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PDB: 153 件
5UII
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BU of 5uii by Molmil
structure of DHFR with bound buformin and NADP
分子名称: CALCIUM ION, Dihydrofolate reductase, N-butyl-N'-(diaminomethylidene)guanidine, ...
著者Pedersen, L.C, London, R.E.
登録日2017-01-14
公開日2018-01-31
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.351 Å)
主引用文献A Structural Basis for Biguanide Activity.
Biochemistry, 56, 2017
4KJK
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BU of 4kjk by Molmil
Room Temperature WT DHFR
分子名称: CALCIUM ION, Dihydrofolate reductase, FOLIC ACID, ...
著者van den Bedem, H, Bhabha, G, Yang, K, Wright, P.E, Fraser, J.S.
登録日2013-05-03
公開日2013-08-21
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.351 Å)
主引用文献Automated identification of functional dynamic contact networks from X-ray crystallography.
Nat.Methods, 10, 2013
4KJL
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BU of 4kjl by Molmil
Room Temperature N23PPS148A DHFR
分子名称: Dihydrofolate reductase, FOLIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
著者van den Bedem, H, Bhabha, G, Yang, K, Wright, P.E, Fraser, J.S.
登録日2013-05-03
公開日2013-08-21
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.38 Å)
主引用文献Automated identification of functional dynamic contact networks from X-ray crystallography.
Nat.Methods, 10, 2013
5W3Q
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BU of 5w3q by Molmil
L28F E.coli DHFR in complex with NADPH
分子名称: CALCIUM ION, Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
著者Oyen, D, Wright, P.E, Wilson, I.A.
登録日2017-06-08
公開日2017-08-09
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.401 Å)
主引用文献Defining the Structural Basis for Allosteric Product Release from E. coli Dihydrofolate Reductase Using NMR Relaxation Dispersion.
J. Am. Chem. Soc., 139, 2017
5CCC
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BU of 5ccc by Molmil
wild-type E.coli dihydrofolate reductase complexed with 5,10-dideazatetrahydrofolate and oxidized nicotinamide adenine dinucleotide phosphate
分子名称: 5,10-DIDEAZATETRAHYDROFOLIC ACID, Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
著者Oyen, D, Wright, P.E.
登録日2015-07-01
公開日2015-08-05
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Cofactor-Mediated Conformational Dynamics Promote Product Release From Escherichia coli Dihydrofolate Reductase via an Allosteric Pathway.
J.Am.Chem.Soc., 137, 2015
3DAU
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BU of 3dau by Molmil
Crystal structure of the ternary MTX NADPH complex of Escherichia coli dihydrofolate reductase
分子名称: Dihydrofolate reductase, METHOTREXATE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
著者Bennett, B.C, Dealwis, C.G.
登録日2008-05-30
公開日2009-04-14
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献X-ray structure of the ternary MTX.NADPH complex of the anthrax dihydrofolate reductase: a pharmacophore for dual-site inhibitor design.
J.Struct.Biol., 166, 2009
1RA9
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BU of 1ra9 by Molmil
DIHYDROFOLATE REDUCTASE COMPLEXED WITH NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE (OXIDIZED FORM)
分子名称: DIHYDROFOLATE REDUCTASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
著者Sawaya, M.R, Kraut, J.
登録日1996-10-28
公開日1996-12-23
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Loop and subdomain movements in the mechanism of Escherichia coli dihydrofolate reductase: crystallographic evidence.
Biochemistry, 36, 1997
8UCX
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BU of 8ucx by Molmil
Dihydrofolate Reductase Complexed with Folate
分子名称: Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION
著者Fried, S.D.E, Boxer, S.G.
登録日2023-09-27
公開日2023-10-11
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.57 Å)
主引用文献Role of Electrostatics in Hydride Transfer by Dihydrofolate Reductase
To Be Published
7D4X
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BU of 7d4x by Molmil
X-ray crystal Structure of E.coli Dihydrofolate Reductase complexed with folate and NADP+ at pH7.0
分子名称: Dihydrofolate reductase, FOLIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
著者Wan, Q, Dealwis, C.
