4RYD
X-ray structure of human furin in complex with the competitive inhibitor para-guanidinomethyl-Phac-R-Tle-R-Amba
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004252 | molecular_function | serine-type endopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| A | 0008236 | molecular_function | serine-type peptidase activity |
| B | 0004252 | molecular_function | serine-type endopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
| B | 0008236 | molecular_function | serine-type peptidase activity |
| C | 0004252 | molecular_function | serine-type endopeptidase activity |
| C | 0006508 | biological_process | proteolysis |
| C | 0008236 | molecular_function | serine-type peptidase activity |
| D | 0004252 | molecular_function | serine-type endopeptidase activity |
| D | 0006508 | biological_process | proteolysis |
| D | 0008236 | molecular_function | serine-type peptidase activity |
| E | 0004252 | molecular_function | serine-type endopeptidase activity |
| E | 0006508 | biological_process | proteolysis |
| E | 0008236 | molecular_function | serine-type peptidase activity |
| F | 0004252 | molecular_function | serine-type endopeptidase activity |
| F | 0006508 | biological_process | proteolysis |
| F | 0008236 | molecular_function | serine-type peptidase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE FMT A 601 |
| Chain | Residue |
| A | ASN295 |
| A | THR365 |
| A | GLY366 |
| A | HOH760 |
| E | ARG298 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE FMT A 602 |
| Chain | Residue |
| B | GLN280 |
| A | TYR313 |
| A | GLN447 |
| A | FMT603 |
| B | ARG276 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE FMT A 603 |
| Chain | Residue |
| A | PHE275 |
| A | TYR313 |
| A | LYS449 |
| A | TYR571 |
| A | FMT602 |
| B | ARG276 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 604 |
| Chain | Residue |
| A | ASP115 |
| A | ASP162 |
| A | VAL205 |
| A | ASN208 |
| A | VAL210 |
| A | GLY212 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 605 |
| Chain | Residue |
| A | ASP258 |
| A | ASP301 |
| A | GLU331 |
| A | HOH756 |
| A | HOH771 |
| A | HOH852 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 606 |
| Chain | Residue |
| A | ASP174 |
| A | ASP179 |
| A | ASP181 |
| A | HOH729 |
| A | HOH734 |
| A | HOH902 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NA A 607 |
| Chain | Residue |
| A | THR309 |
| A | SER311 |
| A | THR314 |
| A | HOH784 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE FMT B 601 |
| Chain | Residue |
| A | ARG276 |
| A | GLN280 |
| B | TYR313 |
| B | GLN447 |
| B | FMT602 |
| B | HOH751 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE FMT B 602 |
| Chain | Residue |
| A | ARG276 |
| B | PHE275 |
| B | TYR313 |
| B | LYS449 |
| B | FMT601 |
| site_id | BC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE FMT B 603 |
| Chain | Residue |
| B | THR365 |
| B | HOH831 |
| D | ARG298 |
| site_id | BC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA B 604 |
| Chain | Residue |
| B | ASP115 |
| B | ASP162 |
| B | VAL205 |
| B | ASN208 |
| B | VAL210 |
| B | GLY212 |
| site_id | BC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA B 605 |
| Chain | Residue |
| B | ASP258 |
| B | ASP301 |
| B | GLU331 |
| B | HOH716 |
| B | HOH744 |
| B | HOH837 |
