7F4F
| Cryo-EM structure of afamelanotide-bound melanocortin-1 receptor in complex with Gs protein and scFv16 | 分子名称: | Afamelanotide, CALCIUM ION, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Ma, S, Chen, Y, Dai, A, Yin, W, Guo, J, Yang, D, Zhou, F, Jiang, Y, Wang, M.-W, Xu, H.E. | 登録日 | 2021-06-18 | 公開日 | 2021-09-08 | 最終更新日 | 2022-02-16 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structural mechanism of calcium-mediated hormone recognition and G beta interaction by the human melanocortin-1 receptor. Cell Res., 31, 2021
|
|
8WRB
| Lysophosphatidylserine receptor GPR34-Gi complex | 分子名称: | Antibody fragment scFv16, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Gong, W, Liu, G, Li, X, Wang, Y, Zhang, X. | 登録日 | 2023-10-13 | 公開日 | 2023-11-08 | 最終更新日 | 2023-12-20 | 実験手法 | ELECTRON MICROSCOPY (2.91 Å) | 主引用文献 | Structural basis for ligand recognition and signaling of the lysophosphatidylserine receptors GPR34 and GPR174. Plos Biol., 21, 2023
|
|
8J6I
| Cryo-EM structure of thehydroxycarboxylic acid receptor 2-Gi protein complex bound MK-6892 | 分子名称: | 2-[[2,2-dimethyl-3-[3-(5-oxidanylpyridin-2-yl)-1,2,4-oxadiazol-5-yl]propanoyl]amino]cyclohexene-1-carboxylic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Yuan, Q, Zhu, S, Duan, J, Xu, H.E, Duan, X. | 登録日 | 2023-04-26 | 公開日 | 2024-04-03 | 実験手法 | ELECTRON MICROSCOPY (2.92 Å) | 主引用文献 | Molecular recognition of niacin and lipid-lowering drugs by the human hydroxycarboxylic acid receptor 2. Cell Rep, 42, 2023
|
|
8IZ4
| Lysophosphatidylserine receptor GPR34-Gi complex | 分子名称: | Antibody fragment scFv16, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Gong, W, Liu, G, Li, X, Zhang, X. | 登録日 | 2023-04-06 | 公開日 | 2024-04-10 | 実験手法 | ELECTRON MICROSCOPY (2.93 Å) | 主引用文献 | Structural mechanisms of ligand binding and signaling in lysophosphatidylserine receptors To Be Published
|
|
8FYL
| Vilazodone-bound serotonin 1A (5-HT1A) receptor-Gi1 protein complex | 分子名称: | 5-{4-[4-(5-cyano-1H-indol-3-yl)butyl]piperazin-1-yl}-1-benzofuran-2-carboxamide, CHOLESTEROL HEMISUCCINATE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Warren, A.L, Zilberg, G, Capper, M.J, Wacker, D. | 登録日 | 2023-01-26 | 公開日 | 2024-05-15 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (2.94 Å) | 主引用文献 | Structural pharmacology and therapeutic potential of 5-methoxytryptamines. Nature, 630, 2024
|
|
8SG1
| Cryo-EM structure of CMKLR1 signaling complex | 分子名称: | CHOLESTEROL, Chemerin 9, Chemerin-like receptor 1, ... | 著者 | Zhang, X, Zhang, C. | 登録日 | 2023-04-11 | 公開日 | 2023-11-01 | 最終更新日 | 2023-12-20 | 実験手法 | ELECTRON MICROSCOPY (2.94 Å) | 主引用文献 | Structural basis of G protein-Coupled receptor CMKLR1 activation and signaling induced by a chemerin-derived agonist. Plos Biol., 21, 2023
|
|
8HNM
| CXCR3-DNGi complex activated by VUF11222 | 分子名称: | CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Jiao, H.Z, Hu, H.L. | 登録日 | 2022-12-08 | 公開日 | 2023-11-29 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (2.94 Å) | 主引用文献 | Structural insights into the activation and inhibition of CXC chemokine receptor 3. Nat.Struct.Mol.Biol., 31, 2024
|
|
8HQM
| Activation mechanism of GPR132 by NPGLY | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | 著者 | Wang, J.L, Ding, J.H, Sun, J.P, Yu, X. | 登録日 | 2022-12-13 | 公開日 | 2023-10-11 | 最終更新日 | 2023-11-01 | 実験手法 | ELECTRON MICROSCOPY (2.95 Å) | 主引用文献 | Functional screening and rational design of compounds targeting GPR132 to treat diabetes. Nat Metab, 5, 2023