登録日2020-09-24
公開日2021-06-09
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.599 Å)
主引用文献Capturing the Catalytic Proton of Dihydrofolate Reductase: Implications for General Acid-Base Catalysis
Acs Catalysis, 11, 2021
4PDJ
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BU of 4pdj by Molmil
Neutron crystal Structure of E.coli Dihydrofolate Reductase complexed with folate and NADP+
分子名称: DIHYDROFOLIC ACID, Dihydrofolate reductase, MANGANESE (II) ION, ...
著者Wan, Q, Kovalevsky, A.Y, Wilson, M, Langan, P, Dealwis, C, Bennett, B.
登録日2014-04-18
公開日2015-04-15
最終更新日2024-04-03
実験手法NEUTRON DIFFRACTION (1.599 Å), X-RAY DIFFRACTION
主引用文献Toward resolving the catalytic mechanism of dihydrofolate reductase using neutron and ultrahigh-resolution X-ray crystallography.
Proc.Natl.Acad.Sci.USA, 111, 2014
1RA2
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BU of 1ra2 by Molmil
DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE AND NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE (OXIDIZED FORM)
分子名称: DIHYDROFOLATE REDUCTASE, FOLIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
著者Sawaya, M.R, Kraut, J.
登録日1996-10-28
公開日1996-12-23
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Loop and subdomain movements in the mechanism of Escherichia coli dihydrofolate reductase: crystallographic evidence.
Biochemistry, 36, 1997
6RUM
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BU of 6rum by Molmil
Crystal structure of GFP-LAMA-G97 - a GFP enhancer nanobody with cpDHFR insertion and TMP and NADPH
分子名称: CHLORIDE ION, DI(HYDROXYETHYL)ETHER, GFP-LAMA-G97 a GFP enhancer nanobody with cpDHFR insertion, ...
著者Farrants, H, Tarnawski, M, Mueller, T.G, Otsuka, S, Hiblot, J, Koch, B, Kueblbeck, M, Kraeusslich, H.-G, Ellenberg, J, Johnsson, K.
登録日2019-05-28
公開日2020-02-12
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Chemogenetic Control of Nanobodies.
Nat.Methods, 17, 2020
7D4L
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BU of 7d4l by Molmil
X-ray crystal Structure of E.coli Dihydrofolate Reductase complexed with folate and NADP+ at pH7.0
分子名称: Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ...
著者Wan, Q, Dealwis, C.
登録日2020-09-24
公開日2021-06-09
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Capturing the Catalytic Proton of Dihydrofolate Reductase: Implications for General Acid-Base Catalysis
Acs Catalysis, 11, 2021
4I13
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BU of 4i13 by Molmil
Nanobody ca1697 binding to the DHFR.folate binary complex
分子名称: Dihydrofolate reductase, FOLIC ACID, Protein ca1697 (nanobody)
著者Oyen, D, Steyaert, J, Barlow, J.N.
登録日2012-11-19
公開日2013-11-27
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Exploring an alternative antibody interaction mechanism
To be Published
5UIH
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BU of 5uih by Molmil
structure of DHFR with bound phenformin and NADP
分子名称: 1,2-ETHANEDIOL, BETA-MERCAPTOETHANOL, Dihydrofolate reductase, ...
著者Pedersen, L.C, London, R.E.
登録日2017-01-14
公開日2017-11-22
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.647 Å)
主引用文献A Structural Basis for Biguanide Activity.
Biochemistry, 56, 2017
7D3Z
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BU of 7d3z by Molmil
X-ray crystal Structure of E.coli Dihydrofolate Reductase complexed with folate and NADP+ at pH4.5
分子名称: Dihydrofolate reductase, FOLIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
著者Wan, Q, Dealwis, C.
登録日2020-09-21
公開日2021-06-09
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Capturing the Catalytic Proton of Dihydrofolate Reductase: Implications for General Acid-Base Catalysis
Acs Catalysis, 11, 2021
7D6G
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BU of 7d6g by Molmil
Neutron crystal Structure of E.coli Dihydrofolate Reductase complexed with folate and NADP+ at pH4.5
分子名称: Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ...
著者Wan, Q, Dealwis, C.
登録日2020-09-30
公開日2021-06-09
最終更新日2024-04-03
実験手法NEUTRON DIFFRACTION (1.65 Å), X-RAY DIFFRACTION
主引用文献Capturing the Catalytic Proton of Dihydrofolate Reductase: Implications for General Acid-Base Catalysis
Acs Catalysis, 11, 2021
7D49
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BU of 7d49 by Molmil
X-ray crystal Structure of E.coli Dihydrofolate Reductase complexed with folate and NADP+ at pH4.5
分子名称: Dihydrofolate reductase, FOLIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
著者Wan, Q, Dealwis, C.
