4N9F

Crystal structure of the Vif-CBFbeta-CUL5-ElOB-ElOC pentameric complex

Summary for 4N9F

DescriptorCullin-5, Transcription elongation factor B polypeptide 1, Transcription elongation factor B polypeptide 2, ... (6 entities in total)
Functional Keywordszinc finger motif, stabilize vif interaction with cul5, cul5, transcription-viral protein complex, ligase-viral protein complex, ligase/viral protein
Biological sourceHomo sapiens (human)
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Cellular locationNucleus (Probable) Q15369 Q15370
Nucleus (Potential) Q13951
Host cytoplasm Q72499
Total number of polymer chains60
Total molecular weight1200461.93
Authors
Guo, Y.Y.,Dong, L.Y.,Huang, Z.W. (deposition date: 2013-10-21, release date: 2014-01-08)
Primary citation
Guo, Y.Y.,Dong, L.Y.,Qiu, X.L.,Wang, Y.S.,Zhang, B.L.,Liu, H.N.,Yu, Y.,Zang, Y.,Yang, M.J.,Huang, Z.W.
Structural basis for hijacking CBF-b and CUL5 E3 ligase complex by HIV-1 Vif
Nature, 505:229-233, 2014
Experimental method
X-RAY DIFFRACTION (3.3 Å)
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Structure validation

RfreeRamachandran outliersSidechain outliersRSRZ outliers 0.325 0.3% 22.5% 13.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
171588
PDB entries from 2020-11-25