4N9F

Crystal structure of the Vif-CBFbeta-CUL5-ElOB-ElOC pentameric complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, DB, EA, F, JA... (U, C, I, O, V...)	Cullin-5	polymer	311	36386.8	12	UniProt (Q93034) Pfam (PF00888)	Homo sapiens (human)	CUL-5, Vasopressin-activated calcium-mobilizing receptor 1, VACM-1
2	AA, B, EB, FA, G... (Y, E, K, Q, Z...)	Transcription elongation factor B polypeptide 1	polymer	96	10843.4	12	UniProt (Q15369) Pfam (PF03931)	Homo sapiens (human)	Elongin 15 kDa subunit, Elongin-C, EloC, RNA polymerase II transcription factor SIII subunit C, SIII p15
3	AB, BA, C, FB, GA... (X, D, J, P, W...)	Transcription elongation factor B polypeptide 2	polymer	102	11488.0	12	UniProt (Q15370) Pfam (PF00240)	Homo sapiens (human)	Elongin 18 kDa subunit, Elongin-B, EloB, RNA polymerase II transcription factor SIII subunit B, SIII p18
4	BB, CA, D, GB, HA... (a, F, L, R, c...)	Core-binding factor subunit beta	polymer	170	20272.6	12	UniProt (Q13951) Pfam (PF02312)	Homo sapiens (human)	CBF-beta, Polyomavirus enhancer-binding protein 2 beta subunit, PEA2-beta, PEBP2-beta, SL3-3 enhancer factor 1 subunit beta, SL3/AKV core-binding factor beta subunit
5	CB, DA, E, HB, IA... (b, G, M, S, d...)	Virion infectivity factor	polymer	176	20982.2	12	UniProt (Q72499) Pfam (PF00559) UniProt (by SIFTS) (P12504)	Human immunodeficiency virus 1
6	IB, JB, KB, LB, MB... (b, G, M, S, d...)	ZINC ION	non-polymer		65.4	12	Chemie (ZN)

Sequence modifications

U, C, I, O, V, f, l, r, x, 3, 9, w: 12 - 321 (UniProt: Q93034)

PDB	External Database	Details
Ala 11	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	60
	Total formula weight	1199677.0
Non-Polymers*	Number of molecules	12
	Total formula weight	784.9
All*	Total formula weight	1200461.9

*Water molecules are not included.