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PDB: 41 件

8B4V
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X-ray structure of furin (PCSK3) in complex with benzamidine
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, BENZAMIDINE, CALCIUM ION, ...
著者Dahms, S.O, Brandstetter, H.
登録日2022-09-21
公開日2023-10-04
最終更新日2024-05-15
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Fragment-Based Design, Synthesis, and Characterization of Aminoisoindole-Derived Furin Inhibitors.
Chemmedchem, 19, 2024
6A8Y
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YR26_SDS
分子名称: YR26_SDS
著者Sinha, S, Bhattacharjya, S.
登録日2018-07-11
公開日2019-07-17
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献YR26_SDS
To Be Published
1P8J
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CRYSTAL STRUCTURE OF THE PROPROTEIN CONVERTASE FURIN
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, DECANOYL-ARG-VAL-LYS-ARG-CHLOROMETHYLKETONE INHIBITOR, ...
著者Henrich, S, Cameron, A, Bourenkov, G.P, Kiefersauer, R, Huber, R, Lindberg, I, Bode, W, Than, M.E.
登録日2003-05-07
公開日2003-07-08
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献The Crystal Structure of the Proprotein Processing Proteinase Furin Explains its Stringent Specificity
Nat.Struct.Biol., 10, 2003
5JMO
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X-ray structure of furin in complex with the inhibitory antibody Nb14
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, CMK-inhibitor, ...
著者Dahms, S.O, Than, M.E.
登録日2016-04-29
公開日2016-12-07
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.998 Å)
主引用文献The structure of a furin-antibody complex explains non-competitive inhibition by steric exclusion of substrate conformers.
Sci Rep, 6, 2016
6EQX
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BU of 6eqx by Molmil
X-ray structure of the proprotein convertase furin bound with the competitive inhibitor Arg-Arg-Arg-Val-Arg-Amba
分子名称: Arg-Arg-Arg-Val-Arg-00S, CALCIUM ION, CHLORIDE ION, ...
著者Dahms, S.O, Than, M.E.
登録日2017-10-16
公開日2018-02-28
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.994 Å)
主引用文献X-ray Structures of the Proprotein Convertase Furin Bound with Substrate Analogue Inhibitors Reveal Substrate Specificity Determinants beyond the S4 Pocket.
Biochemistry, 57, 2018
8OYH
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BU of 8oyh by Molmil
X-ray structure of furin (PCSK3) in complex with Guanidinomethyl-Phac-Can-Tle-Can-6-(aminomethyl)-3-amino-isoindol
分子名称: CALCIUM ION, CHLORIDE ION, DIMETHYL SULFOXIDE, ...
著者Dahms, S.O, Brandstetter, H.
登録日2023-05-04
公開日2024-03-13
最終更新日2024-05-15
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Fragment-Based Design, Synthesis, and Characterization of Aminoisoindole-Derived Furin Inhibitors.
Chemmedchem, 19, 2024
4Z2A
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BU of 4z2a by Molmil
Crystal structure of unglycosylated apo human furin @1.89A
分子名称: 1,2-ETHANEDIOL, CALCIUM ION, Furin, ...
著者Gampe, R.T, Pearce, K, Reid, R.
登録日2015-03-29
公開日2016-05-04
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.89 Å)
主引用文献BacMam production and crystal structure of nonglycosylated apo human furin at 1.89A resolution
Acta Crystallogr.,Sect.F, 2019
5MIM
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Xray structure of human furin bound with the 2,5-dideoxystreptamine derived small molecule inhibitor 1n
分子名称: 1-[(1~{R},2~{R},4~{S},5~{S})-2,4-bis(4-carbamimidamidophenoxy)-5-[(4-carbamimidamidophenyl)amino]cyclohexyl]guanidine, CALCIUM ION, CHLORIDE ION, ...
著者Dahms, S.O, Guan-Sheng, J, Than, M.E.
登録日2016-11-28
公開日2017-05-10
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural Studies Revealed Active Site Distortions of Human Furin by a Small Molecule Inhibitor.
ACS Chem. Biol., 12, 2017
7O1W
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X-ray structure of furin in complex with the guanylhydrazone-based inhibitor 2 (mi307) soaked at 1 M NaCl
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, CHLORIDE ION, ...
著者Dahms, S.O, Brandstetter, H.
登録日2021-03-30
公開日2021-09-01
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献OFF-State-Specific Inhibition of the Proprotein Convertase Furin.