|
|
7YON
| Complex structure of Neuropeptide Y Y2 receptor in complex with PYY(3-36) and Gi | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | 著者 | Kang, H, Park, C, Kim, J, Choi, H.-J. | 登録日 | 2022-08-01 | 公開日 | 2023-03-22 | 実験手法 | ELECTRON MICROSCOPY (2.95 Å) | 主引用文献 | Structural basis for Y2 receptor-mediated neuropeptide Y and peptide YY signaling. Structure, 31, 2023
|
|
8KFX
| Gi bound CCR8 complex with nonpeptide agonist LMD-009 | 分子名称: | 8-[[3-(2-methoxyphenoxy)phenyl]methyl]-1-(2-phenylethyl)-1,3,8-triazaspiro[4.5]decan-4-one, C-C chemokine receptor type 8,Fusion protein, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Jiang, S, Lin, X, Wu, L.J, Xu, F. | 登録日 | 2023-08-16 | 公開日 | 2024-02-07 | 最終更新日 | 2024-02-14 | 実験手法 | ELECTRON MICROSCOPY (2.96 Å) | 主引用文献 | Unveiling the structural mechanisms of nonpeptide ligand recognition and activation in human chemokine receptor CCR8. Sci Adv, 10, 2024
|
|
7WYB
| ADGRL3/Gi complex | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | 著者 | He, Y, Qian, Y. | 登録日 | 2022-02-15 | 公開日 | 2022-10-26 | 最終更新日 | 2022-11-30 | 実験手法 | ELECTRON MICROSCOPY (2.97 Å) | 主引用文献 | Structural insights into adhesion GPCR ADGRL3 activation and G q , G s , G i , and G 12 coupling. Mol.Cell, 82, 2022
|
|
7VV3
| |
8HQE
| Cryo-EM structure of the apo-GPR132-Gi | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | 著者 | Wang, J.L, Ding, J.H, Sun, J.P, Yu, X. | 登録日 | 2022-12-13 | 公開日 | 2023-10-11 | 最終更新日 | 2023-11-01 | 実験手法 | ELECTRON MICROSCOPY (2.97 Å) | 主引用文献 | Functional screening and rational design of compounds targeting GPR132 to treat diabetes. Nat Metab, 5, 2023
|
|
8IW7
| Cryo-EM structure of the PEA-bound mTAAR9-Gs complex | 分子名称: | 2-PHENYLETHYLAMINE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Sun, J.P, Li, Q, Yang, F, Xu, Y.F, Guo, L.L, Lian, S, Zhang, M.H, Rong, N.K. | 登録日 | 2023-03-29 | 公開日 | 2023-05-31 | 最終更新日 | 2023-06-14 | 実験手法 | ELECTRON MICROSCOPY (2.97 Å) | 主引用文献 | Structural basis of amine odorant perception by a mammal olfactory receptor. Nature, 618, 2023
|
|
8GUS
| Cryo-EM structure of HU-CB2-G protein complex | 分子名称: | Cannabinoid receptor 2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Wu, L.J, Hua, T, Liu, Z.J, Li, X.T, Chang, H. | 登録日 | 2022-09-13 | 公開日 | 2023-05-10 | 実験手法 | ELECTRON MICROSCOPY (2.97 Å) | 主引用文献 | Structural basis of selective cannabinoid CB 2 receptor activation. Nat Commun, 14, 2023
|
|
8IHF
| Cryo-EM structure of HCA2-Gi complex with MK6892 | 分子名称: | 2-[[2,2-dimethyl-3-[3-(5-oxidanylpyridin-2-yl)-1,2,4-oxadiazol-5-yl]propanoyl]amino]cyclohexene-1-carboxylic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Suzuki, S, Nishikawa, K, Suzuki, H, Fujiyoshi, Y. | 登録日 | 2023-02-22 | 公開日 | 2023-08-30 | 最終更新日 | 2023-12-06 | 実験手法 | ELECTRON MICROSCOPY (2.97 Å) | 主引用文献 | Structural basis of hydroxycarboxylic acid receptor signaling mechanisms through ligand binding. Nat Commun, 14, 2023
|
|
7XAU
| Structure of somatostatin receptor 2 bound with octreotide. | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | 著者 | Bo, Q, Yang, F, Li, Y.G, Meng, X.Y, Zhang, H.H, Zhou, Y.X, Ling, S.L, Sun, D.M, Lv, P, Liu, L, Shi, P, Tian, C.L. | 登録日 | 2022-03-19 | 公開日 | 2022-08-31 | 実験手法 | ELECTRON MICROSCOPY (2.97 Å) | 主引用文献 | Structural insights into the activation of somatostatin receptor 2 by cyclic SST analogues. Cell Discov, 8, 2022
|
|
8JIM