| site_id | BC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA B 606 |
| Chain | Residue |
| B | ASP174 |
| B | ASP179 |
| B | ASP181 |
| B | HOH772 |
| B | HOH810 |
| B | HOH838 |
| site_id | BC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NA B 607 |
| Chain | Residue |
| B | THR309 |
| B | SER311 |
| B | THR314 |
| B | HOH703 |
| site_id | BC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE FMT C 601 |
| Chain | Residue |
| C | ASN295 |
| C | THR365 |
| C | GLY366 |
| C | HOH875 |
| F | ARG298 |
| site_id | BC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE FMT C 602 |
| Chain | Residue |
| C | PHE275 |
| C | GLN447 |
| C | FMT603 |
| C | HOH785 |
| D | ARG276 |
| D | GLN280 |
| site_id | BC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE FMT C 603 |
| Chain | Residue |
| C | PHE275 |
| C | TYR313 |
| C | LYS449 |
| C | TYR571 |
| C | FMT602 |
| D | ARG276 |
| site_id | BC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA C 604 |
| Chain | Residue |
| C | ASP115 |
| C | ASP162 |
| C | VAL205 |
| C | ASN208 |
| C | VAL210 |
| C | GLY212 |
| site_id | CC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA C 605 |
| Chain | Residue |
| C | GLU331 |
| C | HOH728 |
| C | HOH750 |
| C | HOH791 |
| C | ASP258 |
| C | ASP301 |
| site_id | CC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA C 606 |
| Chain | Residue |
| C | ASP174 |
| C | ASP179 |
| C | ASP181 |
| C | HOH800 |
| C | HOH803 |
| C | HOH859 |
| site_id | CC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NA C 607 |
| Chain | Residue |
| C | THR309 |
| C | SER311 |
| C | THR314 |
| C | HOH721 |
| site_id | CC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE FMT D 601 |
| Chain | Residue |
| C | ARG276 |
| C | GLN280 |
| D | TYR313 |
| D | GLN447 |
| D | FMT602 |
| D | HOH772 |
| site_id | CC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE FMT D 602 |
| Chain | Residue |
| C | ARG276 |
| D | PHE275 |
| D | TYR313 |
| D | LYS449 |
| D | FMT601 |
| site_id | CC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE FMT D 603 |
| Chain | Residue |
| B | ARG298 |
| D | TRP328 |
| D | THR365 |
| D | GLY366 |
| site_id | CC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA D 604 |
| Chain | Residue |
| D | ASP115 |
| D | ASP162 |
| D | VAL205 |
| D | ASN208 |
| D | VAL210 |
| D | GLY212 |
| site_id | CC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA D 605 |
| Chain | Residue |
| D | ASP258 |
| D | ASP301 |
| D | GLU331 |
| D | HOH710 |
| D | HOH727 |
| D | HOH832 |
| site_id | CC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA D 606 |
| Chain | Residue |
| D | ASP174 |
| D | ASP179 |
| D | ASP181 |
| D | HOH722 |
| D | HOH754 |
| D | HOH833 |
| site_id | DC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NA D 607 |
| Chain | Residue |
| D | THR309 |
| D | SER311 |
| D | THR314 |
| D | HOH723 |
| site_id | DC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE FMT E 601 |
| Chain | Residue |
| E | THR365 |
| E | GLY366 |
| E | HOH912 |
| site_id | DC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE FMT E 602 |
| Chain | Residue |
| E | PHE275 |
| E | TYR313 |
| E | GLN447 |
| E | FMT603 |
| F | ARG276 |
| site_id | DC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE FMT E 603 |
| Chain | Residue |
| E | PHE275 |
| E | TYR313 |
| E | LYS449 |
| E | TYR571 |
