stieglitz, B, Koliopoulos, M.G, Morris-Davies, A.C, Christodoulou, E, Howell, S, Brown, N.R, Rittinger, K. | 登録日 | 2013-07-05 | 公開日 | 2013-10-16 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Structural basis for ligase-specific conjugation of linear ubiquitin chains by HOIP. Nature, 503, 2013
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4S1Z
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![BU of 4s1z by Molmil](/molmil-images/mine/4s1z) | Crystal structure of TRABID NZF1 in complex with K29 linked di-Ubiquitin | 分子名称: | Ubiquitin, Ubiquitin thioesterase ZRANB1, ZINC ION | 著者 | Kristariyanto, Y.A, Abdul Rehman, S.A, Campbell, D.G, Morrice, N.A, Johnson, C, Toth, R, Kulathu, Y. | 登録日 | 2015-01-16 | 公開日 | 2015-04-08 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (3.03 Å) | 主引用文献 | K29-selective ubiquitin binding domain reveals structural basis of specificity and heterotypic nature of k29 polyubiquitin. Mol.Cell, 58, 2015
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2XBB
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![BU of 2xbb by Molmil](/molmil-images/mine/2xbb) | Nedd4 HECT:Ub complex | 分子名称: | E3 UBIQUITIN-PROTEIN LIGASE NEDD4, GLYCEROL, UBIQUITIN | 著者 | Maspero, E, Cecatiello, V, Musacchio, A, Polo, S, Pasqualato, S. | 登録日 | 2010-04-08 | 公開日 | 2011-03-23 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.68 Å) | 主引用文献 | Structure of the Hect:Ubiquitin Complex and its Role in Ubiquitin Chain Elongation Embo Rep., 12, 2011
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4NQK
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![BU of 4nqk by Molmil](/molmil-images/mine/4nqk) | Structure of an Ubiquitin complex | 分子名称: | Probable ATP-dependent RNA helicase DDX58, Ubiquitin | 著者 | Peisley, A, Wu, B, Hur, S. | 登録日 | 2013-11-25 | 公開日 | 2014-03-05 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (3.7 Å) | 主引用文献 | Structural basis for ubiquitin-mediated antiviral signal activation by RIG-I. Nature, 509, 2014
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4MSM
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![BU of 4msm by Molmil](/molmil-images/mine/4msm) | Crystal structure of Schizosaccharomyces pombe AMSH-like protease sst2 E286A mutant bound to ubiquitin | 分子名称: | 1,2-ETHANEDIOL, AMSH-like protease sst2, PHOSPHATE ION, ... | 著者 | Shrestha, R.K, Ronau, J.A, Das, C. | 登録日 | 2013-09-18 | 公開日 | 2014-06-18 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.74 Å) | 主引用文献 | Insights into the Mechanism of Deubiquitination by JAMM Deubiquitinases from Cocrystal Structures of the Enzyme with the Substrate and Product. Biochemistry, 53, 2014
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2Y5B
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![BU of 2y5b by Molmil](/molmil-images/mine/2y5b) | Structure of USP21 in complex with linear diubiquitin-aldehyde | 分子名称: | SULFATE ION, UBIQUITIN, UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 21, ... | 著者 | Ye, Y, Akutsu, M, Reyes-Turcu, F, Enchev, R.I, Wilkinson, K.D, Komander, D. | 登録日 | 2011-01-12 | 公開日 | 2012-01-25 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Polyubiquitin Binding and Cross-Reactivity in the Usp Domain Deubiquitinase Usp21. Embo Rep., 12, 2011
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4N9F
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![BU of 4n9f by Molmil](/molmil-images/mine/4n9f) | Crystal structure of the Vif-CBFbeta-CUL5-ElOB-ElOC pentameric complex | 分子名称: | Core-binding factor subunit beta, Cullin-5, Transcription elongation factor B polypeptide 1, ... | 著者 | Guo, Y.Y, Dong, L.Y, Huang, Z.W. | 登録日 | 2013-10-21 | 公開日 | 2014-01-08 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | Structural basis for hijacking CBF-b and CUL5 E3 ligase complex by HIV-1 Vif Nature, 505, 2014