| Cryo-EM structure of MMF bound ketone body receptor HCAR2-Gi signaling complex | 分子名称: | (2Z)-4-methoxy-4-oxobut-2-enoic acid, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Zhao, C, Tian, X.W, Liu, Y, Cheng, L, Yan, W, Shao, Z.H. | 登録日 | 2023-05-26 | 公開日 | 2023-09-06 | 最終更新日 | 2023-09-27 | 実験手法 | ELECTRON MICROSCOPY (2.98 Å) | 主引用文献 | Biased allosteric activation of ketone body receptor HCAR2 suppresses inflammation. Mol.Cell, 83, 2023
|
|
8GUT
| Cryo-EM structure of LEI-CB2-Gi complex | 分子名称: | 1-[[4-[5-fluoranyl-6-[(oxan-4-ylamino)methyl]pyridin-2-yl]phenyl]methyl]-3-(2-methylpropyl)imidazolidine-2,4-dione, Cannabinoid receptor 2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Liu, Z.J, Hua, T, Li, X.T, Chang, H, Wu, L.J. | 登録日 | 2022-09-13 | 公開日 | 2023-05-10 | 最終更新日 | 2023-05-24 | 実験手法 | ELECTRON MICROSCOPY (2.98 Å) | 主引用文献 | Structural basis of selective cannabinoid CB 2 receptor activation. Nat Commun, 14, 2023
|
|
7VDM
| |
7VIH
| Cryo-EM structure of Gi coupled Sphingosine 1-phosphate receptor bound with CBP-307 | 分子名称: | 1-[[2-fluoranyl-4-[5-[4-(2-methylpropyl)phenyl]-1,2,4-oxadiazol-3-yl]phenyl]methyl]azetidine-3-carboxylic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Yu, L.Y, Gan, B, Xiao, Q.J, Ren, R.B. | 登録日 | 2021-09-26 | 公開日 | 2022-09-28 | 最終更新日 | 2022-10-05 | 実験手法 | ELECTRON MICROSCOPY (2.98 Å) | 主引用文献 | Structural insights into sphingosine-1-phosphate receptor activation. Proc.Natl.Acad.Sci.USA, 119, 2022
|
|
8HNL
| CXCR3-DNGi complex activated by PS372424 | 分子名称: | (3S)-N-[(2S)-5-carbamimidamido-1-(cyclohexylmethylamino)-1-oxidanylidene-pentan-2-yl]-2-(4-oxidanylidene-4-phenyl-butanoyl)-3,4-dihydro-1H-isoquinoline-3-carboxamide, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Jiao, H.Z, Hu, H.L. | 登録日 | 2022-12-08 | 公開日 | 2023-11-29 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (2.98 Å) | 主引用文献 | Structural insights into the activation and inhibition of CXC chemokine receptor 3. Nat.Struct.Mol.Biol., 31, 2024
|
|
7EVY
| Cryo-EM structure of siponimod -bound Sphingosine-1-phosphate receptor 1 in complex with Gi protein | 分子名称: | 1-[[4-[(~{E})-~{N}-[[4-cyclohexyl-3-(trifluoromethyl)phenyl]methoxy]-~{C}-methyl-carbonimidoyl]-2-ethyl-phenyl]methyl]azetidine-3-carboxylic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Jia, G.W, Yuan, Y, Su, Z.M, Shao, Z.H. | 登録日 | 2021-05-24 | 公開日 | 2021-09-29 | 最終更新日 | 2022-02-16 | 実験手法 | ELECTRON MICROSCOPY (2.98 Å) | 主引用文献 | Structures of signaling complexes of lipid receptors S1PR1 and S1PR5 reveal mechanisms of activation and drug recognition. Cell Res., 31, 2021
|
|
8HBD
| Cryo-EM structure of IRL1620-bound ETBR-Gi complex | 分子名称: | Endothelin receptor type B,Endothelin receptor type B,Oplophorus-luciferin 2-monooxygenase catalytic subunit chimera, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Yuan, Q, Ji, Y, Jiang, Y, Duan, J, Xu, H.E. | 登録日 | 2022-10-28 | 公開日 | 2023-03-22 | 最終更新日 | 2023-10-04 | 実験手法 | ELECTRON MICROSCOPY (2.99 Å) | 主引用文献 | Structural basis of peptide recognition and activation of endothelin receptors. Nat Commun, 14, 2023
|
|
7WZ4
| Structure of an orphan GPCR-G protein signaling complex | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | 著者 | Xu, J, Chen, G, Liu, Z, Du, Y. | 登録日 | 2022-02-17 | 公開日 | 2022-10-26 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Activation and allosteric regulation of the orphan GPR88-Gi1 signaling complex. Nat Commun, 13, 2022
|
|