8AG4
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8ag4 by Molmil](/molmil-images/mine/8ag4) | Vaccinia C16 protein bound to Ku70/Ku80 | 分子名称: | Protein C10, X-ray repair cross-complementing protein 5, X-ray repair cross-complementing protein 6 | 著者 | Rivera-Calzada, A, Arribas-Bosacoma, R, Pearl, L.H, Llorca, O. | 登録日 | 2022-07-19 | 公開日 | 2022-11-09 | 最終更新日 | 2022-11-30 | 実験手法 | ELECTRON MICROSCOPY (2.46 Å) | 主引用文献 | Structural basis for the inactivation of cytosolic DNA sensing by the vaccinia virus. Nat Commun, 13, 2022
|
|
1JEY
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1jey by Molmil](/molmil-images/mine/1jey) | Crystal Structure of the Ku heterodimer bound to DNA | 分子名称: | DNA (34-MER), DNA (5'-D(*GP*TP*TP*TP*TP*TP*AP*GP*TP*TP*TP*AP*TP*TP*GP*GP*GP*CP*GP*CP*G)-3'), Ku70, ... | 著者 | Walker, J.R, Corpina, R.A, Goldberg, J. | 登録日 | 2001-06-19 | 公開日 | 2001-08-10 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair. Nature, 412, 2001
|
|
3RZX
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3rzx by Molmil](/molmil-images/mine/3rzx) | |
7ZYG
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7zyg by Molmil](/molmil-images/mine/7zyg) | CryoEM structure of Ku heterodimer bound to DNA, PAXX and XLF | 分子名称: | DNA, Non-homologous end-joining factor 1, PHOSPHATE ION, ... | 著者 | Hardwick, S.W, Kefala-Stavridi, A, Chirgadze, D.Y, Blundell, T.L, Chaplin, A.K. | 登録日 | 2022-05-24 | 公開日 | 2023-06-07 | 最終更新日 | 2023-06-14 | 実験手法 | ELECTRON MICROSCOPY (2.68 Å) | 主引用文献 | PAXX binding to the NHEJ machinery explains functional redundancy with XLF. Sci Adv, 9, 2023
|
|
1JEQ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1jeq by Molmil](/molmil-images/mine/1jeq) | |
7ZVT
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7zvt by Molmil](/molmil-images/mine/7zvt) | CryoEM structure of Ku heterodimer bound to DNA | 分子名称: | DNA (5'-D(P*CP*GP*AP*TP*AP*TP*CP*TP*AP*GP*AP*GP*GP*GP*AP*T)-3'), DNA (5'-D(P*TP*CP*CP*CP*TP*CP*TP*AP*GP*AP*TP*AP*TP*C)-3'), INOSITOL HEXAKISPHOSPHATE, ... | 著者 | Hardwick, S.W, Kefala-Stavridi, A, Chirgadze, D.Y, Blundell, T.L, Chaplin, A.K. | 登録日 | 2022-05-17 | 公開日 | 2023-05-24 | 最終更新日 | 2023-12-06 | 実験手法 | ELECTRON MICROSCOPY (2.74 Å) | 主引用文献 | Structural and functional basis of inositol hexaphosphate stimulation of NHEJ through stabilization of Ku-XLF interaction. Nucleic Acids Res., 51, 2023
|
|
6ERH
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6erh by Molmil](/molmil-images/mine/6erh) | Complex of XLF and heterodimer Ku bound to DNA | 分子名称: | DNA (21-MER), DNA (34-MER), Non-homologous end-joining factor 1, ... | 著者 | Nemoz, C, Legrand, P, Ropars, V, Charbonnier, J.B. | 登録日 | 2017-10-18 | 公開日 | 2018-10-17 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | XLF and APLF bind Ku80 at two remote sites to ensure DNA repair by non-homologous end joining. Nat. Struct. Mol. Biol., 25, 2018
|
|
7ZWA
