6ERF

Complex of APLF factor and Ku heterodimer bound to DNA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000723	biological_process	telomere maintenance
A	0003677	molecular_function	DNA binding
A	0003678	molecular_function	DNA helicase activity
A	0003684	molecular_function	damaged DNA binding
A	0005634	cellular_component	nucleus
A	0006303	biological_process	double-strand break repair via nonhomologous end joining
A	0042162	molecular_function	telomeric DNA binding
A	0043564	cellular_component	Ku70:Ku80 complex
B	0000723	biological_process	telomere maintenance
B	0003677	molecular_function	DNA binding
B	0003678	molecular_function	DNA helicase activity
B	0003684	molecular_function	damaged DNA binding
B	0005634	cellular_component	nucleus
B	0006303	biological_process	double-strand break repair via nonhomologous end joining
B	0006310	biological_process	DNA recombination
B	0042162	molecular_function	telomeric DNA binding
B	0043564	cellular_component	Ku70:Ku80 complex
C	0000723	biological_process	telomere maintenance
C	0003677	molecular_function	DNA binding
C	0003678	molecular_function	DNA helicase activity
C	0003684	molecular_function	damaged DNA binding
C	0005634	cellular_component	nucleus
C	0006303	biological_process	double-strand break repair via nonhomologous end joining
C	0042162	molecular_function	telomeric DNA binding
C	0043564	cellular_component	Ku70:Ku80 complex
D	0000723	biological_process	telomere maintenance
D	0003677	molecular_function	DNA binding
D	0003678	molecular_function	DNA helicase activity
D	0003684	molecular_function	damaged DNA binding
D	0005634	cellular_component	nucleus
D	0006303	biological_process	double-strand break repair via nonhomologous end joining
D	0006310	biological_process	DNA recombination
D	0042162	molecular_function	telomeric DNA binding
D	0043564	cellular_component	Ku70:Ku80 complex
E	0000723	biological_process	telomere maintenance
E	0003677	molecular_function	DNA binding
E	0003678	molecular_function	DNA helicase activity
E	0003684	molecular_function	damaged DNA binding
E	0005634	cellular_component	nucleus
E	0006303	biological_process	double-strand break repair via nonhomologous end joining
E	0042162	molecular_function	telomeric DNA binding
E	0043564	cellular_component	Ku70:Ku80 complex
F	0000723	biological_process	telomere maintenance
F	0003677	molecular_function	DNA binding
F	0003678	molecular_function	DNA helicase activity
F	0003684	molecular_function	damaged DNA binding
F	0005634	cellular_component	nucleus
F	0006303	biological_process	double-strand break repair via nonhomologous end joining
F	0006310	biological_process	DNA recombination
F	0042162	molecular_function	telomeric DNA binding
F	0043564	cellular_component	Ku70:Ku80 complex
G	0000723	biological_process	telomere maintenance
G	0003677	molecular_function	DNA binding
G	0003678	molecular_function	DNA helicase activity
G	0003684	molecular_function	damaged DNA binding
G	0005634	cellular_component	nucleus
G	0006303	biological_process	double-strand break repair via nonhomologous end joining
G	0042162	molecular_function	telomeric DNA binding
G	0043564	cellular_component	Ku70:Ku80 complex
H	0000723	biological_process	telomere maintenance
H	0003677	molecular_function	DNA binding
H	0003678	molecular_function	DNA helicase activity
H	0003684	molecular_function	damaged DNA binding
H	0005634	cellular_component	nucleus
H	0006303	biological_process	double-strand break repair via nonhomologous end joining
H	0006310	biological_process	DNA recombination
H	0042162	molecular_function	telomeric DNA binding
H	0043564	cellular_component	Ku70:Ku80 complex

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
B	LYS144
B	LYS265
B	LYS332
D	LYS144
D	LYS265
D	LYS332
F	LYS144
F	LYS265
F	LYS332
H	LYS144
H	LYS265
H	LYS332

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
B	SER255
B	SER258
B	SER318
D	SER255
D	SER258
D	SER318
F	SER255
F	SER258
F	SER318
H	SER255
H	SER258
H	SER318

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
B	THR535
D	THR535
F	THR535
H	THR535

---

site_id	SWS_FT_FI4
Number of Residues	16
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
A	LYS331
B	LYS532
B	LYS534
D	LYS195
C	LYS331
D	LYS532
D	LYS534
F	LYS195
E	LYS331
F	LYS532
F	LYS534
H	LYS195
H	LYS532
H	LYS534
B	LYS195
G	LYS331

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: Phosphoserine; by PRKDC => ECO:0000269|PubMed:9362500

Chain	Residue	Details
A	SER51
C	SER51
E	SER51
G	SER51

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163

Chain	Residue	Details
C	THR455
E	THR455
G	THR455
A	THR455

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER477
C	SER477
E	SER477
G	SER477

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER520
C	SER520
E	SER520
G	SER520

---

site_id	SWS_FT_FI9
Number of Residues	12
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
A	LYS287
A	LYS317
C	LYS287
C	LYS317
E	LYS287
E	LYS317
G	LYS287
G	LYS317

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