| E | FMT602 |
| F | ARG276 |
| site_id | DC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA E 604 |
| Chain | Residue |
| E | ASP115 |
| E | ASP162 |
| E | VAL205 |
| E | ASN208 |
| E | VAL210 |
| E | GLY212 |
| site_id | DC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA E 605 |
| Chain | Residue |
| E | ASP258 |
| E | ASP301 |
| E | GLU331 |
| E | HOH720 |
| E | HOH721 |
| E | HOH839 |
| site_id | DC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA E 606 |
| Chain | Residue |
| E | ASP174 |
| E | ASP179 |
| E | ASP181 |
| E | HOH840 |
| E | HOH877 |
| E | HOH920 |
| site_id | DC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NA E 607 |
| Chain | Residue |
| E | THR309 |
| E | SER311 |
| E | THR314 |
| E | HOH704 |
| site_id | DC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE FMT F 601 |
| Chain | Residue |
| E | ARG276 |
| F | TYR313 |
| F | TRP390 |
| F | GLN447 |
| F | FMT602 |
| F | HOH891 |
| site_id | EC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE FMT F 602 |
| Chain | Residue |
| E | ARG276 |
| F | PHE275 |
| F | TYR313 |
| F | LYS449 |
| F | TYR571 |
| F | FMT601 |
| site_id | EC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE FMT F 603 |
| Chain | Residue |
| C | ARG298 |
| F | ASN295 |
| F | TRP328 |
| F | THR365 |
| F | GLY366 |
| F | HOH863 |
| site_id | EC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA F 604 |
| Chain | Residue |
| F | ASP115 |
| F | ASP162 |
| F | VAL205 |
| F | ASN208 |
| F | VAL210 |
| F | GLY212 |
| site_id | EC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA F 605 |
| Chain | Residue |
| F | ASP258 |
| F | ASP301 |
| F | GLU331 |
| F | HOH704 |
| F | HOH722 |
| F | HOH770 |
| site_id | EC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA F 606 |
| Chain | Residue |
| F | ASP174 |
| F | ASP179 |
| F | ASP181 |
| F | HOH748 |
| F | HOH778 |
| F | HOH819 |
| site_id | EC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NA F 607 |
| Chain | Residue |
| F | THR309 |
| F | SER311 |
| F | THR314 |
| F | HOH716 |
| site_id | EC7 |
| Number of Residues | 30 |
| Details | BINDING SITE FOR CHAIN H OF PARA-GUANIDINOMETHYL-PHENYLACETYL-ARG-(3-METHYLVALINE)-ARG- (AMIDOMETHYL)BENZAMIDINE |
| Chain | Residue |
| A | ASP154 |
| A | ASP191 |
| A | ASN192 |
| A | HIS194 |
| A | VAL231 |
| A | THR232 |
| A | ASP233 |
| A | GLU236 |
| A | SER253 |
| A | TRP254 |
| A | GLY255 |
| A | PRO256 |
| A | GLU257 |
| A | ASP258 |
| A | ASP264 |
| A | GLY265 |
| A | ALA267 |
| A | ALA292 |
| A | ASP306 |
| A | TYR308 |
| A | THR309 |
| A | THR367 |
| A | SER368 |
| A | HOH715 |
| A | HOH948 |
| A | HOH987 |
| H | HOH101 |
| H | HOH102 |
| H | HOH103 |
| H | HOH104 |
| site_id | EC8 |
| Number of Residues | 28 |
| Details | BINDING SITE FOR CHAIN I OF PARA-GUANIDINOMETHYL-PHENYLACETYL-ARG-(3-METHYLVALINE)-ARG- (AMIDOMETHYL)BENZAMIDINE |
| Chain | Residue |
| B | ASP154 |
| B | ASP191 |
| B | ASN192 |
| B | HIS194 |
| B | VAL231 |
| B | THR232 |
| B | GLU236 |
| B | SER253 |
| B | TRP254 |
| B | GLY255 |
| B | PRO256 |
| B | GLU257 |
| B | ASP258 |
| B | ASP264 |
| B | GLY265 |
| B | ALA292 |
| B | ASP306 |
| B | TYR308 |
| B | THR309 |
| B | THR367 |
| B | SER368 |
| B | HOH701 |
| B | HOH973 |
| B | HOH1022 |
| B | HOH1023 |
| I | HOH101 |
| I | HOH102 |
| I | HOH103 |
| site_id | EC9 |