Acs Chem.Biol., 16, 2021
7O1Y
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X-ray structure of furin in complex with the guanylhydrazone-based inhibitor 2 (mi307) soaked at 0.25 M NaCl
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, CHLORIDE ION, ...
著者Dahms, S.O, Brandstetter, H.
登録日2021-03-30
公開日2021-09-01
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献OFF-State-Specific Inhibition of the Proprotein Convertase Furin.
Acs Chem.Biol., 16, 2021
6EQW
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BU of 6eqw by Molmil
X-ray structure of the proprotein convertase furin bound with the competitive inhibitor 4-aminomethyl-phenylacetyl-Arg-Val-Arg-Amba
分子名称: AMA-ARG-TBG-ARG-00S, CALCIUM ION, CHLORIDE ION, ...
著者Dahms, S.O, Than, M.E.
登録日2017-10-16
公開日2018-02-28
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.994 Å)
主引用文献X-ray Structures of the Proprotein Convertase Furin Bound with Substrate Analogue Inhibitors Reveal Substrate Specificity Determinants beyond the S4 Pocket.
Biochemistry, 57, 2018
6EQV
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BU of 6eqv by Molmil
X-ray structure of the proprotein convertase furin bound with the competitive inhibitor Phac-Cit-Val-Arg-Amba
分子名称: CALCIUM ION, CHLORIDE ION, Furin, ...
著者Dahms, S.O, Than, M.E.
登録日2017-10-16
公開日2018-02-28
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.895 Å)
主引用文献X-ray Structures of the Proprotein Convertase Furin Bound with Substrate Analogue Inhibitors Reveal Substrate Specificity Determinants beyond the S4 Pocket.
Biochemistry, 57, 2018
8B4W
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BU of 8b4w by Molmil
X-ray structure of furin (PCSK3) in complex with 1H-isoindol-3-amine
分子名称: 1H-isoindol-3-amine, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
著者Dahms, S.O, Brandstetter, H.
登録日2022-09-21
公開日2023-10-04
最終更新日2024-05-15
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Fragment-Based Design, Synthesis, and Characterization of Aminoisoindole-Derived Furin Inhibitors.
Chemmedchem, 19, 2024
8B4X
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BU of 8b4x by Molmil
X-ray structure of furin (PCSK3) in complex with Guanidinomethyl-Phac-R-Tle-K-6-(aminomethyl)-3-amino-isoindol
分子名称: CALCIUM ION, CHLORIDE ION, DIMETHYL SULFOXIDE, ...
著者Dahms, S.O, Brandstetter, H.
登録日2022-09-21
公開日2023-10-04
最終更新日2024-05-15
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Fragment-Based Design, Synthesis, and Characterization of Aminoisoindole-Derived Furin Inhibitors.
Chemmedchem, 19, 2024
4OMC
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BU of 4omc by Molmil
X-ray structure of human furin in complex with the competitive inhibitor meta-guanidinomethyl-Phac-RVR-Amba
分子名称: CALCIUM ION, FORMIC ACID, Furin, ...
著者Dahms, S.O, Than, M.E.
登録日2014-01-27
公開日2014-04-09
最終更新日2014-05-28
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献X-ray Structures of Human Furin in Complex with Competitive Inhibitors.
Acs Chem.Biol., 9, 2014
4OMD
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BU of 4omd by Molmil
X-ray structure of human furin in complex with the competitive inhibitor Phac-RVR-Amba
分子名称: CALCIUM ION, FORMIC ACID, Furin, ...
著者Dahms, S.O, Than, M.E.
登録日2014-01-27
公開日2014-04-09
最終更新日2014-05-28
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献X-ray Structures of Human Furin in Complex with Competitive Inhibitors.
Acs Chem.Biol., 9, 2014
4RYD
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BU of 4ryd by Molmil
X-ray structure of human furin in complex with the competitive inhibitor para-guanidinomethyl-Phac-R-Tle-R-Amba
分子名称: CALCIUM ION, FORMIC ACID, Furin, ...
著者Dahms, S.O, Than, M.E.
登録日2014-12-15
公開日2015-05-27
最終更新日2015-07-15
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Novel Furin Inhibitors with Potent Anti-infectious Activity.
Chemmedchem, 10, 2015
5JXH
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BU of 5jxh by Molmil
Structure the proprotein convertase furin in complex with meta-guanidinomethyl-Phac-RVR-Amba at 2.0 Angstrom resolution.
分子名称: 2UC-ARG-VAL-ARG-00S, CALCIUM ION, CHLORIDE ION, ...
