4M0W

Crystal Structure of SARS-CoV papain-like protease C112S mutant in complex with ubiquitin

Summary for 4M0W

DescriptorReplicase polyprotein 1a, Ubiquitin, ZINC ION, ... (7 entities in total)
Functional Keywordspapain-like protease-ubiquitin complex, protein hydrolase and deubiquitination, hydrolase-protein binding complex, hydrolase/protein binding
Biological sourceSARS coronavirus (SARS-CoV)
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Cellular locationNon-structural protein 3: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 4: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 6: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 7: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 8: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 9: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 10: Host cytoplasm, host perinuclear region (By similarity) P0C6U8
Ubiquitin: Cytoplasm (By similarity) P62992
Total number of polymer chains2
Total molecular weight46214.76
Authors
Chou, C.-Y.,Chen, H.-Y.,Lai, H.-Y.,Cheng, S.-C.,Chou, Y.-W. (deposition date: 2013-08-02, release date: 2014-02-12, Last modification date: 2014-04-30)
Primary citation
Chou, C.-Y.,Lai, H.-Y.,Chen, H.-Y.,Cheng, S.-C.,Cheng, K.-W.,Chou, Y.-W.
Structural basis for catalysis and ubiquitin recognition by the severe acute respiratory syndrome coronavirus papain-like protease
Acta Crystallogr.,Sect.D, 70:572-581, 2014
PubMed: 24531491 (PDB entries with the same primary citation)
DOI: 10.1107/S1399004713031040
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.4 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.17840.3%0.9%3.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report