8OYH
X-ray structure of furin (PCSK3) in complex with Guanidinomethyl-Phac-Can-Tle-Can-6-(aminomethyl)-3-amino-isoindol
Summary for 8OYH
Entry DOI | 10.2210/pdb8oyh/pdb |
Descriptor | Furin, Guanidinomethyl-Phac-Can-Tle-Can-6-(aminomethyl)-3-amino-isoindol, CALCIUM ION, ... (7 entities in total) |
Functional Keywords | furin, proprotein convertase subtilisin/kexin type 3, pcsk3, sars-cov-2, inhibitor, protease, complex, hydrolase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 53274.14 |
Authors | |
Primary citation | Lange, R.W.,Bloch, K.,Heindl, M.R.,Wollenhaupt, J.,Weiss, M.S.,Brandstetter, H.,Klebe, G.,Falcone, F.H.,Bottcher-Friebertshauser, E.,Dahms, S.O.,Steinmetzer, T. Fragment-Based Design, Synthesis, and Characterization of Aminoisoindole-Derived Furin Inhibitors. Chemmedchem, :e202400057-e202400057, 2024 Cited by PubMed: 38385828DOI: 10.1002/cmdc.202400057 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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