| Number of Residues | 28 |
| Details | BINDING SITE FOR CHAIN J OF PARA-GUANIDINOMETHYL-PHENYLACETYL-ARG-(3-METHYLVALINE)-ARG- (AMIDOMETHYL)BENZAMIDINE |
| Chain | Residue |
| C | ASP154 |
| C | ASP191 |
| C | ASN192 |
| C | HIS194 |
| C | VAL231 |
| C | THR232 |
| C | GLU236 |
| C | SER253 |
| C | TRP254 |
| C | GLY255 |
| C | PRO256 |
| C | GLU257 |
| C | ASP258 |
| C | ASP264 |
| C | GLY265 |
| C | ALA292 |
| C | SER293 |
| C | ASP306 |
| C | TYR308 |
| C | THR309 |
| C | THR367 |
| C | SER368 |
| C | HOH711 |
| J | HOH101 |
| J | HOH102 |
| J | HOH103 |
| J | HOH104 |
| J | HOH105 |
| site_id | FC1 |
| Number of Residues | 31 |
| Details | BINDING SITE FOR CHAIN K OF PARA-GUANIDINOMETHYL-PHENYLACETYL-ARG-(3-METHYLVALINE)-ARG- (AMIDOMETHYL)BENZAMIDINE |
| Chain | Residue |
| D | ASP154 |
| D | ASP191 |
| D | ASN192 |
| D | HIS194 |
| D | VAL231 |
| D | THR232 |
| D | ASP233 |
| D | GLU236 |
| D | SER253 |
| D | TRP254 |
| D | GLY255 |
| D | PRO256 |
| D | GLU257 |
| D | ASP258 |
| D | ASP264 |
| D | GLY265 |
| D | ALA292 |
| D | ASP306 |
| D | TYR308 |
| D | THR309 |
| D | THR367 |
| D | SER368 |
| D | HOH1011 |
| D | HOH1012 |
| K | HOH101 |
| K | HOH102 |
| K | HOH103 |
| K | HOH104 |
| K | HOH105 |
| K | HOH106 |
| K | HOH107 |
| site_id | FC2 |
| Number of Residues | 28 |
| Details | BINDING SITE FOR CHAIN L OF PARA-GUANIDINOMETHYL-PHENYLACETYL-ARG-(3-METHYLVALINE)-ARG- (AMIDOMETHYL)BENZAMIDINE |
| Chain | Residue |
| E | ASP154 |
| E | ASP191 |
| E | ASN192 |
| E | HIS194 |
| E | VAL231 |
| E | THR232 |
| E | GLU236 |
| E | SER253 |
| E | TRP254 |
| E | GLY255 |
| E | PRO256 |
| E | GLU257 |
| E | ASP258 |
| E | ASP264 |
| E | GLY265 |
| E | ALA292 |
| E | ASN295 |
| E | ASP306 |
| E | TYR308 |
| E | THR309 |
| E | THR367 |
| E | SER368 |
| E | HOH703 |
| E | HOH744 |
| L | HOH101 |
| L | HOH102 |
| L | HOH103 |
| L | HOH104 |
| site_id | FC3 |
| Number of Residues | 29 |
| Details | BINDING SITE FOR CHAIN N OF PARA-GUANIDINOMETHYL-PHENYLACETYL-ARG-(3-METHYLVALINE)-ARG- (AMIDOMETHYL)BENZAMIDINE |
| Chain | Residue |
| F | ASP154 |
| F | ASP191 |
| F | ASN192 |
| F | HIS194 |
| F | VAL231 |
| F | THR232 |
| F | ASP233 |
| F | GLU236 |
| F | SER253 |
| F | TRP254 |
| F | GLY255 |
| F | PRO256 |
| F | GLU257 |
| F | ASP258 |
| F | ASP264 |
| F | GLY265 |
| F | ALA292 |
| F | ASP306 |
| F | TYR308 |
| F | THR309 |
| F | THR367 |
| F | SER368 |
| F | HOH701 |
| F | HOH999 |
| N | HOH101 |
| N | HOH102 |
| N | HOH103 |
| N | HOH104 |
| N | HOH105 |
Functional Information from PROSITE/UniProt
| site_id | PS00136 |
| Number of Residues | 12 |
| Details | SUBTILASE_ASP Serine proteases, subtilase family, aspartic acid active site. VSILDDGIeknH |
| Chain | Residue | Details |
| A | VAL149-HIS160 |
| site_id | PS00137 |
| Number of Residues | 11 |
| Details | SUBTILASE_HIS Serine proteases, subtilase family, histidine active site. HGTrCAGeVAA |
| Chain | Residue | Details |
| A | HIS194-ALA204 |
| site_id | PS00138 |
| Number of Residues | 11 |
| Details | SUBTILASE_SER Serine proteases, subtilase family, serine active site. GTSaSaPlAAG |
| Chain | Residue | Details |
| A | GLY366-GLY376 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 18 |
| Details | ACT_SITE: Charge relay system => ECO:0000255|PROSITE-ProRule:PRU01240 |
| Chain | Residue | Details |
| A | ASP153 | |
