8JHC
 
 | | FZD3 in inactive state | | 分子名称: | Frizzled-3,Soluble cytochrome b562, anti-BRIL Fab Heavy chain, anti-BRIL Fab Light chain, ... | | 著者 | Xu, F, Zhang, Z. | | 登録日 | 2023-05-23 | | 公開日 | 2024-01-17 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | A framework for Frizzled-G protein coupling and implications to the PCP signaling pathways.
Cell Discov, 10, 2024
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5L7I
 | | Structure of human Smoothened in complex with Vismodegib | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-chloranyl-~{N}-(4-chloranyl-3-pyridin-2-yl-phenyl)-4-methylsulfonyl-benzamide, SODIUM ION, ... | | 著者 | Byrne, E.X.B, Sircar, R, Miller, P.S, Hedger, G, Luchetti, G, Nachtergaele, S, Tully, M.D, Mydock-McGrane, L, Covey, D.F, Rambo, R.F, Sansom, M.S.P, Newstead, S, Rohatgi, R, Siebold, C. | | 登録日 | 2016-06-03 | | 公開日 | 2016-07-20 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | | 主引用文献 | Structural basis of Smoothened regulation by its extracellular domains.
Nature, 535, 2016
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8GY7
 | | Cryo-EM structure of ACTH-bound melanocortin-2 receptor in complex with MRAP1 and Gs protein | | 分子名称: | CALCIUM ION, Corticotropin, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Luo, P, Feng, W.B, Ma, S.S, Dai, A.T, Yuan, Q.N, Wu, K, Yang, D.H, Wang, M.W, Xu, H.E, Jiang, Y. | | 登録日 | 2022-09-21 | | 公開日 | 2023-01-11 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Structural basis of signaling regulation of the human melanocortin-2 receptor by MRAP1.
Cell Res., 33, 2023
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6KO5
 | | Complex structure of Ghrelin receptor with Fab | | 分子名称: | 6-(4-bromanyl-2-fluoranyl-phenoxy)-2-methyl-3-[[(3~{S})-1-propan-2-ylpiperidin-3-yl]methyl]pyrido[3,2-d]pyrimidin-4-one, Chimera of Soluble cytochrome b562 and Growth hormone secretagogue receptor type 1, Fab7881 Heavy Chain, ... | | 著者 | Shiimura, Y, Horita, S, Asada, H, Hirata, K, Iwata, S, Kojima, M. | | 登録日 | 2019-08-08 | | 公開日 | 2020-08-12 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | | 主引用文献 | Structure of an antagonist-bound ghrelin receptor reveals possible ghrelin recognition mode.
Nat Commun, 11, 2020
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7TX6
 | | Cryo-EM structure of the human reduced folate carrier in complex with methotrexate | | 分子名称: | Digitonin, METHOTREXATE, Reduced folate transporter,Soluble cytochrome b562 | | 著者 | Wright, N.J, Fedor, J.G, Lee, S.-Y. | | 登録日 | 2022-02-07 | | 公開日 | 2022-09-21 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Methotrexate recognition by the human reduced folate carrier SLC19A1.
Nature, 609, 2022
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7YIT
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7VOD
 | | Crystal structure of 5-HT2AR in complex with cariprazine | | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 3-[4-[2-[4-[2,3-bis(chloranyl)phenyl]piperazin-1-yl]ethyl]cyclohexyl]-1,1-dimethyl-urea, 5-hydroxytryptamine receptor 2A,Soluble cytochrome b562, ... | | 著者 | Chen, Z, Fan, L, Wang, H, Yu, J, Lu, D, Qi, J, Nie, F, Luo, Z, Liu, Z, Cheng, J, Wang, S. | | 登録日 | 2021-10-13 | | 公開日 | 2021-12-22 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | | 主引用文献 | Structure-based design of a novel third-generation antipsychotic drug lead with potential antidepressant properties.
Nat.Neurosci., 25, 2022
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7XTB
 | | Serotonin 6 (5-HT6) receptor-Gs-Nb35 complex | | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | | 著者 | Huang, S, Xu, P, Shen, D.D, Simon, I.A, Mao, C, Tan, Y, Zhang, H, Harpsoe, K, Li, H, Zhang, Y, You, C, Yu, X, Jiang, Y, Zhang, Y, Gloriam, D.E, Xu, H.E. | | 登録日 | 2022-05-16 | | 公開日 | 2022-07-27 | | 最終更新日 | 2022-08-03 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | GPCRs steer G i and G s selectivity via TM5-TM6 switches as revealed by structures of serotonin receptors.
Mol.Cell, 82, 2022
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4L6R
 | | Structure of the class B human glucagon G protein coupled receptor | | 分子名称: | DI(HYDROXYETHYL)ETHER, Soluble cytochrome b562 and Glucagon receptor chimera | | 著者 | Siu, F.Y, He, M, de Graaf, C, Han, G.W, Yang, D, Zhang, Z, Zhou, C, Xu, Q, Wacker, D, Joseph, J.S, Liu, W, Lau, J, Cherezov, V, Katritch, V, Wang, M.W, Stevens, R.C, GPCR Network (GPCR) | | 登録日 | 2013-06-12 | | 公開日 | 2013-07-24 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | | 主引用文献 | Structure of the human glucagon class B G-protein-coupled receptor.