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7zwa by Molmil](/molmil-images/mine/7zwa) | CryoEM structure of Ku heterodimer bound to DNA and PAXX | 分子名称: | DNA (5'-D(P*CP*GP*AP*TP*AP*TP*CP*TP*AP*GP*AP*GP*GP*GP*AP*TP*C)-3'), DNA (5'-D(P*GP*AP*TP*CP*CP*CP*TP*CP*TP*AP*GP*AP*TP*AP*T)-3'), PHOSPHATE ION, ... | 著者 | Hardwick, S.W, Kefala-Stavridi, A, Chirgadze, D.Y, Blundell, T.L, Chaplin, A.K. | 登録日 | 2022-05-19 | 公開日 | 2023-05-31 | 最終更新日 | 2023-06-14 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | PAXX binding to the NHEJ machinery explains functional redundancy with XLF. Sci Adv, 9, 2023
|
|
6ERG
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6erg by Molmil](/molmil-images/mine/6erg) | Complex of XLF and heterodimer Ku bound to DNA | 分子名称: | DNA (21-MER), DNA (34-MER), Non-homologous end-joining factor 1, ... | 著者 | Nemoz, C, Legrand, P, Ropars, V, Charbonnier, J.B. | 登録日 | 2017-10-18 | 公開日 | 2018-10-17 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | XLF and APLF bind Ku80 at two remote sites to ensure DNA repair by non-homologous end joining. Nat. Struct. Mol. Biol., 25, 2018
|
|
7Z87
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7z87 by Molmil](/molmil-images/mine/7z87) | DNA-PK in the active state | 分子名称: | (~{S})-[2-chloranyl-4-fluoranyl-5-(7-morpholin-4-ylquinazolin-4-yl)phenyl]-(6-methoxypyridazin-3-yl)methanol, DNA (26-MER), DNA-dependent protein kinase catalytic subunit, ... | 著者 | Liang, S, Blundell, T.L. | 登録日 | 2022-03-16 | 公開日 | 2023-01-18 | 最終更新日 | 2023-03-01 | 実験手法 | ELECTRON MICROSCOPY (2.91 Å) | 主引用文献 | Human DNA-dependent protein kinase activation mechanism. Nat.Struct.Mol.Biol., 30, 2023
|
|
8ASC
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8asc by Molmil](/molmil-images/mine/8asc) | Ku70/80 binds to the Ku-binding motif of PAXX | 分子名称: | DNA (5'-D(P*CP*GP*GP*AP*TP*CP*GP*AP*GP*GP*GP*CP*CP*CP*GP*AP*TP*AP*T)-3'), DNA (5'-D(P*GP*GP*GP*CP*CP*CP*TP*CP*GP*AP*TP*CP*CP*G)-3'), Protein PAXX, ... | 著者 | Seif El Dahan, M, Ropars, V, Charbonnier, J.B. | 登録日 | 2022-08-19 | 公開日 | 2023-06-21 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | 主引用文献 | PAXX binding to the NHEJ machinery explains functional redundancy with XLF. Sci Adv, 9, 2023
|
|
7SGL
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7sgl by Molmil](/molmil-images/mine/7sgl) | DNA-PK complex of DNA end processing | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, DNA-dependent protein kinase catalytic subunit, Hairpin_1, ... | 著者 | Liu, L, Li, J, Chen, X, Yang, W, Gellert, M. | 登録日 | 2021-10-06 | 公開日 | 2022-01-12 | 最終更新日 | 2022-01-19 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Autophosphorylation transforms DNA-PK from protecting to processing DNA ends. Mol.Cell, 82, 2022
|
|
6ERF
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6erf by Molmil](/molmil-images/mine/6erf) | Complex of APLF factor and Ku heterodimer bound to DNA | 分子名称: | Aprataxin and PNK-like factor, DNA (34-MER), DNA (5'-D(*GP*TP*TP*TP*TP*TP*AP*GP*TP*TP*TP*AP*TP*TP*GP*GP*GP*CP*GP*CP*G)-3'), ... | 著者 | Nemoz, C, Legrand, P, Ropars, V, Charbonnier, J.B. | 登録日 | 2017-10-18 | 公開日 | 2018-10-17 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (3.01 Å) | 主引用文献 | XLF and APLF bind Ku80 at two remote sites to ensure DNA repair by non-homologous end joining. Nat.Struct.Mol.Biol., 25, 2018
|
|