| D | ASP153 | |
| D | HIS194 | |
| D | SER368 | |
| E | ASP153 | |
| E | HIS194 | |
| E | SER368 | |
| F | ASP153 | |
| F | HIS194 | |
| F | SER368 | |
| A | HIS194 | |
| A | SER368 | |
| B | ASP153 | |
| B | HIS194 | |
| B | SER368 | |
| C | ASP153 | |
| C | HIS194 | |
| C | SER368 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 72 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:24666235, ECO:0000269|PubMed:25974265, ECO:0007744|PDB:4OMC, ECO:0007744|PDB:4OMD, ECO:0007744|PDB:4RYD |
| Chain | Residue | Details |
| A | ASP115 | |
| A | ASP258 | |
| A | ASP301 | |
| A | GLU331 | |
| B | ASP115 | |
| B | ASP162 | |
| B | ASP174 | |
| B | ASP179 | |
| B | ASP181 | |
| B | VAL205 | |
| B | ASN208 | |
| A | ASP162 | |
| B | VAL210 | |
| B | GLY212 | |
| B | ASP258 | |
| B | ASP301 | |
| B | GLU331 | |
| C | ASP115 | |
| C | ASP162 | |
| C | ASP174 | |
| C | ASP179 | |
| C | ASP181 | |
| A | ASP174 | |
| C | VAL205 | |
| C | ASN208 | |
| C | VAL210 | |
| C | GLY212 | |
| C | ASP258 | |
| C | ASP301 | |
| C | GLU331 | |
| D | ASP115 | |
| D | ASP162 | |
| D | ASP174 | |
| A | ASP179 | |
| D | ASP179 | |
| D | ASP181 | |
| D | VAL205 | |
| D | ASN208 | |
| D | VAL210 | |
| D | GLY212 | |
| D | ASP258 | |
| D | ASP301 | |
| D | GLU331 | |
| E | ASP115 | |
| A | ASP181 | |
| E | ASP162 | |
| E | ASP174 | |
| E | ASP179 | |
| E | ASP181 | |
| E | VAL205 | |
| E | ASN208 | |
| E | VAL210 | |
| E | GLY212 | |
| E | ASP258 | |
| E | ASP301 | |
| A | VAL205 | |
| E | GLU331 | |
| F | ASP115 | |
| F | ASP162 | |
| F | ASP174 | |
| F | ASP179 | |
| F | ASP181 | |
| F | VAL205 | |
| F | ASN208 | |
| F | VAL210 | |
| F | GLY212 | |
| A | ASN208 | |
| F | ASP258 | |
| F | ASP301 | |
| F | GLU331 | |
| A | VAL210 | |
| A | GLY212 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 54 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:24666235, ECO:0000305|PubMed:25974265, ECO:0007744|PDB:4OMC, ECO:0007744|PDB:4OMD, ECO:0007744|PDB:4RYD |
| Chain | Residue | Details |
| A | ASP154 | |
| B | ASP154 | |
| B | ASP191 | |
| B | GLU236 | |
| B | SER253 | |
| B | ASP264 | |
| B | ALA292 | |
| B | ASP306 | |
| B | TYR308 | |
| B | SER368 | |
| C | ASP154 | |
| A | ASP191 | |
| C | ASP191 | |
| C | GLU236 | |
| C | SER253 | |
| C | ASP264 | |
| C | ALA292 | |
| C | ASP306 | |
| C | TYR308 | |
| C | SER368 | |
| D | ASP154 | |
| D | ASP191 | |
| A | GLU236 | |
| D | GLU236 | |
| D | SER253 | |
| D | ASP264 | |
| D | ALA292 | |
| D | ASP306 | |
| D | TYR308 | |
| D | SER368 | |
| E | ASP154 | |
| E | ASP191 | |
| E | GLU236 | |
| A | SER253 | |
| E | SER253 | |
| E | ASP264 | |
| E | ALA292 | |
| E | ASP306 | |
| E | TYR308 | |
| E | SER368 | |
| F | ASP154 | |
| F | ASP191 | |
| F | GLU236 | |
| F | SER253 | |
| A | ASP264 | |
| F | ASP264 | |
| F | ALA292 | |
| F | ASP306 | |
| F | TYR308 | |
| F | SER368 | |
| A | ALA292 | |
| A | ASP306 | |
| A | TYR308 | |
| A | SER368 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 18 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN387 | |
| D | ASN387 | |
| D | ASN440 | |
| D | ASN553 | |
| E | ASN387 | |
| E | ASN440 | |
| E | ASN553 | |
| F | ASN387 | |
| F | ASN440 | |
| F | ASN553 | |
| A | ASN440 | |
| A | ASN553 | |
| B | ASN387 | |
| B | ASN440 | |
| B | ASN553 | |
| C | ASN387 | |
| C | ASN440 | |
| C | ASN553 |
