7D6G
Neutron crystal Structure of E.coli Dihydrofolate Reductase complexed with folate and NADP+ at pH4.5
Summary for 7D6G
Entry DOI | 10.2210/pdb7d6g/pdb |
Descriptor | Dihydrofolate reductase, MANGANESE (II) ION, FOLIC ACID, ... (5 entities in total) |
Functional Keywords | alpha beta alpha sandwich, oxidoreductase |
Biological source | Escherichia coli (strain K12) |
Total number of polymer chains | 1 |
Total formula weight | 19259.08 |
Authors | Wan, Q.,Dealwis, C. (deposition date: 2020-09-30, release date: 2021-06-09, Last modification date: 2024-04-03) |
Primary citation | Wan, Q.,Bennett, B.C.,Wymore, T.,Li, Z.,Wilson, M.A.,Brooks III, C.L.,Langan, P.,Kovalevsky, A.,Dealwis, C.G. Capturing the Catalytic Proton of Dihydrofolate Reductase: Implications for General Acid-Base Catalysis Acs Catalysis, 11:5873-5884, 2021 Cited by DOI: 10.1021/acscatal.1c00417PDB entries with the same primary citation |
Experimental method | NEUTRON DIFFRACTION (2.1 Å) X-RAY DIFFRACTION (1.65 Å) |
Structure validation
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