6ME9
XFEL crystal structure of human melatonin receptor MT2 in complex with ramelteon
Summary for 6ME9
Entry DOI | 10.2210/pdb6me9/pdb |
Descriptor | Soluble cytochrome b562,Melatonin receptor type 1B,Rubredoxin, N-{2-[(8S)-1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-yl]ethyl}propanamide, ZINC ION (3 entities in total) |
Functional Keywords | gpcr, melatonin receptor type 1b (mt2), membrane protein, ramelteon, xfel, lcp, bril, rubredoxin, circadian rhythm, jetlag, type 2 diabetes |
Biological source | Escherichia coli More |
Total number of polymer chains | 2 |
Total formula weight | 103613.25 |
Authors | Johansson, L.C.,Stauch, B.,McCorvy, J.,Han, G.W.,Patel, N.,Batyuk, A.,Gati, C.,Li, C.,Grandner, J.,Hao, S.,Olsen, R.H.J.,Tribo, A.R.,Zaare, S.,Zhu, L.,Zatsepin, N.A.,Weierstall, U.,Liu, W.,Roth, B.L.,Katritch, V.,Cherezov, V. (deposition date: 2018-09-05, release date: 2019-04-24, Last modification date: 2023-10-11) |
Primary citation | Johansson, L.C.,Stauch, B.,McCorvy, J.D.,Han, G.W.,Patel, N.,Huang, X.P.,Batyuk, A.,Gati, C.,Slocum, S.T.,Li, C.,Grandner, J.M.,Hao, S.,Olsen, R.H.J.,Tribo, A.R.,Zaare, S.,Zhu, L.,Zatsepin, N.A.,Weierstall, U.,Yous, S.,Stevens, R.C.,Liu, W.,Roth, B.L.,Katritch, V.,Cherezov, V. XFEL structures of the human MT2melatonin receptor reveal the basis of subtype selectivity. Nature, 569:289-292, 2019 Cited by PubMed: 31019305DOI: 10.1038/s41586-019-1144-0 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.3 Å) |
Structure validation
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