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PDB: 145 件
7U5P
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CRYSTAL STRUCTURE OF THE ACTIVIN RECEPTOR TYPE-2A LIGAND BINDING DOMAIN IN COMPLEX WITH ACTIVIN-A
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Activin receptor type-2A, Inhibin beta A chain
著者Chu, K.Y, Malik, A, Thamilselvan, V, Martinez-Hackert, E.
登録日2022-03-02
公開日2022-06-22
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.14 Å)
主引用文献Type II BMP and activin receptors BMPR2 and ACVR2A share a conserved mode of growth factor recognition.
J.Biol.Chem., 298, 2022
4YCG
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Pro-bone morphogenetic protein 9
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Bone Morphogenetic Protein 9 Growth Factor Domain, Bone Morphogenetic Protein 9 Prodomain, ...
著者Mi, L.-Z, Brown, C.T, Gao, Y, Tian, Y, Le, V, Walz, T, Springer, T.A.
登録日2015-02-20
公開日2015-03-04
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Structure of bone morphogenetic protein 9 procomplex.
Proc.Natl.Acad.Sci.USA, 112, 2015
4YCI
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non-latent pro-bone morphogenetic protein 9
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Bone Morphogenetic Protein 9 Growth Factor Domain, ...
著者Mi, L.Z, Brown, C.T, Gao, Y, Tian, Y, Le, V, Walz, T, Springer, T.A.
登録日2015-02-20
公開日2015-03-04
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3.25 Å)
主引用文献Structure of bone morphogenetic protein 9 procomplex.
Proc.Natl.Acad.Sci.USA, 112, 2015
3RJR
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BU of 3rjr by Molmil
Crystal Structure of pro-TGF beta 1
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Transforming growth factor beta-1
著者Zhu, J.H, Shi, M.L, Springer, T.A.
登録日2011-04-15
公開日2011-06-15
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (3.05 Å)
主引用文献Latent TGF-Beta structure and activation
Nature, 474, 2011
3HH2
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BU of 3hh2 by Molmil
Crystal structure of the myostatin:follistatin 288 complex
分子名称: CITRIC ACID, Follistatin, Growth/differentiation factor 8, ...
著者Cash, J.N, Thompson, T.B.
登録日2009-05-14
公開日2009-08-04
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献The structure of myostatin:follistatin 288: insights into receptor utilization and heparin binding
Embo J., 28, 2009
5NTU
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Crystal Structure of human Pro-myostatin Precursor at 2.6 A Resolution
分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, Growth/differentiation factor 8
著者Cotton, T.R, Fischer, G, Hyvonen, M.
登録日2017-04-28
公開日2018-01-17
最終更新日2018-02-21
実験手法X-RAY DIFFRACTION (2.58 Å)
主引用文献Structure of the human myostatin precursor and determinants of growth factor latency.
EMBO J., 37, 2018
5NXS
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Crystal Structure of Human Pro-myostatin Precursor at 4.2 A Resolution with Experimental Phases from SeMet labelling
分子名称: Growth/differentiation factor 8
著者Cotton, T.R, Fischer, G, Hyvonen, M.
登録日2017-05-10
公開日2018-01-17
最終更新日2018-02-21
実験手法X-RAY DIFFRACTION (4.19 Å)
主引用文献Structure of the human myostatin precursor and determinants of growth factor latency.
EMBO J., 37, 2018
6GFF
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Structure of GARP (LRRC32) in complex with latent TGF-beta1 and MHG-8 Fab
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Leucine-rich repeat-containing protein 32, MHG-8 Fab heavy chain, ...
著者Merceron, R, Lienart, S, Vanderaa, C, Colau, D, Stockis, J, Van Der Woning, B, De Haard, H, Saunders, M, Coulie, P.G, Savvides, S.N, Lucas, S.
登録日2018-04-30
公開日2018-11-07
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Structural basis of latent TGF-beta 1 presentation and activation by GARP on human regulatory T cells.
Science, 362, 2018
6GL7
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Neurturin-GFRa2-RET extracellular complex
分子名称: GDNF family receptor alpha-2, Neurturin, Proto-oncogene tyrosine-protein kinase receptor Ret
著者Bigalke, J.M, Aibara, S, Sandmark, J, Amunts, A.
