7LCU

X-ray structure of Furin bound to BOS-318, a small molecule inhibitor

Summary for 7LCU

• Entry DOI: 10.2210/pdb7lcu/pdb
• Descriptor: Furin, CALCIUM ION, (1-{[2-(3,5-dichlorophenyl)-6-{[2-(4-methylpiperazin-1-yl)pyrimidin-5-yl]oxy}pyridin-4-yl]methyl}piperidin-4-yl)acetic acid, ... (5 entities in total)
• Functional Keywords: inhibitor protease, hydrolase-inhibitor complex, hydrolase/inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 54367.55

Authors

Campobasso, N.,Reid, R. (deposition date: 2021-01-11, release date: 2022-01-12, Last modification date: 2023-10-18)

• Primary citation: Douglas, L.E.J.,Reihill, J.A.,Ho, M.W.Y.,Axten, J.M.,Campobasso, N.,Schneck, J.L.,Rendina, A.R.,Wilcoxen, K.M.,Martin, S.L.; A highly selective, cell-permeable furin inhibitor BOS-318 rescues key features of cystic fibrosis airway disease.; Cell Chem Biol, 29:947-957.e8, 2022; PubMed: 35202587; DOI: 10.1016/j.chembiol.2022.02.001

Experimental method

X-RAY DIFFRACTION (1.24 Å)