著者Dahms, S.O, Arciniega, M, Steinmetzer, T, Huber, R, Than, M.E.
登録日2016-05-13
公開日2016-10-05
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structure of the unliganded form of the proprotein convertase furin suggests activation by a substrate-induced mechanism.
Proc.Natl.Acad.Sci.USA, 113, 2016
7LCU
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BU of 7lcu by Molmil
X-ray structure of Furin bound to BOS-318, a small molecule inhibitor
分子名称: (1-{[2-(3,5-dichlorophenyl)-6-{[2-(4-methylpiperazin-1-yl)pyrimidin-5-yl]oxy}pyridin-4-yl]methyl}piperidin-4-yl)acetic acid, 1,2-ETHANEDIOL, CALCIUM ION, ...
著者Campobasso, N, Reid, R.
登録日2021-01-11
公開日2022-01-12
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.24 Å)
主引用文献A highly selective, cell-permeable furin inhibitor BOS-318 rescues key features of cystic fibrosis airway disease.
Cell Chem Biol, 29, 2022
5JXJ
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Structure of the proprotein convertase furin complexed to meta-guanidinomethyl-Phac-RVR-Amba in presence of EDTA
分子名称: 2UC-ARG-VAL-ARG-00S, CALCIUM ION, CHLORIDE ION, ...
著者Dahms, S.O, Arciniega, M, Steinmetzer, T, Huber, R, Than, M.E.
登録日2016-05-13
公開日2016-10-05
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structure of the unliganded form of the proprotein convertase furin suggests activation by a substrate-induced mechanism.
Proc.Natl.Acad.Sci.USA, 113, 2016
5JXI
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BU of 5jxi by Molmil
Structure of the unliganded form of the proprotein convertase furin in presence of EDTA.
分子名称: CALCIUM ION, CHLORIDE ION, Furin, ...
著者Dahms, S.O, Arciniega, M, Steinmetzer, T, Huber, R, Than, M.E.
登録日2016-05-13
公開日2016-10-05
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structure of the unliganded form of the proprotein convertase furin suggests activation by a substrate-induced mechanism.
Proc.Natl.Acad.Sci.USA, 113, 2016
5JXG
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BU of 5jxg by Molmil
Structure of the unliganded form of the proprotein convertase furin.
分子名称: CALCIUM ION, CHLORIDE ION, Furin, ...
著者Dahms, S.O, Arciniega, M, Steinmetzer, T, Huber, R, Than, M.E.
登録日2016-05-13
公開日2016-10-05
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structure of the unliganded form of the proprotein convertase furin suggests activation by a substrate-induced mechanism.
Proc.Natl.Acad.Sci.USA, 113, 2016
6YD7
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BU of 6yd7 by Molmil
X-ray structure of furin in complex with the canavanine-based inhibitor 4-guanidinomethyl-phenylacetyl-Arg-Tle-Canavanine-Amba
分子名称: 4-guanidinomethyl-phenylacetyl-Arg-Tle-Canavanine-Amba, CALCIUM ION, CHLORIDE ION, ...
著者Dahms, S.O.
登録日2020-03-20
公開日2021-02-17
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献The Basicity Makes the Difference: Improved Canavanine-Derived Inhibitors of the Proprotein Convertase Furin.
Acs Med.Chem.Lett., 12, 2021
6YD4
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BU of 6yd4 by Molmil
X-ray structure of furin in complex with the canavanine-based inhibitor 4-guanidinomethyl-phenylacetyl-Canavanine-Tle-Canavanine-Amba
分子名称: 4-guanidinomethyl-phenylacetyl-Canavanine-Tle-Canavanine-Amba, CALCIUM ION, CHLORIDE ION, ...
著者Dahms, S.O.
登録日2020-03-20
公開日2021-02-17
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献The Basicity Makes the Difference: Improved Canavanine-Derived Inhibitors of the Proprotein Convertase Furin.
Acs Med.Chem.Lett., 12, 2021
6YD2
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BU of 6yd2 by Molmil
X-ray structure of furin in complex with the canavanine-based inhibitor 4-aminomethyl-phenylacetyl-canavanine-Tle-Arg-Amba
分子名称: 4-aminomethyl-phenylacetyl-canavanine-Tle-Arg-Amba, CALCIUM ION, CHLORIDE ION, ...
著者Dahms, S.O.
登録日2020-03-20
公開日2021-02-17
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献The Basicity Makes the Difference: Improved Canavanine-Derived Inhibitors of the Proprotein Convertase Furin.
Acs Med.Chem.Lett., 12, 2021

 

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