登録日2018-05-23
公開日2019-08-14
最終更新日2019-12-18
実験手法ELECTRON MICROSCOPY (6.3 Å)
主引用文献Cryo-EM structure of the activated RET signaling complex reveals the importance of its cysteine-rich domain.
Sci Adv, 5, 2019
7Y1T
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Complex of integrin alphaV/beta8 and L-TGF-beta1 at a ratio of 1:2
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Duan, Z, Zhang, Z.
登録日2022-06-08
公開日2022-08-31
最終更新日2022-09-07
実験手法ELECTRON MICROSCOPY (3.24 Å)
主引用文献Specificity of TGF-beta 1 signal designated by LRRC33 and integrin alpha V beta 8.
Nat Commun, 13, 2022
7Y1R
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Human L-TGF-beta1 in complex with the anchor protein LRRC33
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Duan, Z, Zhang, Z.
登録日2022-06-08
公開日2022-08-31
最終更新日2022-09-07
実験手法ELECTRON MICROSCOPY (4.01 Å)
主引用文献Specificity of TGF-beta 1 signal designated by LRRC33 and integrin alpha V beta 8.
Nat Commun, 13, 2022
5MR4
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Ligand-receptor complex.
分子名称: DI(HYDROXYETHYL)ETHER, FORMIC ACID, GDNF family receptor alpha-2, ...
著者Sandmark, J, Oster, L, Aagaard, A, Roth, R.G, Dahl, G.
登録日2016-12-21
公開日2018-01-17
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structure and biophysical characterization of the human full-length neurturin-GFRa2 complex: A role for heparan sulfate in signaling.
J. Biol. Chem., 293, 2018
5MR5
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BU of 5mr5 by Molmil
Ligand-receptor complex.
分子名称: GDNF family receptor alpha-2, GLYCEROL, Neurturin, ...
著者Sandmark, J, Oster, L, Aagaard, A, Roth, R, Dahl, G.
登録日2016-12-21
公開日2018-01-17
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structure and biophysical characterization of the human full-length neurturin-GFRa2 complex: A role for heparan sulfate in signaling.
J. Biol. Chem., 293, 2018
1ES7
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BU of 1es7 by Molmil
COMPLEX BETWEEN BMP-2 AND TWO BMP RECEPTOR IA ECTODOMAINS
分子名称: BONE MORPHOGENETIC PROTEIN RECEPTOR IA, BONE MORPHOGENETIC PROTEIN-2
著者Kirsch, T, Sebald, W, Dreyer, M.K.
登録日2000-04-07
公開日2000-10-07
最終更新日2018-04-04
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Crystal structure of the BMP-2-BRIA ectodomain complex.
Nat.Struct.Biol., 7, 2000
5FFO
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BU of 5ffo by Molmil
Integrin alpha V beta 6 in complex with pro-TGF-beta
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
著者Dong, X, Zhao, B, Springer, T.A.
登録日2015-12-18
公開日2017-01-25
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (3.49 Å)
主引用文献Force interacts with macromolecular structure in activation of TGF-beta.
Nature, 542, 2017
8C7H
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BU of 8c7h by Molmil
Cryo-EM Map of the latTGF-beta 28G11 Fab complex
分子名称: 28G11 Fab heavy chain, 28G11 Fab light chain, Transforming growth factor beta activator LRRC32, ...
著者Ebenhoch, R, Nar, H.
登録日2023-01-16
公開日2023-03-01
最終更新日2023-03-29
実験手法ELECTRON MICROSCOPY (2.7 Å)
主引用文献Anti-GARP Antibodies Inhibit Release of TGF-beta by Regulatory T Cells via Different Modes of Action, but Do Not Influence Their Function In Vitro.
Immunohorizons, 7, 2023
3B4V
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BU of 3b4v by Molmil
X-Ray structure of Activin in complex with FSTL3
分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, Inhibin beta A chain, ...
著者Thompson, T.B.
登録日2007-10-24
公開日2008-09-02
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.48 Å)
主引用文献The structure of FSTL3.activin A complex. Differential binding of N-terminal domains influences follistatin-type antagonist specificity.