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4RF0
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![BU of 4rf0 by Molmil](/molmil-images/mine/4rf0) | Crystal structure of the Middle-East respiratory syndrome coronavirus papain-like protease in complex with ubiquitin (space group P6522) | 分子名称: | 3-AMINOPROPANE, ORF1ab protein, SULFATE ION, ... | 著者 | Bailey-Elkin, B.A, Johnson, G.G, Mark, B.L. | 登録日 | 2014-09-24 | 公開日 | 2014-10-22 | 最終更新日 | 2015-01-14 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Crystal Structure of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Papain-like Protease Bound to Ubiquitin Facilitates Targeted Disruption of Deubiquitinating Activity to Demonstrate Its Role in Innate Immune Suppression. J.Biol.Chem., 289, 2014
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4NQL
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![BU of 4nql by Molmil](/molmil-images/mine/4nql) | The crystal structure of the DUB domain of AMSH orthologue, Sst2 from S. pombe, in complex with lysine 63-linked diubiquitin | 分子名称: | 1,2-ETHANEDIOL, AMSH-like protease sst2, Ubiquitin, ... | 著者 | Ronau, J.A, Shrestha, R.K, Das, C. | 登録日 | 2013-11-25 | 公開日 | 2014-10-08 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Insights into the mechanism of deubiquitination by JAMM deubiquitinases from cocrystal structures of the enzyme with the substrate and product. Biochemistry, 53, 2014
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4RF1
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![BU of 4rf1 by Molmil](/molmil-images/mine/4rf1) | Crystal structure of the Middle-East respiratory syndrome coronavirus papain-like protease in complex with ubiquitin (space group P63) | 分子名称: | 3-AMINOPROPANE, ORF1ab protein, S-1,2-PROPANEDIOL, ... | 著者 | Bailey-Elkin, B.A, Johnson, G.G, Mark, B.L. | 登録日 | 2014-09-24 | 公開日 | 2014-10-22 | 最終更新日 | 2015-01-14 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Crystal Structure of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Papain-like Protease Bound to Ubiquitin Facilitates Targeted Disruption of Deubiquitinating Activity to Demonstrate Its Role in Innate Immune Suppression. J.Biol.Chem., 289, 2014
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4MM3
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4BOZ
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![BU of 4boz by Molmil](/molmil-images/mine/4boz) | Structure of OTUD2 OTU domain in complex with K11-linked di ubiquitin | 分子名称: | GLYCEROL, UBIQUITIN THIOESTERASE OTU1, UBIQUITIN-C | 著者 | Mevissen, T.E.T, Hospenthal, M.K, Geurink, P.P, Elliott, P.R, Akutsu, M, Arnaudo, N, Ekkebus, R, Kulathu, Y, Wauer, T, El Oualid, F, Freund, S.M.V, Ovaa, H, Komander, D. | 登録日 | 2013-05-22 | 公開日 | 2013-07-17 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (3.03 Å) | 主引用文献 | Otu Deubiquitinases Reveal Mechanisms of Linkage Specificity and Enable Ubiquitin Chain Restriction Analysis. Cell(Cambridge,Mass.), 154, 2013
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3DQV
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![BU of 3dqv by Molmil](/molmil-images/mine/3dqv) | Structural Insights into NEDD8 Activation of Cullin-RING Ligases: Conformational Control of Conjugation | 分子名称: | Cullin-5, NEDD8, Rbx1, ... | 著者 | Duda, D.M, Borg, L.A, Scott, D.C, Hunt, H.W, Hammel, M, Schulman, B.A. | 登録日 | 2008-07-09 | 公開日 | 2008-09-30 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugation. Cell(Cambridge,Mass.), 134, 2008
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3DVN
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3DBH
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3DBR
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![BU of 3dbr by Molmil](/molmil-images/mine/3dbr) | |