Nature, 499, 2013
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6ME9
 | | XFEL crystal structure of human melatonin receptor MT2 in complex with ramelteon | | 分子名称: | N-{2-[(8S)-1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-yl]ethyl}propanamide, Soluble cytochrome b562,Melatonin receptor type 1B,Rubredoxin, ZINC ION | | 著者 | Johansson, L.C, Stauch, B, McCorvy, J, Han, G.W, Patel, N, Batyuk, A, Gati, C, Li, C, Grandner, J, Hao, S, Olsen, R.H.J, Tribo, A.R, Zaare, S, Zhu, L, Zatsepin, N.A, Weierstall, U, Liu, W, Roth, B.L, Katritch, V, Cherezov, V. | | 登録日 | 2018-09-05 | | 公開日 | 2019-04-24 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | | 主引用文献 | XFEL structures of the human MT2melatonin receptor reveal the basis of subtype selectivity.
Nature, 569, 2019
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5N2S
 | | Crystal structure of stabilized A1 receptor in complex with PSB36 at 3.3A resolution | | 分子名称: | 1-butyl-3-(3-oxidanylpropyl)-8-[(1~{R},5~{S})-3-tricyclo[3.3.1.0^{3,7}]nonanyl]-7~{H}-purine-2,6-dione, SULFATE ION, Soluble cytochrome b562,Adenosine receptor A1 | | 著者 | Cheng, R.K.Y, Segala, E, Robertson, N, Deflorian, F, Dore, A.S, Errey, J.C, Fiez-Vandal, C, Marshall, F.H, Cooke, R.M. | | 登録日 | 2017-02-08 | | 公開日 | 2017-07-26 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (3.303 Å) | | 主引用文献 | Structures of Human A1 and A2A Adenosine Receptors with Xanthines Reveal Determinants of Selectivity.
Structure, 25, 2017
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8V8D
 | | Alpha7-nicotinic acetylcholine receptor time resolved bound to epibatidine and PNU-120596 asymmetric state 2 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | 著者 | Burke, S.M, Noviello, C.M, Hibbs, R.E. | | 登録日 | 2023-12-05 | | 公開日 | 2024-02-21 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON MICROSCOPY (3.31 Å) | | 主引用文献 | Structural mechanisms of alpha 7 nicotinic receptor allosteric modulation and activation.
Cell, 187, 2024
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8DJK
 | | HMGCR-UBIAD1 Complex State 2 | | 分子名称: | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, CHOLESTEROL HEMISUCCINATE, Digitonin, ... | | 著者 | Chen, H, Qi, X, Li, X. | | 登録日 | 2022-06-30 | | 公開日 | 2022-08-03 | | 実験手法 | ELECTRON MICROSCOPY (3.33 Å) | | 主引用文献 | Regulated degradation of HMG CoA reductase requires conformational changes in sterol-sensing domain.
Nat Commun, 13, 2022
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6WWZ
 | | Cryo-EM structure of the human chemokine receptor CCR6 in complex with CCL20 and a Go protein | | 分子名称: | C-C chemokine receptor type 6,C-C chemokine receptor type 6, C-C motif chemokine 20, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Wasilko, D.J, Johnson, Z.L, Ammirati, M, Han, S, Wu, H. | | 登録日 | 2020-05-09 | | 公開日 | 2020-06-24 | | 最終更新日 | 2020-07-01 | | 実験手法 | ELECTRON MICROSCOPY (3.34 Å) | | 主引用文献 | Structural basis for chemokine receptor CCR6 activation by the endogenous protein ligand CCL20.
Nat Commun, 11, 2020
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8UHB
 | | Cryo-EM Structure of the Ro5256390-bound hTA1-Gs heterotrimer signaling complex | | 分子名称: | (2R,4S)-4-[(2S)-2-phenylbutyl]-1,3-oxazolidin-2-amine, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Zilberg, G, Warren, A.L, Parpounas, A.K, Wacker, D. | | 登録日 | 2023-10-08 | | 公開日 | 2024-01-10 | | 最終更新日 | 2024-05-01 | | 実験手法 | ELECTRON MICROSCOPY (3.35 Å) | | 主引用文献 | Molecular basis of human trace amine-associated receptor 1 activation.
Nat Commun, 15, 2024
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6WHA
 | | HTR2A bound to 25-CN-NBOH in complex with a mini-Galpha-q protein, beta/gamma subunits and an active-state stabilizing single-chain variable fragment (scFv16) obtained by cryo-electron microscopy (cryoEM) | | 分子名称: | 4-(2-{[(2-hydroxyphenyl)methyl]amino}ethyl)-2,5-dimethoxybenzonitrile, G subunit q (Gi2-mini-Gq chimeric), Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Skiniotis, G, Roth, B, Kim, K, Panova, O. | | 登録日 | 2020-04-07 | | 公開日 | 2020-09-23 | | 実験手法 | ELECTRON MICROSCOPY (3.36 Å) | | 主引用文献 | Structure of a Hallucinogen-Activated Gq-Coupled 5-HT2A Serotonin Receptor
Cell(Cambridge,Mass.), 182, 2020
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8JMT
 | | Structure of the adhesion GPCR ADGRL3 in the apo state | | 分子名称: | Adhesion G protein-coupled receptor L3,Soluble cytochrome b562 | | 著者 | Tao, Y, Guo, Q, He, B, Zhong, Y. | | 登録日 | 2023-06-05 | | 公開日 | 2023-09-06 | | 最終更新日 | 2024-07-10 | | 実験手法 | ELECTRON MICROSCOPY (3.36 Å) | | 主引用文献 | A method for structure determination of GPCRs in various states.