7AXZ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7axz by Molmil](/molmil-images/mine/7axz) | Ku70/80 complex apo form | 分子名称: | X-ray repair cross-complementing protein 5, X-ray repair cross-complementing protein 6 | 著者 | Hnizda, A, Tesina, P, Novak, P, Blundell, T.L. | 登録日 | 2020-11-10 | 公開日 | 2021-02-10 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | SAP domain forms a flexible part of DNA aperture in Ku70/80. Febs J., 288, 2021
|
|
7SU3
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7su3 by Molmil](/molmil-images/mine/7su3) | CryoEM structure of DNA-PK complex VII | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, DNA (5'-D(*AP*AP*GP*CP*AP*GP*TP*AP*GP*AP*G)-3'), DNA (5'-D(*GP*CP*AP*TP*GP*CP*TP*CP*TP*AP*CP*TP*GP*CP*TP*TP*CP*GP*AP*TP*AP*TP*CP*G)-3'), ... | 著者 | Chen, X, Liu, L, Gellert, M, Yang, W. | 登録日 | 2021-11-16 | 公開日 | 2022-01-12 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Autophosphorylation transforms DNA-PK from protecting to processing DNA ends. Mol.Cell, 82, 2022
|
|
7Z88
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7z88 by Molmil](/molmil-images/mine/7z88) | DNA-PK in the intermediate state | 分子名称: | (~{S})-[2-chloranyl-4-fluoranyl-5-(7-morpholin-4-ylquinazolin-4-yl)phenyl]-(6-methoxypyridazin-3-yl)methanol, DNA (26-MER), DNA-dependent protein kinase catalytic subunit, ... | 著者 | Liang, S, Blundell, T.L. | 登録日 | 2022-03-16 | 公開日 | 2023-01-18 | 最終更新日 | 2023-03-01 | 実験手法 | ELECTRON MICROSCOPY (3.33 Å) | 主引用文献 | Human DNA-dependent protein kinase activation mechanism. Nat.Struct.Mol.Biol., 30, 2023
|
|
8AG5
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8ag5 by Molmil](/molmil-images/mine/8ag5) | Vaccinia C16 protein bound to Ku70/Ku80 | 分子名称: | Ku70-Xrcc6, Protein C10, X-ray repair cross-complementing protein 5 | 著者 | Rivera-Calzada, A, Arribas-Bosacoma, R, Pearl, L.H, Llorca, O. | 登録日 | 2022-07-19 | 公開日 | 2022-11-09 | 最終更新日 | 2022-11-30 | 実験手法 | ELECTRON MICROSCOPY (3.47 Å) | 主引用文献 | Structural basis for the inactivation of cytosolic DNA sensing by the vaccinia virus. Nat Commun, 13, 2022
|
|
7ZT6
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7zt6 by Molmil](/molmil-images/mine/7zt6) | |
7Z6O
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7z6o by Molmil](/molmil-images/mine/7z6o) | X-Ray studies of Ku70/80 reveal the binding site for IP6 | 分子名称: | DNA (5'-D(*GP*TP*TP*TP*TP*TP*AP*GP*TP*TP*TP*AP*T)-3'), DNA (5'-D(P*AP*AP*AP*TP*AP*AP*AP*CP*TP*AP*AP*AP*AP*AP*C)-3'), INOSITOL HEXAKISPHOSPHATE, ... | 著者 | Varela, P.F, Charbonnier, J.B. | 登録日 | 2022-03-14 | 公開日 | 2023-08-30 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (3.7 Å) | 主引用文献 | Structural and functional basis of inositol hexaphosphate stimulation of NHEJ through stabilization of Ku-XLF interaction. Nucleic Acids Res., 51, 2023
|
|
7K0Y
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7k0y by Molmil](/molmil-images/mine/7k0y) | Cryo-EM structure of activated-form DNA-PK (complex VI) | 分子名称: | DNA (5'-D(*AP*AP*GP*CP*AP*GP*TP*AP*GP*AP*GP*CP*A)-3'), DNA (5'-D(*GP*CP*AP*TP*GP*CP*TP*CP*TP*AP*CP*TP*GP*CP*TP*TP*CP*GP*AP*TP*AP*TP*CP*G)-3'), DNA-dependent protein kinase catalytic subunit, ... | 著者 | Chen, X, Gellert, M, Yang, W. | 登録日 | 2020-09-06 | 公開日 | 2021-01-06 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Structure of an activated DNA-PK and its implications for NHEJ. Mol.Cell, 81, 2021
