4MM3

Crystal structure of SARS-CoV papain-like protease PLpro in complex with ubiquitin aldehyde

Summary for 4MM3

Related2FE8 1UBQ
DescriptorUbiquitin, Papain-like proteinase, ZINC ION, ... (4 entities in total)
Functional Keywordsnsp3 papain-like protease domain, signaling protein-hydrolase complex, signaling protein/hydrolase
Biological sourceHomo sapiens (human)
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Cellular locationUbiquitin: Cytoplasm  P0CG48
Non-structural protein 3: Host membrane ; Multi-pass membrane protein . Non-structural protein 4: Host membrane ; Multi-pass membrane protein . Non-structural protein 6: Host membrane ; Multi-pass membrane protein . Non-structural protein 7: Host cytoplasm, host perinuclear region . Non-structural protein 8: Host cytoplasm, host perinuclear region . Non-structural protein 9: Host cytoplasm, host perinuclear region . Non-structural protein 10: Host cytoplasm, host perinuclear region  P0C6U8
Total number of polymer chains2
Total molecular weight44146.51
Authors
Mesecar, A.D.,Ratia, K. (deposition date: 2013-09-08, release date: 2014-07-02, Last modification date: 2017-11-15)
Primary citation
Ratia, K.,Kilianski, A.,Baez-Santos, Y.M.,Baker, S.C.,Mesecar, A.
Structural Basis for the Ubiquitin-Linkage Specificity and deISGylating activity of SARS-CoV papain-like protease.
Plos Pathog., 10:e1004113-e1004113, 2014
PubMed: 24854014 (PDB entries with the same primary citation)
DOI: 10.1371/journal.ppat.1004113
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.752 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.28261.0%3.8%9.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report