4RYD

X-ray structure of human furin in complex with the competitive inhibitor para-guanidinomethyl-Phac-R-Tle-R-Amba

Summary for 4RYD

Related4OMC 4OMD 1P8J
Related PRD IDPRD_001257
DescriptorFurin, para-guanidinomethyl-phenylacetyl-Arg-(3-methylvaline)-Arg-(amidomethyl)benzamidine, FORMIC ACID, ... (6 entities in total)
Functional Keywordscompetitive inhibitor, pro-protein convertase, serine protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationGolgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein P09958
Total number of polymer chains12
Total molecular weight320519.12
Authors
Dahms, S.O.,Than, M.E. (deposition date: 2014-12-15, release date: 2015-05-27, Last modification date: 2015-07-15)
Primary citation
Hardes, K.,Becker, G.L.,Lu, Y.,Dahms, S.O.,Kohler, S.,Beyer, W.,Sandvig, K.,Yamamoto, H.,Lindberg, I.,Walz, L.,von Messling, V.,Than, M.E.,Garten, W.,Steinmetzer, T.
Novel Furin Inhibitors with Potent Anti-infectious Activity.
Chemmedchem, 10:1218-1231, 2015
PubMed: 25974265 (PDB entries with the same primary citation)
DOI: 10.1002/cmdc.201500103
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.15 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.21960.1%2.7%1.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 4ryd
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More Biological unit images

Molmil generated image of 4ryd
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Molmil generated image of 4ryd
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Molmil generated image of 4ryd
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(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (4ryd.pdb4.gz [88.36 KB])
Coordinate files for Biological unit (4ryd.pdb2.gz [88.07 KB])
Coordinate files for Biological unit (4ryd.pdb5.gz [88.88 KB])
Coordinate files for Biological unit (4ryd.pdb1.gz [88.75 KB])
Coordinate files for Biological unit (4ryd.pdb3.gz [88.9 KB])
Coordinate files for Biological unit (4ryd.pdb6.gz [87.94 KB])