登録日2020-09-23
公開日2021-06-09
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.651 Å)
主引用文献Capturing the Catalytic Proton of Dihydrofolate Reductase: Implications for General Acid-Base Catalysis
Acs Catalysis, 11, 2021
8G4Z
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BU of 8g4z by Molmil
E. coli DHFR complex with NADP+ and folate: EF-X off model by Laue diffraction (no electric field)
分子名称: Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ...
著者Greisman, J.B, Dalton, K.M, Brookner, D.E, Klureza, M.A, Hekstra, D.R.
登録日2023-02-10
公開日2024-01-03
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献E. coli DHFR complex with NADP+ and folate: EF-X off model by Laue diffraction (no electric field)
To Be Published
8G50
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BU of 8g50 by Molmil
E. coli DHFR complex with NADP+ and folate: EF-X excited state model by Laue diffraction (electric field along b axis; 8-fold extrapolation of structure factor differences)
分子名称: Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ...
著者Greisman, J.B, Dalton, K.M, Brookner, D.E, Klureza, M.A, Hekstra, D.R.
登録日2023-02-10
公開日2024-01-03
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献E. coli DHFR complex with NADP+ and folate: EF-X excited state model by Laue diffraction (electric field along b axis; 8-fold extrapolation of structure factor differences)
To Be Published
4DFR
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BU of 4dfr by Molmil
CRYSTAL STRUCTURES OF ESCHERICHIA COLI AND LACTOBACILLUS CASEI DIHYDROFOLATE REDUCTASE REFINED AT 1.7 ANGSTROMS RESOLUTION. I. GENERAL FEATURES AND BINDING OF METHOTREXATE
分子名称: CALCIUM ION, CHLORIDE ION, DIHYDROFOLATE REDUCTASE, ...
著者Filman, D.J, Matthews, D.A, Bolin, J.T, Kraut, J.
登録日1982-06-25
公開日1982-10-21
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Crystal structures of Escherichia coli and Lactobacillus casei dihydrofolate reductase refined at 1.7 A resolution. I. General features and binding of methotrexate.
J.Biol.Chem., 257, 1982
4X5F
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BU of 4x5f by Molmil
ecDHFR complexed with folate and NADP+ at 0.1 MPa
分子名称: BETA-MERCAPTOETHANOL, Dihydrofolate reductase, FOLIC ACID, ...
著者Yamada, H, Watanabe, N, Nagae, T.
登録日2014-12-05
公開日2016-01-13
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献High-pressure protein crystal structure analysis of Escherichia coli dihydrofolate reductase complexed with folate and NADP.
Acta Crystallogr D Struct Biol, 74, 2018
7LVC
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BU of 7lvc by Molmil
E. coli DHFR by Native Mn,P,S-SAD at Room Temperature
分子名称: Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ...
著者Greisman, J.B, Dalton, K.M, Hekstra, D.R.
登録日2021-02-24
公開日2021-03-17
最終更新日2022-08-17
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Native SAD phasing at room temperature.
Acta Crystallogr D Struct Biol, 78, 2022
5EAJ
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BU of 5eaj by Molmil
Crystal structure of DHFR in 0% Isopropanol
分子名称: CALCIUM ION, CHLORIDE ION, Dihydrofolate reductase, ...
著者Cuneo, M.J, Agarwal, P.K.
登録日2015-10-16
公開日2016-09-21
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.701 Å)
主引用文献Modulating Enzyme Activity by Altering Protein Dynamics with Solvent.
Biochemistry, 57, 2018
4EJ1
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BU of 4ej1 by Molmil
Binding of Nb113 camelid antibody fragment with the binary DHFR:folate complex
分子名称: Dihydrofolate reductase, FOLIC ACID, Nb113 camelid antibody fragment, ...
著者Oyen, D, Srinivasan, V.
登録日2012-04-06
公開日2013-04-24
最終更新日2013-10-30
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Mechanistic analysis of allosteric and non-allosteric effects arising from nanobody binding to two epitopes of the dihyrofolate reductase of Escherichia coli.
Biochim.Biophys.Acta, 1834, 2013

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件を2024-07-10に公開中

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