4RYD
X-ray structure of human furin in complex with the competitive inhibitor para-guanidinomethyl-Phac-R-Tle-R-Amba
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D, E... | Furin | polymer | 482 | 52388.6 | 6 | UniProt (P09958) Pfam (PF00082) Pfam (PF01483) In PDB | Homo sapiens (human) | Dibasic-processing enzyme, Paired basic amino acid residue-cleaving enzyme, PACE |
2 | H, I, J, K, L... | para-guanidinomethyl-phenylacetyl-Arg-(3-methylvaline)-Arg-(amidomethyl)benzamidine | polymer | 5 | 750.0 | 6 | BIRD (PRD_001257) | ||
3 | C, D, A, E, B... | FORMIC ACID | non-polymer | 46.0 | 18 | Chemie (FMT) | |||
4 | F, C, D, A, E... | CALCIUM ION | non-polymer | 40.1 | 18 | Chemie (CA) | |||
5 | F, C, D, A, E... | SODIUM ION | non-polymer | 23.0 | 6 | Chemie (NA) | |||
6 | water | water | 18.0 | 2034 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F: 108 - 574 (UniProt: P09958)
PDB | External Database | Details |
---|---|---|
Ser 575 | - | expression tag |
Gly 576 | - | expression tag |
Ser 577 | - | expression tag |
Leu 578 | - | expression tag |
Val 579 | - | expression tag |
Pro 580 | - | expression tag |
Arg 581 | - | expression tag |
Gly 582 | - | expression tag |
Ser 583 | - | expression tag |
His 584 | - | expression tag |
His 585 | - | expression tag |
His 586 | - | expression tag |
His 587 | - | expression tag |
His 588 | - | expression tag |
His 589 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 12 |
Total formula weight | 318831.3 | |
Non-Polymers* | Number of molecules | 42 |
Total formula weight | 1687.8 | |
All* | Total formula weight | 320519.1 |