Nat.Chem.Biol., 20, 2024
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8I7W
 | | Cryo-EM structure of GSK256073 bound human hydroxy-carboxylic acid receptor 2 in complex with Gi heterotrimer | | 分子名称: | 8-chloranyl-3-pentyl-7H-purine-2,6-dione, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Park, J.H, Ishimoto, N, Park, S.Y. | | 登録日 | 2023-02-02 | | 公開日 | 2024-02-07 | | 実験手法 | ELECTRON MICROSCOPY (3.39 Å) | | 主引用文献 | Structural basis for ligand recognition and signaling of hydroxy-carboxylic acid receptor 2.
Nat Commun, 14, 2023
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7EXD
 | | Lasmiditan-bound serotonin 1F (5-HT1F) receptor-Gi protein complex | | 分子名称: | 2,4,6-tris(fluoranyl)-N-[6-(1-methylpiperidin-4-yl)carbonylpyridin-2-yl]benzamide, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Huang, S, Xu, P, Jiang, Y, Xu, H.E. | | 登録日 | 2021-05-27 | | 公開日 | 2021-08-04 | | 最終更新日 | 2021-10-06 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Structural basis for recognition of anti-migraine drug lasmiditan by the serotonin receptor 5-HT 1F -G protein complex.
Cell Res., 31, 2021
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6WH4
 | | Crystal structure of HTR2A with inverse agonist | | 分子名称: | 1-methyl-4-[(5~{S})-3-methylsulfanyl-5,6-dihydrobenzo[b][1]benzothiepin-5-yl]piperazine, 5-hydroxytryptamine receptor 2A,Soluble cytochrome b562 fusion, CHOLESTEROL, ... | | 著者 | Kim, K.L, Che, T, Krumm, B.E, Roth, B.L. | | 登録日 | 2020-04-07 | | 公開日 | 2020-09-23 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | | 主引用文献 | Structure of a Hallucinogen-Activated Gq-Coupled 5-HT 2A Serotonin Receptor
Cell(Cambridge,Mass.), 182, 2020
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7T32
 | | CryoEM structure of the adenosine 2A receptor-BRIL/Anti BRIL Fab complex with ZM241385 | | 分子名称: | 4-{2-[(7-amino-2-furan-2-yl[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino]ethyl}phenol, Adenosine receptor A2a/Soluble cytochrome b562 Fusion Protein | | 著者 | Zhang, K.H, Wu, H, Hoppe, N, Manglik, A, Cheng, Y.F. | | 登録日 | 2021-12-06 | | 公開日 | 2022-08-10 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Fusion protein strategies for cryo-EM study of G protein-coupled receptors.
Nat Commun, 13, 2022
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7C6A
 | | Crystal structure of AT2R-BRIL and SRP2070_Fab complex | | 分子名称: | IgG Light Chain, IgG heavy chain, SAR1, ... | | 著者 | Suzuki, M, Miyagi, H, Asada, H, Yasunaga, M, Suno, C, Takahashi, Y, Saito, J, Iwata, S. | | 登録日 | 2020-05-21 | | 公開日 | 2020-07-29 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | | 主引用文献 | The discovery of a new antibody for BRIL-fused GPCR structure determination.
Sci Rep, 10, 2020
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8JJO
 | | Cryo-EM structure of the beta2AR-mBRIL/1b3 Fab/Glue complex with an antagonist | | 分子名称: | (2S)-1-[(1-methylethyl)amino]-3-(2-prop-2-en-1-ylphenoxy)propan-2-ol, Beta-2 adrenergic receptor,Beta-2 adrenergic receptor,Soluble cytochrome b562 | | 著者 | He, B.B, Zhong, Y.X, Guo, Q, Tao, Y.Y. | | 登録日 | 2023-05-31 | | 公開日 | 2023-09-06 | | 最終更新日 | 2024-01-03 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | A method for structure determination of GPCRs in various states.
Nat.Chem.Biol., 20, 2024
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8J9O
 | | Cryo-EM structure of inactive FZD1 | | 分子名称: | Frizzled-1,Soluble cytochrome b562, anti-BRIL Fab Heavy Chain, anti-BRIL Fab Light Chain, ... | | 著者 | Lin, X, Xu, F. | | 登録日 | 2023-05-04 | | 公開日 | 2024-01-17 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | A framework for Frizzled-G protein coupling and implications to the PCP signaling pathways.
Cell Discov, 10, 2024
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8X64
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