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7D6G

Neutron crystal Structure of E.coli Dihydrofolate Reductase complexed with folate and NADP+ at pH4.5

Summary for 7D6G
Entry DOI10.2210/pdb7d6g/pdb
DescriptorDihydrofolate reductase, MANGANESE (II) ION, FOLIC ACID, ... (5 entities in total)
Functional Keywordsalpha beta alpha sandwich, oxidoreductase
Biological sourceEscherichia coli (strain K12)
Total number of polymer chains1
Total formula weight19259.08
Authors
Wan, Q.,Dealwis, C. (deposition date: 2020-09-30, release date: 2021-06-09, Last modification date: 2024-04-03)
Primary citationWan, Q.,Bennett, B.C.,Wymore, T.,Li, Z.,Wilson, M.A.,Brooks III, C.L.,Langan, P.,Kovalevsky, A.,Dealwis, C.G.
Capturing the Catalytic Proton of Dihydrofolate Reductase: Implications for General Acid-Base Catalysis
Acs Catalysis, 11:5873-5884, 2021
Cited by
DOI: 10.1021/acscatal.1c00417
PDB entries with the same primary citation
Experimental method
NEUTRON DIFFRACTION (2.1 Å)
X-RAY DIFFRACTION (1.65 Å)
Structure validation

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