J.Biol.Chem., 283, 2008
3EO1
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BU of 3eo1 by Molmil
Structure of the Fab Fragment of GC-1008 in Complex with Transforming Growth Factor-Beta 3
分子名称: GC-1008 Fab Heavy Chain, GC-1008 Fab Light Chain, Transforming growth factor beta-3
著者Gruetter, C, Gruetter, M.G.
登録日2008-09-26
公開日2008-12-02
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献A cytokine-neutralizing antibody as a structural mimetic of 2 receptor interactions
Proc.Natl.Acad.Sci.Usa, 105, 2008
5VQF
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BU of 5vqf by Molmil
Crystal Structure of pro-TGF-beta 1
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Transforming growth factor beta-1, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
著者Zhao, B, Xu, S, Dong, X, Lu, C, Springer, T.A.
登録日2017-05-08
公開日2017-11-15
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Prodomain-growth factor swapping in the structure of pro-TGF-beta 1.
J. Biol. Chem., 293, 2018
5VZ4
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Receptor-growth factor crystal structure at 2.20 Angstrom resolution
分子名称: 1,2-ETHANEDIOL, BROMIDE ION, GDNF family receptor alpha-like, ...
著者Lakshminarasimhan, D, White, A, Suto, R.K.
登録日2017-05-26
公開日2017-09-27
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15.
Nature, 550, 2017
5VQP
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Crystal structure of human pro-TGF-beta1
分子名称: Transforming growth factor beta-1, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
著者Zhao, B, Xu, S, Dong, X, Lu, C, Springer, T.A.
登録日2017-05-09
公開日2017-11-15
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Prodomain-growth factor swapping in the structure of pro-TGF-beta 1.
J. Biol. Chem., 293, 2018
1NYS
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BU of 1nys by Molmil
Crystal Structure of Activin A Bound to the ECD of ActRIIB P41
分子名称: Inhibin beta A chain, activin receptor
著者Thompson, T.B, Woodruff, T.K, Jardetzky, T.S.
登録日2003-02-13
公開日2003-04-08
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (3.05 Å)
主引用文献Structures of an ActRIIB:activin A complex reveal a novel binding mode for TGF-beta ligand:receptor interactions
EMBO J., 22, 2003
4UI1
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BU of 4ui1 by Molmil
Crystal structure of the human RGMC-BMP2 complex
分子名称: 1,2-ETHANEDIOL, BONE MORPHOGENETIC PROTEIN 2, CHLORIDE ION, ...
著者Healey, E.G, Bishop, B, Elegheert, J, Bell, C.H, Padilla-Parra, S, Siebold, C.
登録日2015-03-27
公開日2015-05-06
最終更新日2015-06-17
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Repulsive Guidance Molecule is a Structural Bridge between Neogenin and Bone Morphogenetic Protein.
Nat.Struct.Mol.Biol., 22, 2015
4UHY
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Crystal structure of the human RGMA-BMP2 complex
分子名称: BONE MORPHOGENETIC PROTEIN 2, REPULSIVE GUIDANCE MOLECULE A
著者Healey, E.G, Bishop, B, Elegheert, J, Bell, C.H, Padilla-Parra, S, Siebold, C.
登録日2015-03-27
公開日2015-05-06
最終更新日2015-06-17
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Repulsive Guidance Molecule is a Structural Bridge between Neogenin and Bone Morphogenetic Protein.
Nat.Struct.Mol.Biol., 22, 2015
4UHZ
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Crystal structure of the human RGMB-BMP2 complex, crystal form 1
分子名称: BONE MORPHOGENETIC PROTEIN 2, RGM DOMAIN FAMILY MEMBER B, SULFATE ION
著者Healey, E.G, Bishop, B, Elegheert, J, Bell, C.H, Padilla-Parra, S, Siebold, C.
登録日2015-03-27
公開日2015-05-06
最終更新日2015-06-17
実験手法X-RAY DIFFRACTION (2.85 Å)
主引用文献Repulsive Guidance Molecule is a Structural Bridge between Neogenin and Bone Morphogenetic Protein.
Nat.Struct.Mol.Biol., 22, 2015

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