8B4W
X-ray structure of furin (PCSK3) in complex with 1H-isoindol-3-amine
Summary for 8B4W
Entry DOI | 10.2210/pdb8b4w/pdb |
Descriptor | Furin, 1H-isoindol-3-amine, CALCIUM ION, ... (8 entities in total) |
Functional Keywords | furin, proprotein convertase subtilisin/kexin type 3, pcsk3, sars-cov-2, inhibitor, protease, complex, hydrolase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 53212.05 |
Authors | Dahms, S.O.,Brandstetter, H. (deposition date: 2022-09-21, release date: 2023-10-04, Last modification date: 2024-05-15) |
Primary citation | Lange, R.W.,Bloch, K.,Heindl, M.R.,Wollenhaupt, J.,Weiss, M.S.,Brandstetter, H.,Klebe, G.,Falcone, F.H.,Bottcher-Friebertshauser, E.,Dahms, S.O.,Steinmetzer, T. Fragment-Based Design, Synthesis, and Characterization of Aminoisoindole-Derived Furin Inhibitors. Chemmedchem, 19:e202400057-e202400057, 2024 Cited by PubMed: 38385828DOI: 10.1002/cmdc.202400057 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
Download full validation report![Download](/newweb/media/icons/dl.png)
![Download](/newweb/media/icons/dl.png)