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6ERF

Complex of APLF factor and Ku heterodimer bound to DNA

Summary for 6ERF
Entry DOI10.2210/pdb6erf/pdb
DescriptorX-ray repair cross-complementing protein 6, X-ray repair cross-complementing protein 5, DNA (5'-D(*GP*TP*TP*TP*TP*TP*AP*GP*TP*TP*TP*AP*TP*TP*GP*GP*GP*CP*GP*CP*G)-3'), ... (6 entities in total)
Functional Keywordsdna repair protein nhej, dna binding protein
Biological sourceHomo sapiens (Human)
More
Total number of polymer chains20
Total formula weight588176.31
Authors
Nemoz, C.,Legrand, P.,Ropars, V.,Charbonnier, J.B. (deposition date: 2017-10-18, release date: 2018-10-17, Last modification date: 2024-01-17)
Primary citationNemoz, C.,Ropars, V.,Frit, P.,Gontier, A.,Drevet, P.,Yu, J.,Guerois, R.,Pitois, A.,Comte, A.,Delteil, C.,Barboule, N.,Legrand, P.,Baconnais, S.,Yin, Y.,Tadi, S.,Barbet-Massin, E.,Berger, I.,Le Cam, E.,Modesti, M.,Rothenberg, E.,Calsou, P.,Charbonnier, J.B.
XLF and APLF bind Ku80 at two remote sites to ensure DNA repair by non-homologous end joining.
Nat.Struct.Mol.Biol., 25:971-980, 2018
Cited by
PubMed: 30291363
DOI: 10.1038/s41594-018-0133-6
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3.01 Å)
Structure validation

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