|
|
7K1J
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7k1j by Molmil](/molmil-images/mine/7k1j) | CryoEM structure of inactivated-form DNA-PK (Complex III) | 分子名称: | DNA (5'-D(*AP*AP*GP*CP*AP*GP*TP*AP*GP*AP*GP*CP*A)-3'), DNA (5'-D(*GP*CP*AP*TP*GP*CP*TP*CP*TP*AP*CP*TP*GP*CP*TP*TP*CP*GP*AP*TP*AP*TP*CP*G)-3'), DNA-dependent protein kinase catalytic subunit, ... | 著者 | Chen, X, Gellert, M, Yang, W. | 登録日 | 2020-09-07 | 公開日 | 2021-01-06 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Structure of an activated DNA-PK and its implications for NHEJ. Mol.Cell, 81, 2021
|
|
7K1N
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7k1n by Molmil](/molmil-images/mine/7k1n) | CryoEM structure of inactivated-form DNA-PK (Complex V) | 分子名称: | DNA (5'-D(P*AP*AP*GP*CP*AP*GP*TP*AP*GP*AP*GP*CP*A)-3'), DNA (5'-D(P*GP*CP*AP*TP*GP*CP*TP*CP*TP*AP*CP*TP*GP*CP*TP*TP*CP*GP*AP*TP*AP*TP*CP*G)-3'), DNA-dependent protein kinase catalytic subunit, ... | 著者 | Chen, X, Gellert, M, Yang, W. | 登録日 | 2020-09-08 | 公開日 | 2021-01-06 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Structure of an activated DNA-PK and its implications for NHEJ. Mol.Cell, 81, 2021
|
|
6ZHA
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6zha by Molmil](/molmil-images/mine/6zha) | Cryo-EM structure of DNA-PK monomer | 分子名称: | DNA, DNA-dependent protein kinase catalytic subunit,DNA-dependent protein kinase catalytic subunit,DNA-dependent protein kinase catalytic subunit,DNA-PKcs, X-ray repair cross-complementing protein 5, ... | 著者 | Chaplin, A.K, Hardwick, S.W, Chirgadze, D.Y, Blundell, T.L. | 登録日 | 2020-06-21 | 公開日 | 2020-10-21 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (3.91 Å) | 主引用文献 | Dimers of DNA-PK create a stage for DNA double-strand break repair. Nat.Struct.Mol.Biol., 28, 2021
|
|
7K1K
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7k1k by Molmil](/molmil-images/mine/7k1k) | CryoEM structure of inactivated-form DNA-PK (Complex IV) | 分子名称: | DNA (5'-D(*AP*AP*GP*CP*AP*GP*TP*AP*GP*AP*GP*CP*A)-3'), DNA (5'-D(*GP*CP*AP*TP*GP*CP*TP*CP*TP*AP*CP*TP*GP*CP*TP*TP*CP*GP*AP*TP*AP*TP*CP*G)-3'), DNA-dependent protein kinase catalytic subunit, ... | 著者 | Chen, X, Gellert, M, Yang, W. | 登録日 | 2020-09-07 | 公開日 | 2021-01-06 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | 主引用文献 | Structure of an activated DNA-PK and its implications for NHEJ. Mol.Cell, 81, 2021
|
|
7NFC
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7nfc by Molmil](/molmil-images/mine/7nfc) | Cryo-EM structure of NHEJ super-complex (dimer) | 分子名称: | DNA (27-MER), DNA (28-MER), DNA ligase 4, ... | 著者 | Chaplin, A.K, Hardwick, S.W, Kefala Stavridi, A, Chirgadze, D.Y, Blundell, T.L. | 登録日 | 2021-02-05 | 公開日 | 2021-08-18 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (4.14 Å) | 主引用文献 | Cryo-EM of NHEJ supercomplexes provides insights into DNA repair. Mol.Cell, 81, 2021
|
|